Information for the public

Inclisiran (Leqvio) is available on the NHS as a possible treatment for primary hypercholesterolaemia (heterozygous familial and non-familial) or mixed dyslipidaemia alongside dietary changes in adults. It is recommended if:

  • the person has ever had:
    • acute coronary syndrome (such as myocardial infarction or unstable angina needing hospitalisation)
    • procedures to help blood flow in the arteries of the heart
    • coronary heart disease
    • ischaemic stroke or
    • peripheral arterial disease, and
  • the person has low‑density lipoprotein cholesterol concentrations that are persistently 2.6 mmol/l or more even after they’ve had the highest dose of lipid lowering therapies that they can have. This can be statins with or without other lipid-lowering therapies or just other lipid-lowering therapies if they can’t have statins.

Is this treatment right for me?

Your healthcare professionals should give you clear information, talk with you about your options and listen carefully to your views and concerns. Your family can be involved too, if you wish. Read more about making decisions about your care.

Questions to think about

  • How well does it work compared with other treatments?
  • What are the risks or side effects? How likely are they?
  • How will the treatment affect my day-to-day life?
  • What happens if the treatment does not work?
  • What happens if I do not want to have treatment? Are there other treatments available?

Information and support

The NHS website may be a good place to find out more.

These organisations can give you advice and support: Heart UK, 0162 877 7046

You can also get support from your local Healthwatch.

NICE is not responsible for the quality or accuracy of any information or advice provided by these organisations.

ISBN: 978-1-4731-4285-5


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