Intracytoplasmic sperm injection (ICSI)

1.50 Intracytoplasmic sperm injection

1.50.1

Offer ICSI using surgically retrieved sperm or frozen–thawed oocytes. [2026]

1.50.2

Consider ICSI:

  • if the partner with male reproductive organs has abnormal semen parameters, taking into account the severity

  • if a previous in vitro fertilisation (IVF) treatment cycle has resulted in failed fertilisation or a very low fertilisation rate. [2026]

1.50.3

Do not use ICSI for non-male factor fertility problems if the semen parameters are normal. [2026]

1.50.4

Do not use intracytoplasmic morphologically selected sperm injection (IMSI) as an adjunct to ICSI. [2026]

1.50.5

Do not use physiological intracytoplasmic sperm injection (PICSI) in preference to standard ICSI. [2026]

For a short explanation of why the committee made these recommendations and how they might affect practice, see the rationale and impact section on intracytoplasmic sperm injection.

Full details of the evidence and the committee's discussion are in: