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  • Question on Consultation

    Has all of the relevant evidence been taken into account?

  • Question on Consultation

    Are the summaries of clinical and cost effectiveness reasonable interpretations of the evidence?

  • Question on Consultation

    Are the recommendations sound and a suitable basis for guidance to the NHS?

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    Are there any aspects of the recommendations that need particular consideration to ensure we avoid unlawful discrimination against any group of people on the grounds of age, disability, gender reassignment, pregnancy and maternity, race, religion or belief, sex or sexual orientation?
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1 Recommendations

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2 Information about nirogacestat

Marketing authorisation indication

2.1

Nirogacestat (Ogsiveo, SpringWorks Therapeutics) is indicated for 'the treatment of adult patients with progressing DT who require systemic treatment'.

Price

2.3

The anticipated list price is £15,189.04 per 56 pack of 150‑mg tablets (company submission).

2.4

The company has a commercial arrangement, which would have applied if nirogacestat had been recommended.

Sustainability

2.5

Information on the Carbon Reduction Plan for UK carbon emissions for SpringWorks Therapeutics will be included here when guidance is published.