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    Interventional procedure overview of Balloon cryoablation for treating Barrett's oesophagus

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    Outcome measures

    Safety and efficacy outcomes are included. Further details are provided below.

    Patient safety

    Identified outcomes relevant to safety include:

    • Pain/discomfort

      • Measured using either a 10-point Likert or visual analogue scale (VAS), with 0 indicating no pain and 10 indicating worst pain

    • Adverse events (AE)

      • Bleeding

      • Oesophageal perforation

      • Oesophageal stricture

    • Dysphagia

    • Device malfunction

    Efficacy

    Identified outcomes relevant to BE include:

    • Complete eradication or remission of dysplasia

    • Complete eradication of internal metaplasia

    • BE surface regression

      • Proportion of BE converted to squamous epithelium, measured by independent expert assessors comparing pre- and post-CBA images or videos

    • Disease progression

      • Progression to more advanced dysplasia or ImCA

    • Conversion to neo-squamous epithelium

    • Technical success

      • Treatment of all visible BE as intended

    • Treatment failure

      • Residual requiring further treatment (CBA or otherwise)

    Prague classification

    The Prague classification for BE is reported across some studies. This is a standardised system used during endoscopy to measure and describe the extent of BE. The classification includes both the maximal length (M) (including tongues) of BE, and the length of the circumferential Barrett segment (C).