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Acalabrutinib with bendamustine and rituximab for untreated mantle cell lymphoma

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2 Information about acalabrutinib with bendamustine and rituximab

Marketing authorisation indication

2.1

Acalabrutinib (Calquence, AstraZeneca) plus bendamustine and rituximab is indicated for 'the treatment of adult patients with previously untreated mantle cell lymphoma (MCL) who are not eligible for autologous stem cell transplant (ASCT)'.

Dosage in the marketing authorisation

Price

2.3

The list price of acalabrutinib is £5,059.00 per 60-pack of 100‑mg tablets (excluding VAT, BNF online, accessed February 2026).

2.4

The company has a commercial arrangement. This makes acalabrutinib available to the NHS with a discount and it would have also applied to this indication if acalabrutinib plus bendamustine and rituximab had been recommended. The size of the discount is commercial in confidence.

Sustainability

2.5

Information on the Carbon Reduction Plan for UK carbon emissions for AstraZeneca will be included here when guidance is published.