Evidence-based recommendations on temozolomide (Temodal) for malignant glioma in children over 3 years, young people and adults.

March 2016: The wording of recommendation 1.1 has been updated in line with NICE’s wording conventions. Recommendations 1.2 and 1.3 for temozolomide for the first-line chemotherapy treatment of malignant glioma when primary therapy (surgery and/or radiotherapy) has failed have been withdrawn and are updated by recommendation 1.1 of NICE’s technology appraisal guidance on carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma (TA121).

Guidance development process

How we develop NICE technology appraisal guidance

Next review date: this guidance will be reviewed if there is new evidence or safety concerns.

Your responsibility

The recommendations in this guidance represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, health professionals are expected to take this guidance fully into account, alongside the individual needs, preferences and values of their patients. The application of the recommendations in this guidance is at the discretion of health professionals and their individual patients and do not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.

Commissioners and/or providers have a responsibility to provide the funding required to enable the guidance to be applied when individual health professionals and their patients wish to use it, in accordance with the NHS Constitution. They should do so in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities.

Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible.