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  • Question on Consultation

    Are the summaries of clinical and cost effectiveness reasonable interpretations of the evidence?

  • Question on Consultation

    Are the recommendations sound and a suitable basis for guidance to the NHS?

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    Are there any aspects of the recommendations that need particular consideration to ensure we avoid unlawful discrimination against any group of people on the grounds of race, gender, disability, religion or belief, sexual orientation, age, gender reassignment, pregnancy and maternity?

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    Has all of the relevant evidence been taken into account?
The content on this page is not current guidance and is only for the purposes of the consultation process.

1 Recommendations

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2 Information about daratumumab

Marketing authorisation indication

2.1

Daratumumab (Darzalex, Johnson & Johnson) is indicated 'in combination with bortezomib, lenalidomide and dexamethasone for the treatment of adult patients with newly diagnosed multiple myeloma'.

Price

2.3

The list price for daratumumab is £4,320 per 1,800 mg/15 ml vial (excluding VAT; BNF online accessed December 2025).

2.4

The company has a commercial arrangement. This makes daratumumab available to the NHS with a discount and it would have also applied to this indication if daratumumab with bortezomib, lenalidomide and dexamethasone had been recommended. The size of the discount is commercial in confidence.

Carbon Reduction Plan

2.5

Information on the Carbon Reduction Plan for UK carbon emissions for Johnson & Johnson will be included here when guidance is published.