Fresh frozen plasma transfusion

People have the right to be involved in discussions and make informed decisions about their care, as described in NICE's information on making decisions about your care.

Making decisions using NICE guidelines explains how we use words to show the strength (or certainty) of our recommendations, and has information about prescribing medicines (including off-label use), professional guidelines, standards and laws (including on consent and mental capacity), and safeguarding.

Healthcare professionals should follow our general guidelines for people delivering care:

1.9 Thresholds and targets

1.9.1

Only consider fresh frozen plasma transfusion for people with clinically significant bleeding but without major haemorrhage if they have abnormal coagulation test results (for example, prothrombin time ratio or activated partial thromboplastin time ratio above 1.5). [2015]

1.9.2

Do not offer fresh frozen plasma transfusions to correct abnormal coagulation in people who:

  • are not bleeding (unless they are having invasive procedures or surgery with a risk of clinically significant bleeding)

  • need reversal of a vitamin K antagonist. [2015]

1.9.3

Consider prophylactic fresh frozen plasma transfusions for people with abnormal coagulation who are having invasive procedures or surgery with a risk of clinically significant bleeding. [2015]

1.10 Doses

1.10.1

Reassess the person's clinical condition and repeat the coagulation tests after fresh frozen plasma transfusion to ensure that they are getting an adequate dose, and give further doses if needed. [2015]