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  • Question on Consultation

    Is the proposed process for updating TA924 appropriate to achieve useful and usable guidance?

  • Question on Consultation

    Is the proposed process sufficiently clear? Are further details of the proposed process required by stakeholders?

  • Question on Consultation

    Should NICE consider adapting other elements of the proposed process to achieve more useful and usable guidance?

  • Question on Consultation

    Do you have any other comments on the proposed process for updating TA924 within the proportionate decision-making process?

  • Question on Consultation

    Would it be challenging to implement of any of the recommendations for the updated TA? Please say why and for whom, and how these could be mitigated.

  • Question on Consultation

    Would implementation of any of the recommendations have significant cost implications?

Review proposal of TA924

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Rationale for change

  1. The NICE Centre for Guidelines is currently conducting a partial update of NICE guideline 28 (NG28) Type 2 diabetes in adults: management. NICE is updating our recommendations on drug therapy. The update will be published on 18 February 2026.

  2. The recommendations in the update to NG28 are inconsistent with the technology appraisals which cover the management of type 2 diabetes. This inconsistency needs to be resolved so that NICE can produce useful and usable recommendations.

  3. The changes to the evidence base and clinical pathway for drug therapies for treating type 2 diabetes in adults also impact the recommendations for canagliflozin, dapagliflozin, empagliflozin and ertugliflozin for treating type 2 diabetes. These are covered in TA288, TA315, TA336, TA390, TA418, TA572, TA583. The updates to these TAs are covered by a separate review proposal paper.