Suggested remit: To appraise the clinical and cost effectiveness of cemiplimab with chemotherapy within its marketing authorisation for untreated advanced or metastatic NSCLC.
 
Status In progress
Technology type Medicine
Decision Selected
Process STA Standard
ID number 3949

Provisional Schedule

Expected publication 30 April 2025

Project Team

Project lead Celia Mayers

Email enquiries

Stakeholders

Companies sponsors Regeneron (cemiplimab)
Others Department of Health and Social Care
  NHS England
Patient carer groups Asthma and Lung UK
  Black Health Agency for Equality
  Cancer Black Care
  Cancer Equality
  Helen Rollason Cancer Charity
  Independent Cancer Patients Voice
  Macmillan Cancer Support
  Maggie’s Centres
  Marie Curie
  Oncogene - Driven Lung Cancer Patient Alliance UK.
  Roy Castle Lung Cancer Foundation
  South Asian Health Foundation
  Specialised Healthcare Alliance
  Tenovus Cancer Care
  UK Lung Cancer Coalition
Professional groups Association of Anaesthetists
  Association of Cancer Physicians
  Association of Respiratory Nurse Specialists
  Association of Surgeons of Great Britain and Ireland
  British Geriatrics Society
  British Institute of Radiology
  British Oncology Pharmacy Association
  British Psychosocial Oncology Society
  British Society of Interventional Radiology
  British Thoracic Oncology Group
  British Thoracic Society
  British Transplantation Society
  Cancer Research UK
  Lung Cancer and Mesothelioma Clinical Expert Group
  Lung Cancer Nursing UK
  National Heart and Lung Institute
  NHS Blood and Transplant
  Primary Care Respiratory Society
  Royal College of Anaesthetists
  Royal College of General Practitioners
  Royal College of Nursing
  Royal College of Pathologists
  Royal College of Physicians
  Royal College of Radiologists
  Royal College of Surgeons
  Royal Pharmaceutical Society
  Royal Society of Medicine
  Society and College of Radiographers
  UK Clinical Pharmacy Association
  UK Oncology Nursing Society
Assessment group Public Health Wales
  UK Health Security Agency
Comparator companies Bristol Myers Squibb (paclitaxel)
  Eli Lilly (pemetrexed)
  Hospira UK (carboplatin, paclitaxel)
  Medac (vinorelbine)
  MSD (pembrolizumab)
  Pierre Fabre (vinorelbine)
  Pfizer (pemetrexed, cisplatin, carboplatin, gemcitabine)
  Ranbaxy (gemcitabine, pemetrexed)
  Roche (atezolizumab, bevacizumab)
  Seacross Pharmaceuticals (paclitaxel)
  Sandoz (cisplatin)
  Synchrony Pharma (gemcitabine)
  Teva UK (paclitaxel)
General commentators All Wales Therapeutics and Toxicology Centre
  Allied Health Professionals Federation
  Board of Community Health Councils in Wales
  British National Formulary
  Care Quality Commission
  Department of Health, Social Services and Public Safety for Northern Ireland
  Healthcare Improvement Scotland
  Medicines and Healthcare products Regulatory Agency
  National Association of Primary Care
  National Pharmacy Association
  NHS Confederation
  Scottish Medicines Consortium
  Welsh Government
  Welsh Health Specialised Services Committee
Relevant research groups Cochrane Lung Cancer Group
  Cochrane UK
  Genomics England
  Institute of Cancer Research
  MRC Clinical Trials Unit
  National Institute for Health Research

Timeline

Key events during the development of the guidance:

Date Update
10 July 2024 Invitation to participate
25 April 2024 Please note that following on from conversation between NICE and the company, the timelines for this appraisal have been scheduled and the appraisal is now anticipated to begin in early July 2024 when we will write to you about how you can get involved.
13 February 2024 - 12 March 2024 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators: 3949
13 February 2024 In progress. Scoping commencing
12 February 2024 Committee meeting
18 August 2022 Suspended. As you will be aware, the Department for Health & Social Care has asked NICE to carry out a Single Technology Appraisal of Cemiplimab with chemotherapy for untreated advanced or metastatic non-small-cell lung cancer [ID3949]. For information the company have advised that they will not be making a submission. Therefore, in collaboration with the company, NICE has suspended this evaluation from its current work programme. As this evaluation has been referred NICE will continue to monitor any development and will update interested parties if the situation changes.

For further information on our processes and methods, please see our CHTE processes and methods manual