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Sodium zirconium cyclosilicate for treating hyperkalaemia

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2 Information about sodium zirconium cyclosilicate

Marketing authorisation indication

Sodium zirconium cyclosilicate (Lokelma, AstraZeneca) has a marketing authorisation 'for the treatment of hyperkalaemia in adult patients'.

Dosage in the marketing authorisation

Correction phase:

The recommended starting does of sodium zirconium cyclosilicate is 10 g, administered 3 times a day orally as a suspension in water. When normal serum potassium levels are met, the maintenance regimen should be followed. If normal serum potassium levels are not met within 72 hours of treatment, sodium zirconium cyclosilicate should be stopped

Maintenance phase:

For people with normal serum potassium levels after the correction phase, the minimal effective dose of sodium zirconium cyclosilicate to prevent recurrence of hyperkalaemia should be established. A starting dose of 5 g once daily is recommended, with possible titration up to a maximum 10 g once daily or down to 5 g once every other day as needed to maintain a normal serum potassium level.

Price

The list price of sodium zirconium cyclosilicate is £14.24 per 10 g sachet or £7.12 per 5 g sachet (DHSC eXchange, maximum list prices, accessed April 2019). Costs may vary in different settings because of negotiated procurement discounts.