2 Information about polatuzumab vedotin

Marketing authorisation indication

2.1 Polatuzumab vedotin (Polivy, Roche) in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone is indicated for 'the treatment of adult patients with previously untreated diffuse large B-cell lymphoma (DLBCL)'.

Dosage in the marketing authorisation

2.2 The dosage schedule is available in the summary of product characteristics for polatuzumab vedotin.


2.3 Polatuzumab vedotin costs £2,370 per 30 mg vial or £11,060 per 140 mg vial (excluding VAT, BNF online accessed December 2022).

2.4 The company has a commercial arrangement. This makes polatuzumab vedotin available to the NHS with a discount. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.

  • National Institute for Health and Care Excellence (NICE)