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    The content on this page is not current guidance and is only for the purposes of the consultation process.

    Validity and generalisability of the studies

    • There are no RCTs comparing the effect of RFA alone with other treatments for painful vertebral metastases.

    • Limited evidence included was mainly from small prospective and retrospective studies with short to medium term follow up.

    • RFA systems with different ablation methods (bipolar or monopolar RF electrodes) and temperatures, protocols were used in studies.

    • Outcomes were variable patient reported outcomes and are subject to high risk of bias.

    • Limited studies show that RFA is likely to provide effective short to mid-term (1 week to 6 months) pain relief.