Suggested remit: To appraise the clinical and cost effectiveness of obicetrapib monotherapy within its marketing authorisation for treating primary hypercholesterolaemia or mixed dyslipidaemia. To appraise the clinical and cost effectiveness of obicetrapib–ezetimibe (fixed dose combination) within its marketing authorisation for treating primary hypercholesterolaemia or mixed dyslipidaemia.

Status:
In progress
Technology type:
Medicine
Decision:
Selected
Reason for decision:
Anticipate the topic will be of importance to patients, carers, professionals, commissioners and the health of the public to ensure clinical benefit is realised, inequalities in use addressed, and help them make the best use of NHS resources
Process:
STA Standard
ID number:
6519

Provisional Schedule

Committee meeting: 1:
04 August 2026
Expected publication:
14 October 2026

Project Team

Project lead
Leena Issa

Email enquiries

If you have any queries please email TACommC@nice.org.uk


External Assessment Group:
BMJ Technology Assessment Group (BMJ-TAG), BMJ

Stakeholders

Companies sponsors
Menarini (obicetrapib, obicetrapib–ezetimibe)
Others
Department of Health and Social Care
 
NHS England
Patient carer groups
Blood Pressure UK
 
Cardiac Risk in the Young
 
Cardiovascular Care Partnership
 
Circulation Foundation
 
Gene People
 
Genetic Alliance UK
 
HEART UK
 
Metabolic Support UK
 
Pulmonary Hypertension Association UK
 
Pumping Marvellous Foundation
 
South Asian Health Foundation
 
Specialised Healthcare Alliance
 
Stroke Association
Professional groups
Association of Genetic Nurses & Counsellors
 
British & Irish Hypertension Society
 
British and Irish Association of Stroke Physicians
 
British Association for Nursing in Cardiovascular Care
 
British Association of Endocrine and Thyroid Surgeons
 
British Atherosclerosis Society
 
British Cardiovascular Society
 
British Dietetic Association
 
British Geriatrics Society
 
British Heart Foundation
 
British Inherited Metabolic Disease Group
 
British Nuclear Cardiology Society
 
British Society for Gene and Cell Therapy
 
British Society for Genetic Medicine
 
British Society for Haematology
 
British Society for Haemostasis and Thrombosis
 
British Society for Heart Failure
 
British Society for Paediatric Endocrinology and Diabetes
 
British Society of Cardiovascular Imaging
 
British Thoracic Society
 
Clinical Leaders of Thrombosis
 
National Heart and Lung Institute
 
National Metabolic Biochemistry Network
 
Neonatal and Paediatric Pharmacy Group
 
Primary Care Cardiovascular Society
 
Royal College of Emergency Medicine
 
Royal College of General Practitioners
 
Royal College of Nursing
 
Royal College of Paediatrics and Child Health
 
Royal College of Pathologists
 
Royal College of Physicians
 
Royal Pharmaceutical Society
 
Royal Society of Medicine
 
Society for Cardiological Science & Technology
 
Society for Endocrinology
 
Society for Vascular Technology of Great Britain and Ireland
 
Society of Vascular Nurses
 
UK Clinical Pharmacy Association
 
Vascular Society of Great Britain & Ireland
Associated public health groups
Public Health Wales
 
UK Health Security Agency
Comparator companies
Amarox (atorvastatin, rosuvastatin)
 
Amgen (evolocumab)
 
Aspire Pharma (fluvastatin)
 
AstraZeneca (rosuvastatin)
 
Aurobindo Pharma - Milpharm (atorvastatin, ezetimibe, pravastatin, rosuvastatin, simvastatin)
 
Biocon Pharma (rosuvastatin)
 
Brown & Burk (atorvastatin, rosuvastatin, simvastatin)
 
Daiichi Sankyo (bempedoic acid)
 
Dr. Reddy's Laboratories (atorvastatin)
 
Flamingo Pharma (atorvastatin)
 
Glenmark Pharmaceuticals Europe (ezetimibe, rosuvastatin)
 
Krka (atorvastatin, ezetimibe, rosuvastatin)
 
MSN Laboratories Europe (atorvastatin, rosuvastatin)
 
Mylan (atorvastatin)
 
Novartis pharmaceuticals (inclisiran)
 
Novumgen (rosuvastatin)
 
Organon Pharma (ezetimibe, simvastatin)
 
Rivopharm (ezetimibe)
 
Rosemont Pharmaceuticals (atorvastatin, simvastatin)
 
Sandoz (atorvastatin, ezetimibe, fluvastatin, rosuvastatin, simvastatin)
 
Sanofi (alirocumab)
 
Sun Pharmaceuticals (atorvastatin, rosuvastatin, simvastatin)
 
Thame Laboratories (rosuvastatin)
 
Zentiva (atorvastatin, ezetimibe, rosuvastatin)
General commentators
All Wales Therapeutics and Toxicology Centre
 
Allied Health Professionals Federation
 
Board of Community Health Councils in Wales
 
British National Formulary
 
Care Quality Commission
 
Department of Health - Northern Ireland
 
Healthcare Improvement Scotland
 
Medicines and Healthcare products Regulatory Agency
 
National Association of Primary Care
 
National Pharmacy Association
 
NHS Confederation
 
NHS Wales Joint Commissioning Committee
 
Scottish Medicines Consortium
 
Welsh Government
Relevant research groups
British Society for Cardiovascular Research
 
Cardiac and Cardiology Research Department, Barts
 
Cochrane Heart, Stroke and Circulation Thematic Group
 
Cochrane Metabolic & Endocrine Disorders Group
 
European Council for Cardiovascular Research
 
Genomics England
 
Heart Research UK
 
MRC Clinical Trials Unit
 
National Centre for Cardiovascular Preventions and Outcomes
 
National Institute for Health & Care Research
 
Wellcome Trust

Related links

Timeline

Key events during the development of the guidance:

Date Update
05 January 2026 Invitation to participate
04 November 2025 - 02 December 2025 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators: 6519
04 November 2025 In progress. Scoping commencing
16 April 2025 Referral
14 November 2024 Awaiting development. Status change linked to Topic Selection Decision being set to Selected

For further information on our processes and methods, please see our CHTE processes and methods manual