Context
Because of the changes to the International Myeloma Working Group definition of smouldering myeloma, it was not possible to make any recommendations for clinical practice on managing this condition. The new definition has changed how smouldering myeloma and myeloma are differentiated, and there is currently no evidence available that is using the new definitions.
This guideline covers adults (aged 16 years and over):
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who are referred to secondary care with suspected myeloma
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with newly diagnosed or relapsed myeloma (including high‑risk myeloma and primary plasma cell leukaemia).
This guideline does not cover people who have:
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a solitary plasmacytoma without myeloma
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amyloid light‑chain amyloidosis in the absence of myeloma
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paraproteins secondary to other conditions.