Guidance on the use of fludarabine for B-cell chronic lymphocytic leukaemia

Stage 0

Lymphocytosis in blood and bone marrow only

12 years

Stage I

Lymphocytosis plus lymphadenopathy

7 years

Stage II

Lymphocytosis plus splenomegaly or hepatomegaly

7 years

Stage III

Lymphocytosis plus anaemia (Hb < 110 g/L)

< 1 year

Stage IV

Lymphocytosis plus thrombocytopenia

(platelets < 100 x 10⁹/L)

< 1 year

Stage A

< 3 sites involved,

Hb > 100 g/L, platelets > 100 x 10⁹/L

9 years

Stage B

> 3 sites involved,

Hb > 100 g/L, platelets > 100 x 10⁹/L

5 years

Stage C

Hb < 100 g/L, platelets > 100 x 10⁹/L

2 years