The NICE glossary provides brief definitions and explanations of terms used on the website. The terms describe how NICE works and how its guidance is produced.
Our glossary excludes specific clinical and medical terms. If you cannot find the term you are looking for, please email us so that we can consider adding it to the glossary.
Some definitions and examples are based on those in the HTAi consumer and patient glossary, with thanks to Health Technology Assessment International.
For terms used in social care, the Care and Support Jargon Buster from Think Local Act Personal is a useful guide to the most commonly used social care words and phrases, and what they mean.
The likelihood of an event or outcome occurring (for example, an adverse reaction to the drug being tested) among the group being studied. Studies that compare 2 or more groups of people may report results in terms of the absolute risk reduction.
An increase in the likelihood of an event or outcome occurring as a result of a treatment or another intervention, sometimes called the risk difference. It is broadly the same as the absolute risk reduction but occurs in the opposite direction. For example, if a treatment increased the absolute risk of major haemorrhage from 0.10 (10%) to 0.25 (25%) the ARI is 0.15 (15%), that is, 0.25 minus 0.10 (25% minus 10%). The absolute risk increase is related to the number needed to harm (NNH).
A reduction in the likelihood of an event or outcome occurring as a result of a treatment or another intervention, sometimes called the risk difference. For example, if a treatment reduces the absolute risk of death from 0.25 (25%) to 0.10 (10%), the ARR is 0.15 (15%), that is, 0.25 minus 0.10 (25% minus 10%). The estimate of absolute risk reduction often comes from clinical trials. The percentage of people taking part who are having treatment (treatment group) and experience a specific outcome is compared with the percentage of people taking part but not having treatment (control group) who experience the same outcome. The absolute risk reduction is related to the number needed to treat (NNT).
A summary of a study, which may be published alone or as an introduction to a full scientific paper.
An unintended effect that is harmful or otherwise unwanted, and suspected to be related to, or caused by, a drug, treatment or intervention. See also Side effect.
Any undesirable event experienced by a person while they are having a drug or any other treatment or intervention, regardless of whether or not the event is suspected to be related to or caused by the drug, treatment or intervention.
An unintended reaction that is harmful or otherwise unwanted which is experienced by a person after having a drug or any other treatment or intervention, and which is suspected to be related to, or caused by the drug, treatment or intervention.
The process used to prevent (conceal) advanced knowledge of what intervention group people have been assigned to in a randomised controlled trial. It should be done by someone who is not responsible for recruiting people into the trial. The process prevents researchers from (unconsciously or otherwise) influencing which people are assigned to a given intervention group. Allocation concealment is different from blinding or masking; a double blind study can have unconcealed allocation and an open-label (unblinded) study can have concealed allocation.
The process of looking for patterns in information to identify cause and effect or answer specific questions, such as whether a treatment or other intervention works and what the risks are.
There are 2 types of analysis. Quantitative analysis looks for patterns in the form of numbers, such as most frequent choice of treatment option or average rating of pain during treatment. Qualitative analysis looks for patterns of meaning, feeling or beliefs. It can lead to a finding such as 'most people who support paying more for end-of-life therapy also believe society should give more to those with greater need'.
The final part of the process for producing technology appraisal and highly specialised technology guidance. Organisations representing patients and carers, healthcare professionals and companies can appeal against final advice given by the independent appraisal committee on a specific medicine or treatment. The grounds for appeal are that NICE has failed to act fairly, or has exceeded its powers, or that a recommendation is unreasonable in light of the evidence submitted.
How well an observation or the results of a study or review are likely to hold true in a particular setting.
An independent committee that develops NICE's guidance on using drugs or treatments in the NHS (called technology appraisal guidance). It is made up of healthcare professionals and NHS managers, researchers, lay representatives, and people who work for drug companies and medical equipment manufacturers.
The appraisal committee's draft guidance on using a drug (or group of drugs) or treatment in the NHS (called technology appraisal guidance). The companies and organisations who have been invited as consultees and commentators can comment on this draft guidance.
Subsection of people within a study who have a particular intervention (for example, the 'usual care' arm).
An independent group of researchers commissioned by NICE to review the evidence on a group of treatments, for a multiple technology appraisal. The assessment group includes researchers who assess the quality of studies on the treatments, and health economists who look at whether the treatments are good value for money. The appraisal committee bases its discussions on the assessment report produced by the assessment group.
A review of the evidence about how well health technologies work and how much value for money they present. The assessment report forms the basis of the Appraisal Committee's discussions. The assessment report is written by an Assessment Group. Assessment reports are produced for treatments being assessed using the multiple technology appraisal process.
A systematic review of a practice, process or performance to establish how well it meets predetermined criteria. The procedure includes identifying problems, developing solutions, making changes to practice, and then reviewing the whole operation or service again. For example, an audit may be carried out on a specific service (such as 'stop smoking' services), to check whether it complies with laws, regulations or policies. See also Clinical audit.
A subcommittee of NICE's board that keeps a check on NICE's finances and other aspects of the way the organisation is run.
Records of action to assess practice against standards. Also, a clear record of actions so that the reasons for the actions are apparent to a third party. For example, the reasons for changes to a draft guideline should be clearly recorded.