We are actively involved in a range of methodological research and other projects.
Our projects and partnerships help us to keep improving how NICE works. They also help us anticipate and adapt to policy developments, including changes in health and social care delivery.
Current research and projects
NICE listens is a new programme of public engagement. It's been developed to give us an understanding of public opinion on moral, ethical and social value issues.
Using best practice methods, NICE listens will invite members of the public to take part in a ‘citizen’s jury’ style event. This will give those involved time to learn and become familiar with the topic area, before discussing it in detail. An independent organisation will facilitate the process, to make sure it's fair and transparent. They'll produce a final report, which will be presented to our executive team and public board.
The first NICE listens will focus on health inequalities. Striking a balance between maximizing health gains and addressing health inequalities is challenging. It requires active engagement with the public to understand the social value judgements involved. We need to gather up to date public opinion in this area, to help us put together a policy response. The results from this first project are expected to be available in January 2022.
NICE listens is a collaborative project between the science, research and policy team and the public involvement programme.
We’re developing better methods for measuring and valuing health-related quality of life in children and young people. The aim is to ensure that we use economic models that reflect the experiences of children and young people with the relevant condition or disease.
Reports from our Decision Support Unit show that a range of methods are used in NICE appraisals which include this age group. But further research is needed before NICE can recommend which measures should be used in the future.
We are collaborating with several researchers who are developing and evaluating methods for measuring and valuing health-related quality of life in children and young people. If you'd like to partner with NICE, please contact us.
The ERA4TB project’s main objective is to create a European open platform to accelerate the development of new regimens for the treatment of tuberculosis. The project consortium will do this through a new community-focused platform on tuberculosis translational research and knowledge integration.
During the project, NICE will act as an interface with key stakeholders, mainly HTAs, regulatory authorities and patients, to maximise uptake and impact of ERA4TB’s results. The project activity will complement NICE’s ongoing work in the area of antimicrobial resistance.
The partnership between NICE and Flatiron Health aims to explore if and how real-world evidence can inform the clinical and cost effectiveness of health technologies.
An initial research project will compare survival estimates from clinical trials to survival data observed in actual patient records to evaluate opportunities to reduce uncertainty in the estimation of long-term outcomes.
The collaboration will test how additional sources of evidence could complement trial and research data in NICE’s technology appraisals, especially in helping to resolve uncertainty in the evidence.
The GetReal Initiative is an Innovative Medicines Initiative (IMI) project which aims to develop tangible solutions to key challenges associated with using real-world data in drug development and subsequent regulatory and health technology assessment.
The project will establish a real-world evidence Think Tank, which will gather international thought leaders to discuss, assess and give recommendations on the opportunities and barriers to the generation, use and acceptability of real-world evidence.
This project follows on from successful completion in March 2017 of the IMI GetReal project on the use of real-world evidence in effectiveness research.
The Extending the QALY (E-QALY) project aims to develop a broad measure of quality of life for use in economic evaluations across health and social care, for both patients and carers.
The project will explore the importance of non-health aspects, such as social and emotional wellbeing, in addition to physical and mental health so that important benefits, other than those related to health, are captured.
By developing a new measure of quality of life it will be possible to undertake more meaningful economic evaluations that incorporate the value of wider societal benefits, which are currently excluded from existing methods.
IMPACT HTA proposes new and improved methods, tools and guidance for decision-makers across ten research areas in the context of health technology assessment and health system performance measurement. This will contribute to the understanding of costs and health outcomes variations within and across countries and to costs and health outcomes data integration from different sources.
NICE’s role in the project includes assessing the performance of a range of statistical methods used to analyse non-randomised studies, and provide recommendations on which methods are likely to produce valid and unbiased estimates of relative effectiveness of interventions.
The methodological recommendations produced in this project will be useful for informing future updates of NICE’s methods guides in relation to the use of non-randomised studies, sometimes referred to as ‘real-world studies’.
The EHDEN project aims to set up a European federated network of data sources standardised to a common data model. The network will enable observational research and the generation of high-quality real-world evidence through open collaboration.
NEURONET is a coordination and support action project which provides support to a broad portfolio of IMI projects on neuro-degenerative diseases. The project will identify research gaps, look at the impact of the IMI neuro-degenerative portfolio, and will facilitate links with related initiatives in Europe and worldwide.
A key output from the project is an interactive Knowledge Base which brings together key information about the 18 projects in the IMI neuro-degenerative diseases portfolio, including links to project publications, tools and deliverable reports.
The Knowledge Base is an integral part of NEURONET’s endeavour to boost collaboration across the research portfolio and to enhance the visibility of the portfolio with related initiatives in Europe and worldwide.
VALUE-Dx will facilitate and accelerate the rigorous assessment and implementation of diagnostic technologies into healthcare settings. It will to this by establishing the methods, processes and approaches needed to understand, evaluate, and assess the value of diagnostics in the context of optimising antibiotic use. VALUE-Dx has a particular focus on community-acquired acute respiratory tract infections (CA-ARTI).
The project will produce recommendations on how to improve existing pricing and funding policies to ensure timely accessibility of cost-effective diagnostics to reduce anti-microbial resistance (AMR).
HTx: Next Generation Health Technology Assessment to support patient centred, societally oriented, real-time decision-making on access to and reimbursement for health technologies throughout Europe
The project aims to create and test a framework for ‘next generation’ health technology assessment that will provide solutions for a broad range of challenges, such as personalised medicine, combination therapies, big data and artificial intelligence (AI).
The science policy and research team is leading NICE’s work on whether to adopt the EQ-5D-5L valuation set for England. Our blog explains why this work matters and explains our next steps.
For more information see this blog.
HARMONY (Big Data for Better Outcomes): Healthcare Alliance for Resourceful Medicines Offensive against Neoplasms in Haematology
The HARMONY alliance aims to use big data and big data analytics to deliver knowledge that will improve the care of patients with several blood cancers. Specifically, this project will gather high quality patient data into a database where it will be harmonised and analysed to improve patient care and increase treatment options The project’s database will also help improve decision making for policy makers and clinicians, to help them to give the right treatment to the right patient at the right time.
The project expands the focus to additional blood diseases that were not covered by HARMONY and further deploys artificial intelligence techniques on an expanded big data platform.
Past research and projects
ADAPT-SMART aimed to design new collaborative approaches to the development of medicines, known as Medicines Adaptive Pathways to Patients (MAPPs). We've played a leading role in this and other projects, and now engage with pharmaceutical companies via our Office for Market Access and the Accelerated Access Collaborative.
GetReal aimed to develop a clearer understanding of how real-world evidence (RWE) can contribute to pharmaceutical research and development and healthcare decision-making.
As part of GetReal, we worked with the University of Manchester and the Association of British Pharmaceutical Industry (ABPI) to publish a report of recommendations for advancing the UK’s capability for data science research in healthcare.
We also developed the RWE Navigator, an online platform to support better understanding of the potential of RWE in the development and assessment of new drugs.
In April 2015, NICE launched an exploratory study to highlight key issues in the evaluation of regenerative medicines and consider the suitability (or otherwise) of current methods.
The study responds to recommendations from the Department of Health Regenerative Medicine Expert Group (RMEG).
NICE has worked in collaboration with the Centre for Reviews and Dissemination and Centre for Health Economics, University of York, who have produced an extensive independent report.
The NICE Regenerative Medicines and Cell Therapy report summarises key findings from the study, considers implications for NICE and makes a number of recommendations.
We worked in partnership with Myeloma UK to explore potential quantitative methods for capturing and using patient preferences within HTA decision-making. This initial ‘proof of concept’ project was funded by Myeloma UK and focused on patients with multiple myeloma. For more information, read our blog about patient preferences which outlines the findings from this project.
The DO>IT project was launched to provide a coordination platform for the BD4BO programme, exploiting synergies across the projects and maximising its impact on healthcare systems. With the aim to aggregate learnings and disseminate findings from the projects; develop minimum data privacy standards; engage with key stakeholders; and recommend areas for future collaborative research. The project delivered a toolkit to support the other BD4BO projects in the identification, selection and measurement of outcomes.
The ROADMAP project worked on improving real world evidence in Alzheimer’s disease. The project launched the Data Cube in 2019, that provides an interactive overview of European data sources that capture outcomes relevant for Alzheimer’s disease. Find the Data Cube here.
The European Medicines Agency approved the first histology independent cancer drug in 2019. The clinical evidence on the effectiveness of these drugs makes it hard to assess:
- the level of benefit to patients
- if the drug provides value for money to health systems such as the NHS.
We initiated methods research through the National Institute for Health Research HTA programme. This addressed the following questions:
- Can we apply our existing technology appraisal approaches and are any changes required?
- What evidence will be available at the point of initial marketing authorisation for these drugs?
- What guidance is needed to establish the evidence and analyses required to inform our recommendations?
Read the pre-publication report and recommendations from researchers at the University of York and the University of Sheffield.
We have a memorandum of understanding with Manchester Academic Health Science Centre (MAHSC), in partnership with Health Innovation Manchester (HInM), the University of Manchester and the Greater Manchester Academic Health Science Network (GMAHSN).
The memorandum of understanding sets out a shared commitment to improving the overall health of the population through research and informing health policy and practice, as well as through the development and evaluation of health technologies. Collaboration between the three parties will also focus on teaching, training and education.
A key project which will be undertaken through the partnership is ‘Data Lab’. Building on Greater Manchester’s extensive expertise and numerous digital and data assets, the Data Lab will explore how routinely collected information, such as anonymised data derived from patient records, may be used to evaluate the effectiveness of medicines, new technologies and interventions in the development of NICE guidance.
NICE is part of a global group of organisations who want to speed up the development and delivery of new, effective and affordable drugs. The programme brings together pharmaceutical companies, academic researchers, patient advocacy groups, government agencies and other experts.
Our work with MRC MRP to prioritise methodological research topics has resulted in a variety of funding opportunities for researchers, for example: