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    Has all of the relevant evidence been taken into account?

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    Are the summaries of clinical and cost effectiveness reasonable interpretations of the evidence?

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    Are the recommendations sound and a suitable basis for guidance to the NHS?

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    Are there any aspects of the recommendations that need particular consideration to ensure we avoid unlawful discrimination against any group of people on the grounds of age, disability, gender reassignment, pregnancy and maternity, race, religion or belief, sex or sexual orientation?

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2 Information about Upadacitinib

Marketing authorisation indication

2.1

Upadacitinib (RINVOQ, AbbVie) is indicated for 'the treatment of giant cell arteritis in adult patients'.

Dosage in the marketing authorisation

2.2

The dosage schedule is available in the

2.3

The list price for upadacitinib is £805.56 for a pack of 28 x 15 mg tablets (excluding VAT; BNF online, accessed December 2025).

2.4

The company has a commercial arrangement. This makes upadacitinib available to the NHS with a discount and it would have also applied to this indication if upadacitinib had been recommended. The size of the discount is commercial in confidence.

Carbon Reduction Plan

2.5

Information on the Carbon Reduction Plan for UK carbon emissions for AbbVie will be included here when guidance is published.