Cryoprecipitate transfusion

People have the right to be involved in discussions and make informed decisions about their care, as described in NICE's information on making decisions about your care.

Making decisions using NICE guidelines explains how we use words to show the strength (or certainty) of our recommendations, and has information about prescribing medicines (including off-label use), professional guidelines, standards and laws (including on consent and mental capacity), and safeguarding.

Healthcare professionals should follow our general guidelines for people delivering care:

1.11 Thresholds and targets

1.11.1

Consider cryoprecipitate transfusions for people without major haemorrhage who have:

clinically significant bleeding and
a fibrinogen level below 1.5 g/litre. [2015]

1.11.2

Do not offer cryoprecipitate transfusions to correct the fibrinogen level in people who:

are not bleeding and
are not having invasive procedures or surgery with a risk of clinically significant bleeding. [2015]

1.11.3

Consider prophylactic cryoprecipitate transfusions for people with a fibrinogen level below 1.0 g/litre who are having invasive procedures or surgery with a risk of clinically significant bleeding. [2015]

1.12 Doses

1.12.1

Use an adult dose of 2 pools when giving cryoprecipitate transfusions (for children, use 5 to 10 ml/kg up to a maximum of 2 pools). [2015]

1.12.2

Reassess the person's clinical condition, repeat the fibrinogen level measurement and give further doses if needed. [2015]