3 Evidence

3 Evidence

3.1 The appraisal committee (section 6) considered evidence submitted by Bristol-Myers Squibb and a review of this submission by the evidence review group. This appraisal was a Cancer Drugs Fund partial reconsideration of the published NICE technology appraisal guidance on dasatinib, nilotinib and standard-dose imatinib for the first-line treatment of chronic myeloid leukaemia. Sections 4.1 to 4.28 reflect the committee's consideration of the evidence submitted in the original appraisal (NICE technology appraisal guidance 251). Sections 4.29 to 4.32 reflect the committee's consideration of the additional evidence submitted for the Cancer Drugs Fund reconsideration. It focused on a cost-minimisation analysis using a revised patient access scheme, which provides a simple discount to the list price of dasatinib. The level of the discount is commercial in confidence.

3.2 See the committee papers for full details of the Cancer Drugs Fund reconsideration evidence and the history for full details of the evidence used for NICE's original technology appraisal guidance on dasatinib, nilotinib and standard-dose imatinib for the first-line treatment of chronic myeloid leukaemia.

  • National Institute for Health and Care Excellence (NICE)