April 2017: Recommendation 126.96.36.199 was updated in line with more recent guidance on recognition and referral for suspected cancer. This recommendation is dated . Recommendation 188.8.131.52 was removed as it was no longer needed after the changes to recommendation 184.108.40.206.
February 2015: New recommendations on dietary and lifestyle advice and pharmacological therapy were added to the clinical management of IBS section.
Recommendations are marked as , [new 2015],  and :
Please note that in the 2015 update, recommendation 220.127.116.11 was added. Therefore, the recommendations that were numbered as 18.104.22.168 to 22.214.171.124 in the 2008 guideline have been renumbered as recommendations 126.96.36.199 to 188.8.131.52 in the 2015 update. The 2008 recommendation numbers have been retained in the full guideline.
Some recommendations can be made with more certainty than others. The Committee makes a recommendation based on the trade‑off between the benefits and harms of an intervention, taking into account the quality of the underpinning evidence. For some interventions, the Committee is confident that, given the information it has looked at, most patients would choose the intervention. The wording used in the recommendations in this guideline denotes the certainty with which the recommendation is made (the strength of the recommendation).
For all recommendations, NICE expects that there is discussion with the patient about the risks and benefits of the interventions, and their values and preferences. This discussion aims to help them to reach a fully informed decision (see also patient-centred care).
We usually use 'must' or 'must not' only if there is a legal duty to apply the recommendation. Occasionally we use 'must' (or 'must not') if the consequences of not following the recommendation could be extremely serious or potentially life threatening.
We use 'offer' (and similar words such as 'refer' or 'advise') when we are confident that, for the vast majority of patients, an intervention will do more good than harm, and be cost effective. We use similar forms of words (for example, 'Do not offer…') when we are confident that an intervention will not be of benefit for most patients.
We use 'consider' when we are confident that an intervention will do more good than harm for most patients, and be cost effective, but other options may be similarly cost effective. The choice of intervention, and whether or not to have the intervention at all, is more likely to depend on the patient's values and preferences than for a strong recommendation, and so the healthcare professional should spend more time considering and discussing the options with the patient.
NICE began using this approach to denote the strength of recommendations in guidelines that started development after publication of the 2009 version of 'The guidelines manual' (January 2009). This does not apply to any recommendations ending  (see 'Update information' above for details about how recommendations are labelled). In particular, for recommendations labelled  the word 'consider' may not necessarily be used to denote the strength of the recommendation.