Sunitinib (Sutent, Pfizer) is an inhibitor of a group of closely related tyrosine kinase receptors. It inhibits VEGF/PDGF receptors on cancer cells, vascular endothelial cells and pericytes, inhibiting the proliferation of tumour cells and the development of tumour blood vessels. Sunitinib has a UK marketing authorisation for the treatment of people with advanced and/or metastatic renal cell carcinoma (RCC).
Sunitinib is contraindicated in people who have hypersensitivity to sunitinib malate or to any of the excipients. The summary of product characteristics (SPC) lists the following conditions that may be associated with sunitinib treatment: skin and tissue problems, gastrointestinal events, haemorrhage, hypertension, haematological problems, venous thromboembolic events, pulmonary embolism and hypothyroidism. For full details of side effects and contraindications, see the SPC.
Sunitinib is administered orally. The recommended dosage is 50 mg once daily for 4 consecutive weeks with a 2-week rest period (that is, a complete treatment cycle of 6 weeks). The dose may be adjusted in steps of 12.5 mg according to tolerability (dose range 25 mg to 75 mg). The price for a 28-capsule pack of 50-mg capsules is £2,730.76 (excluding VAT; Pfizer). This updated list price was confirmed by the manufacturer in September 2025 and replaces the previously agreed patient access scheme for sunitinib. Costs of subsequent treatment cycles may vary in different settings because of negotiated procurement discounts.