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  • Question on Consultation

    Has all of the relevant evidence been taken into account?

  • Question on Consultation

    Are the summaries of clinical and cost effectiveness reasonable interpretations of the evidence?

  • Question on Consultation

    Are the recommendations sound and a suitable basis for guidance to the NHS?

  • Question on Consultation

    Are there any equality issues that need special consideration and are not covered in the medical technology consultation document?

Guidance assessment consultation document for In-situ abdominal normothermic regional perfusion to preserve donor livers during retrieval for transplantation after controlled circulatory death

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Guidance development process

NICE interventional procedures guidance evaluates procedures used for treatment or diagnosis. It provides evidence-based recommendations on the safety and efficacy of these procedures. The guidance supports healthcare professionals and commissioners to ensure that patients get the best possible care. By reviewing clinical evidence and considering patient outcomes, NICE aims to improve patient safety and treatment choices in the NHS.

Find out more on the NICE webpage on interventional procedures guidance.

NICE is producing this guidance on in-situ abdominal normothermic regional perfusion to preserve donor livers during retrieval for transplantation after controlled circulatory death in the NHS. The interventional procedures advisory committee has considered the evidence and the views of clinical and patient experts.

This document has been prepared for consultation with the stakeholders. It summarises the evidence and views that have been considered, and sets out the recommendations made by the committee. NICE invites comments from the stakeholders for this evaluation and the public. This document should be read along with the evidence.

The committee is interested in receiving comments on the following:

  • Has all of the relevant evidence been taken into account?

  • Are the summaries of safety and efficacy reasonable interpretations of the evidence?

  • Are the recommendations sound and a suitable basis for guidance to the NHS?

  • Are there any aspects of the recommendations that need particular consideration to ensure we avoid unlawful discrimination against any group of people on the grounds of age, disability, gender reassignment, pregnancy and maternity, race, religion or belief, sex or sexual orientation?

After consultation:

  • Based on the consultation comments received, the committee may meet again.

  • If committee meets again it will consider the evidence, this evaluation consultation document and comments from stakeholders.

  • The committee will then prepare the final draft guidance, which will go through a resolution process before the final guidance is agreed.

Note that this document is not NICE's final guidance on in-situ abdominal normothermic regional perfusion to preserve donor livers during retrieval for transplantation after controlled circulatory death. The recommendations in section 1 may change after consultation.

More details are available in NICE's interventional procedures programme manual and NICE's HealthTech programme manual.

Key dates:

Closing date for comments: 28 July 2026

Second committee meeting (if needed): 10 September 2026