Models for the evaluation and purchase of antimicrobials

Antimicrobial resistance (AMR) is an urgent global challenge. It causes around 700,000 deaths each year globally. That is predicted to rise to 10 million by 2050 if no action is taken.

The UK Government is committed to a 5 year action plan. This reflects the World Health Organization’s priorities for tackling AMR, and the United Nations framework for action.

The scale of the AMR threat is widely acknowledged. The COVID-19 pandemic has highlighted the need for ongoing planning for infectious diseases.

Why we need a change in approach

We're heading towards a world where antimicrobials no longer work. The drugs we already have are often used inappropriately. There have been few new antimicrobials discovered since the 1980s.

Investing in new antimicrobials is commercially unattractive. Research and development costs are high. Restrictions put in place to reduce resistance mean it is difficult for companies to see a return on their investment.

What we're doing

We will work with NHS England and NHS Improvement (NHSE&I) to test a new health technology assessment process and a new payment model. This will mean the payments made to companies are not linked to how many antimicrobials are sold.

We will select 2 products for the project. This will test the new model while ensuring access to a new antimicrobial.

Contact the AMR reimbursement project team for further information.