Key priorities for implementation

Key priorities for implementation

The following recommendations were identified as priorities for implementation in the 2008 guideline and have not been changed in the 2015 update.

Initial assessment

  • Healthcare professionals should consider assessment for IBS if the person reports having had any of the following symptoms for at least 6 months:

    • Abdominal pain or discomfort

    • Bloating

    • Change in bowel habit. [2008]

  • A diagnosis of IBS should be considered only if the person has abdominal pain or discomfort that is either relieved by defaecation or associated with altered bowel frequency or stool form. This should be accompanied by at least two of the following four symptoms:

    • altered stool passage (straining, urgency, incomplete evacuation)

    • abdominal bloating (more common in women than men), distension, tension or hardness

    • symptoms made worse by eating

    • passage of mucus.

      Other features such as lethargy, nausea, backache and bladder symptoms are common in people with IBS, and may be used to support the diagnosis. [2008]

Diagnostic tests

  • In people who meet the IBS diagnostic criteria, the following tests should be undertaken to exclude other diagnoses:

    • full blood count (FBC)

    • erythrocyte sedimentation rate (ESR) or plasma viscosity

    • c‑reactive protein (CRP)

    • antibody testing for coeliac disease (endomysial antibodies [EMA] or tissue transglutaminase [TTG]). [2008]

  • The following tests are not necessary to confirm diagnosis in people who meet the IBS diagnostic criteria:

    • ultrasound

    • rigid/flexible sigmoidoscopy

    • colonoscopy; barium enema

    • thyroid function test

    • faecal ova and parasite test

    • faecal occult blood

    • hydrogen breath test (for lactose intolerance and bacterial overgrowth). [2008]

Dietary and lifestyle advice

  • People with IBS should be given information that explains the importance of self‑help in effectively managing their IBS. This should include information on general lifestyle, physical activity, diet and symptom‑targeted medication. [2008]

  • Healthcare professionals should review the fibre intake of people with IBS, adjusting (usually reducing) it while monitoring the effect on symptoms. People with IBS should be discouraged from eating insoluble fibre (for example, bran). If an increase in dietary fibre is advised, it should be soluble fibre such as ispaghula powder or foods high in soluble fibre (for example, oats). [2008]

Pharmacological therapy

  • People with IBS should be advised how to adjust their doses of laxative or antimotility agent according to the clinical response. The dose should be titrated according to stool consistency, with the aim of achieving a soft, well‑formed stool (corresponding to Bristol Stool Form Scale type 4). [2008]

  • Consider tricyclic antidepressants (TCAs) as second‑line treatment for people with IBS if laxatives, loperamide or antispasmodics have not helped. Start treatment at a low dose (5–10 mg equivalent of amitriptyline), taken once at night, and review regularly. Increase the dose if needed, but not usually beyond 30 mg.[1][2015]



[1] At the time of publication (February 2015), TCAs did not have a UK marketing authorisation for this indication. The prescriber should follow relevant professional guidance, taking full responsibility for the decision. Informed consent should be obtained and documented. See the General Medical Council's Good practice in prescribing and managing medicines and devices for further information.

  • National Institute for Health and Care Excellence (NICE)