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Suspected sepsis in people aged 16 or over: recognition, assessment and early management

  • NICE guideline
  • Reference number: NG253
  • Published:  19 November 2025

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  • Guidance
  • Tools and resources
  • Information for the public
  • Evidence
  • History
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  • Overview
  • Could this be sepsis?
  • Face-to-face assessment
  • Evaluating risk
  • Managing suspected sepsis
  • Antibiotic therapy, intravenous fluid and oxygen
  • Finding and controlling the source of infection
  • Information and support for all people with suspected sepsis
  • Training and education
  • Terms used in this guideline
  • Recommendations for research
  • Rationale and impact
  • Finding more information and committee details
  • Update information

Finding more information and committee details

To find NICE guidance on related topics, including guidance in development, see the NICE topic pages on sepsis and antimicrobial stewardship.

For full details of the evidence and the guideline committee's discussions, see the evidence reviews. You can also find information about how the guideline was developed, including details of the committee.

NICE has produced tools and resources to help you put this guideline into practice. For general help and advice on putting our guidelines into practice, see resources to help you put NICE guidance into practice.


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