Atezolizumab for untreated advanced or recurrent non-small-cell lung cancer when platinum-doublet chemotherapy is unsuitable (terminated appraisal) (TA1047)Product type:GuidanceProgramme:Technology appraisal guidancePublished: 12 March 2025
Osimertinib for adjuvant treatment of EGFR mutation-positive non-small-cell lung cancer after complete tumour resection (TA1043)Product type:GuidanceProgramme:Technology appraisal guidancePublished: 26 February 2025
Durvalumab with etoposide and either carboplatin or cisplatin for untreated extensive-stage small-cell lung cancer (TA1041)Product type:GuidanceProgramme:Technology appraisal guidancePublished: 19 February 2025
Selpercatinib for previously treated RET fusion-positive advanced non-small-cell lung cancer (TA1042)Product type:GuidanceProgramme:Technology appraisal guidancePublished: 19 February 2025
Pembrolizumab for adjuvant treatment of resected non-small-cell lung cancer (TA1037)Product type:GuidanceProgramme:Technology appraisal guidancePublished: 5 February 2025
Durvalumab with chemotherapy before surgery (neoadjuvant) then alone after surgery (adjuvant) for treating resectable non-small-cell lung cancer (TA1030)Product type:GuidanceProgramme:Technology appraisal guidancePublished: 15 January 2025
Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer (TA1021)Product type:GuidanceProgramme:Technology appraisal guidancePublished: 4 December 2024
Pembrolizumab with chemotherapy before surgery (neoadjuvant) then alone after surgery (adjuvant) for treating resectable non-small-cell lung cancer (TA1017)Product type:GuidanceProgramme:Technology appraisal guidancePublished: 20 November 2024
Alectinib for adjuvant treatment of ALK-positive non-small-cell lung cancer (TA1014)Product type:GuidanceProgramme:Technology appraisal guidancePublished: 13 November 2024
Amivantamab with carboplatin and pemetrexed for untreated EGFR exon 20 insertion mutation-positive advanced non-small-cell lung cancer [ID5110]Status:In development | In consultationProgramme:Technology appraisal guidanceConsultation end date: 27 March 2025Expected publication date: 30 April 2025
Adagrasib for previously treated KRAS G12C mutation-positive advanced non-small-cell lung cancer [ID6339]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: 2 July 2025
Encorafenib with binimetinib for treating BRAF V600E mutation-positive advanced non-small-cell lung cancer [ID6177]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: 23 July 2025
Atezolizumab for adjuvant treatment of resected non-small-cell lung cancer (MA review of TA823) [ID6324]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: 23 July 2025
Lorlatinib for untreated ALK-positive advanced non-small-cell lung cancer (Review of TA909) [ID6434]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: 24 July 2025
Tarlatamab for previously treated advanced small-cell lung cancer [ID6364]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: 6 August 2025
Datopotamab deruxtecan for treating advanced non-small-cell lung cancer after platinum-based chemotherapy [ID6241]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: 13 August 2025
Durvalumab for treating limited-stage small-cell lung cancer after chemoradiation [ID5073]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: 20 August 2025
Osimertinib for maintenance treatment of EGFR mutation-positive locally advanced unresectable non-small-cell lung cancer after platinum-based chemoradiation [ID6223]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: 20 August 2025
Amivantamab with lazertinib for untreated EGFR mutation-positive advanced non-small-cell lung cancer [ID6256]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: 20 August 2025
Serplulimab with carboplatin and etoposide for untreated extensive-stage small-cell lung cancer [ID6346]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: 18 September 2025
Nivolumab as neoadjuvant (with chemotherapy) and adjuvant (as monotherapy) treatment for resectable non-small-cell lung cancer [ID6310]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: 24 September 2025
Atezolizumab as neoadjuvant (with chemotherapy) and adjuvant (as monotherapy) treatment for resectable non-small-cell lung cancer [ID3894]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Aumolertinib for untreated EGFR mutation-positive non-small-cell lung cancer [ID4000]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Cemiplimab with platinum-based chemotherapy for untreated advanced non-small-cell lung cancer [ID3949]Status:In development | In consultationProgramme:Technology appraisal guidanceConsultation end date: 26 March 2025Expected publication date: TBC
Durvalumab with tremelimumab for treating limited-stage small-cell lung cancer after chemoradiation [ID5097]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Pembrolizumab with stereotactic body radiotherapy for treating unresected stage 1 or 2 non-small-cell lung cancer [ID6149]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Tislelizumab for treating advanced non-small-cell lung cancer after platinum-based chemotherapy ID6161Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Tislelizumab in combination for untreated advanced non-small-cell lung cancer ID6162Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Durvalumab with tremelimumab for treating limited-stage small-cell lung cancer after chemoradiation [ID5097]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Lazertinib with amivantamab and platinum-based chemotherapy for EGFR mutation-positive metastatic non-small-cell lung cancer after a tyrosine kinase inhibitor [TSID11822]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Osimertinib with pemetrexed and platinum-based chemotherapy for untreated EGFR mutation-positive advanced non-small-cell lung cancer [ID6328]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Pembrolizumab–vibostolimab for untreated metastatic non-small-cell lung cancer [ID6365]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Vibostolimab–pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer [ID6382]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Tiragolumab in combination for untreated advanced non-squamous non-small-cell lung cancer [ID6443]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Sotorasib for previously treated KRAS G12C mutation-positive advanced non-small-cell lung cancer (MA review of TA781) [ID6287]Status:In developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Pembrolizumab with olaparib and chemoradiation for previously untreated limited-stage small-cell lung cancer [ID6412]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Pembrolizumab with chemoradiation, then with or without olaparib, for untreated unresectable locally advanced non-small-cell lung cancer [ID6399]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Lurbinectedin with atezolizumab for maintenance treatment of extensive-stage small-cell lung cancer PD [ID6526]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Retifanlimab with chemotherapy for previously untreated metastatic non-small-cell lung cancer [ID6436]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Subcutaneous amivantamab for treating advanced non-small-cell lung cancer with EGFR mutations [TSID12011]Status:Topic selectionProgramme:Technology appraisal guidanceExpected publication date: TBC
Patritumab deruxtecan for treating EGFR mutation-positive advanced non-small-cell lung cancer after 1 or 2 tyrosine kinase inhibitor treatment [ID6467]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Osimertinib for neoadjuvant treatment of EGFR mutation-positive resectable non-small-cell lung cancer [ID6472]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Tiragolumab–atezolizumab for PD-L1-positive recurrent or advanced non-small-cell lung cancer untreated with checkpoint inhibitors [TSID12064]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Savolitinib with osimertinib for treating EGFR-mutated MET-overexpressed or amplified advanced non-small-cell lung cancer after osimertinib [ID6494]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Dostarlimab and docetaxel for treating advanced non-small-cell lung cancer after anti-PD-L1 treatment and chemotherapy [TSID12115]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Entrectinib for treating NTRK fusion-positive solid tumours in people 1 month to 11 years [TSID12116]Status:Topic selectionProgramme:Technology appraisal guidanceExpected publication date: TBC
Datopotamab deruxtecan with durvalumab and carboplatin for untreated TROP2-positive advanced non-small-cell lung cancer without actionable genomic alterations [ID6522]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Repotrectinib for treating NTRK fusion-positive advanced solid tumours in people 12 years and over [TSID12147]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC
Trastuzumab deruxtecan for untreated HER2-mutated unresectable advanced non-small-cell lung cancer [TSID12104]Status:Awaiting developmentProgramme:Technology appraisal guidanceExpected publication date: TBC