2019 surveillance of chest pain of recent onset: assessment and diagnosis (NICE CG95)
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Research recommendations
1 Cost-effectiveness of multislice CT coronary angiography for ruling out obstructive CAD in people with troponin-negative acute coronary syndromes
Is multislice CT coronary angiography a cost-effective first-line test for ruling out obstructive CAD in people with suspected troponin-negative acute coronary syndromes?
Summary of findings
No new evidence relevant to the research recommendation was found and no ongoing studies were identified.
2 Refining the use of telephone advice in people with chest pain
In what circumstances should telephone advice be given to people calling with chest pain? Is the appropriateness influenced by age, sex or symptoms?
Summary of findings
No new evidence relevant to the research recommendation was found and no ongoing studies were identified.
3 Establishing a national registry for people who are undergoing initial assessment for stable angina
Can a national registry of people presenting with suspected angina be established to allow cohort analysis of treatments, investigations and outcomes in this group? Such a registry would provide a vital resource for a range of important research projects, including:
development and validation of a new score for assessing the pre-test probability of disease, addressing outstanding uncertainties in the estimation of the pre-test probability of CAD based on simple measures made at initial assessment (history, examination, routine bloods, resting 12‑lead ECG)
assessment of the extent to which new circulating biomarkers add additional information to measures made at initial assessment
provision of a framework for trial recruitment without significant work-up bias allowing evaluation of the diagnostic and prognostic test performance of CT‑based, MR, echocardiography and radionuclide technologies.
Summary of findings
No new evidence relevant to the research recommendation was found and no ongoing studies were identified.
4 Information about presenting and explaining tests
All people presenting with chest pain will need to decide whether to accept the diagnostic and care pathways offered. How should information about the diagnostic pathway and the likely outcomes, risks and benefits, with and without treatment, be most effectively presented to particular groups of people, defined by age, ethnicity and sex?
Summary of findings
No new evidence relevant to the research recommendation was found and no ongoing studies were identified.
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