2 Information about pirtobrutinib

Marketing authorisation indication

2.1

Pirtobrutinib (Jaypirca, Eli Lilly & Company) is indicated as monotherapy for 'the treatment of adult patients with relapsed or refractory chronic lymphocytic leukaemia (CLL) who have been previously treated with a BTK inhibitor'.

Dosage in the marketing authorisation

Price

2.3

The list price for pirtobrutinib is £2,081.50 for a 28-pack of 50 mg tablets and £8,325.00 for a 56-pack of 100 mg tablets (excluding VAT; BNF online accessed June 2026).

2.4

The company has a commercial arrangement. This makes pirtobrutinib available to the NHS with a discount. The size of the discount is commercial in confidence.

Sustainability