How are you taking part in this consultation?

You will not be able to change how you comment later.

You must be signed in to answer questions

  • Question on Consultation

    Has all of the relevant evidence been taken into account?

  • Question on Consultation

    Are the summaries of clinical and cost effectiveness reasonable interpretations of the evidence?

  • Question on Consultation

    Are the recommendations sound and a suitable basis for guidance to the NHS?

  • Question on Consultation

    Are there any aspects of the recommendations that need particular consideration to ensure we avoid unlawful discrimination against any group of people on the grounds of age, disability, gender reassignment, pregnancy and maternity, race, religion or belief, sex or sexual orientation?

1 Recommendations

Open for comments Open until   Request commenting lead permission

We have updated this service so that members of the same organisation can now collaborate on a joint online response.

Read our blog to learn more.

2 Information about nirogacestat

Marketing authorisation indication

2.1

Nirogacestat (Ogsiveo, SpringWorks Therapeutics) is indicated for 'the treatment of adult patients with progressing DT who require systemic treatment'.

Dosage in the marketing authorisation

Price

2.3

The anticipated list price is £15,189.04 per 56 pack of 150‑mg tablets (company submission).

2.4

The company has a commercial arrangement, which would have applied if nirogacestat had been recommended.

Sustainability

2.5

Information on the Carbon Reduction Plan for UK carbon emissions for SpringWorks Therapeutics will be included here when guidance is published.