Update information

Update information

December 2021: We reviewed the evidence on fixed and age-adjusted thresholds for PSA testing and updated recommendation 1.6.3.

January 2021: We amended recommendation 1.3.4 to include the full list of criteria for faecal testing. Faecal testing should also be offered to people without rectal bleeding aged 50 or over with unexplained abdominal pain or weight loss, or to adults under 60 with changes in bowel habit or iron-deficiency anaemia. The tables of symptoms and findings have been updated to match these changes.

September 2020: Recommendation 1.3.4 was amended to clarify when to offer faecal testing for colorectal cancer to adults without rectal bleeding. The tables on abdominal and pelvic pain, change in bowel habit and primary care investigations were updated in line with this. The wording in some recommendations was edited to incorporate text previously in footnotes.

July 2017: Recommendation 1.3.4 was replaced by NICE diagnostics guidance on quantitative faecal immunochemical tests to guide referral for colorectal cancer in primary care. Recommendation 1.3.1 was amended to remove a link to recommendation 1.3.4. In December 2017, the wording of 1.3.4 was clarified, and the tables on abdominal and pelvic pain, change in bowel habit and primary care investigations updated in line with this.

June 2016: Recommendations 1.3.1 and 1.3.2 have been changed to say 'adults' instead of 'people' to more accurately reflect the populations they cover.

June 2015: This guideline updates and replaces NICE guideline CG27 (published June 2005).

Recommendations are marked as [2021], [2020], [2015], [2011], [2011, amended 2020] or [2005]:

  • [2021] indicated that the evidence has been reviewed and the recommendation has been updated in 2021.

  • [2020] indicates that the evidence has been reviewed and the recommendation has been added or updated in 2020.

  • [2011, amended 2020] indicates that the wording has been changed but the evidence has not been reviewed since 2020.

  • [2015], [2005] or [2011] indicates the date that the evidence was last reviewed.

Minor changes since publication

October 2021: In recommendation 1.12.2 we added a cross-reference to NICE's guideline on suspected neurological conditions for advice for children who have new-onset squint with an absent red reflex. See the surveillance report for more information. We also added a link to NICE's guideline on babies, children and young people's experience of healthcare in the sections on childhood cancers and symptoms in children and young people.

ISBN: 978‑1‑4731‑1164‑6

  • National Institute for Health and Care Excellence (NICE)