Interventional procedure overview of temperature control to improve neurological outcomes after cardiac arrest
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Methods
NICE identified studies and reviews relevant to temperature control to improve neurological outcomes after cardiac arrest from the medical literature. The following databases were searched between the date they started to 30-08-2022: MEDLINE, PREMEDLINE, EMBASE, Cochrane Library and other databases. Trial registries and the internet were also searched (see the literature search strategy). Relevant published studies identified during consultation or resolution that are published after this date may also be considered for inclusion.
The following inclusion criteria were applied to the abstracts identified by the literature search.
Publication type: only systematic reviews, meta-analysis and RCTs on TTM were included. Secondary analyses or sub-studies of larger RCTs, non-randomised studies, observational studies, case reports, reviews, abstracts, editorials, letters to the editor, commentary and laboratory or animal studies, were excluded and so were conference abstracts, unless they reported specific adverse events that not available in the published literature.
Adult patients with cardiac arrest.
Intervention or test: temperature control/targeted temperature management.
Outcome: articles were retrieved if the abstract contained information relevant to the safety, efficacy (mainly focusing on neurological outcomes), or both.
If selection criteria could not be determined from the abstracts the full paper was retrieved.
Potentially relevant studies not included in the main evidence summary are listed in the section on other relevant studies.
Find out more about how NICE selects the evidence for the committee.
Databases | Date searched | Version/files |
MEDLINE (Ovid) | 30/08/2022 | 1946 to August 29, 2022 |
MEDLINE In-Process (Ovid) | 30/08/2022 | 1946 to August 29, 2022 |
MEDLINE Pubs ahead of print (Ovid) | 30/08/2022 | August 29, 2022 |
EMBASE (Ovid) | 30/08/2022 | 1974 to 2022 August 29 |
EMBASE Conference (Ovid) | 30/08/2022 | 1974 to 2022 August 29 |
Cochrane Database of Systematic Reviews – CDSR (Cochrane Library) | 30/08/2022 | Issue 8 of 12, August 2022 |
Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library) | 30/08/2022 | Issue 8 of 12, August 2022 |
International HTA database (INAHTA) | 30/08/2022 | - |
Trial sources searched April 2022
Clinicaltrials.gov
ISRCTN
WHO International Clinical Trials Registry
Websites searched April 2022
National Institute for Health and Care Excellence (NICE)
NHS England
Food and Drug Administration (FDA) - MAUDE database
Australian Safety and Efficacy Register of New Interventional Procedures – Surgical (ASERNIP – S)
Australia and New Zealand Horizon Scanning Network (ANZHSN)
General internet search
The following search strategy was used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.
1 Hypothermia, Induced/ 21,660
2 Cold Temperature/ 54,122
3 TTM.tw. 1,630
4 (Target adj4 temperat* adj4 manage*).tw. 191
5 ((Therapeut* or Protect* or Induc*) adj4 hypother*).tw. 9,937
6 (temperature adj4 (manage* or target*) adj4 (cool* or chill* or reduce* or low* or cold*)).tw. 277
7 (control* adj4 normoth*).tw. 562
8 (Intravascular adj4 cool*).tw. 95
9 ((Cool* or chill*) adj4 (device or blank*)).tw. 968
10 or/1-9 81,550
11 Heart Arrest/ 31,643
12 Cardiopulmonary Resuscitation/ 20,610
13 ((cardiac* or heart* or postcard*) adj4 arrest).tw. 36,300
14 (cardiopulmon* adj4 resuscitat*).tw. 15,313
15 Out-of-Hospital Cardiac Arrest/ 6,405
16 (out of hospital adj4 (cardiac* or heart*) adj4 arrest*).tw. 6,814
17 or/11-16 62,450
18 10 and 17 4,468
19 Thermogard.tw. 9
20 RhinoChill.tw. 15
21 Medicool.tw. 0
22 Arctic Sun.tw. 34
23 coolgard.tw. 23
24 or/19-23 77
25 18 or 24 4,503
26 Animals/ not Humans/ 5,007,751
27 25 not 26 3,716
28 limit 27 to english language 3,368
29 limit 28 to ed=20170101-20220930 1,173
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