Studies identified in searches are summarised from the information presented in their abstracts. We did not specify any age limits on HRT treatment because this information was not consistently reported clearly across the abstracts.

Because of a large volume of evidence, we excluded randomised controlled trials that included less than 100 people.

Feedback from topic experts who advised us on the approach to this surveillance review, was considered alongside the evidence to reach a view on the need to update each section of the guideline.

See the evidence tables for all studies considered in surveillance.