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Guidance assessment consultation document for In-situ abdominal normothermic regional perfusion to preserve donor livers during retrieval for transplantation after controlled circulatory death

When a liver is donated after treatment has been withdrawn and the donor's heart stops beating (controlled circulatory death), the liver may be damaged. This is because it does not receive blood with oxygen for a short period. In this procedure, a machine puts oxygen into the donor's blood and pumps it through the organs in their abdomen (regional perfusion) at normal body temperature (normothermic). The aim is to keep supplying the liver with oxygen while it is still in the donor's body (in situ) to reduce damage before transplantation.

NICE interventional procedures guidance applies to the NHS in England, Wales and Northern Ireland.