Methodological research helps us to keep improving the methods we use to produce guidance.  It also helps us anticipate and adapt to policy developments and changes in health and social care delivery. We are actively involved in this type of research and currently have 9 priority research topics that we are working on.

We welcome opportunities to work with you on research projects that will address any of our 9 priorities. By partnering with us, you can get unique insight into the real-life practicalities of assessing health and social care interventions.

Our priority areas

1.    Real world evidence

Our projects (such as GetReal) explore how to gather, analyse and interpret real-world evidence (data collected outside randomised controlled trials, such as observational studies or registries).

2.    Data science

We are exploring processes and systems for extracting knowledge from large data sets (such as electronic health records) to understand the opportunities that data science might offer NICE and the wider health and social care system.

3.    Adaptive pathways

Adaptive pathways are regulatory processes that allow patients early access to new and urgently needed treatments. We have played leading roles in adaptive pathways initiatives and ADAPT-SMART, and now engage with pharmaceutical companies through our Office for Market Access.

4.    Patient preferences

We are developing and testing methods for capturing patient’s preferences for different treatment options (for example, based on different side-effect profiles). Read about our project with Myeloma UK.

5.    Improving cross-sector comparisons

We are supporting research that aims to develop measures of quality of life that are suitable for interventions in health, public health and social care, under the Extending the QALY project.

6.    Expert elicitation

We are developing methods to obtain expert opinion, to support guidance development in areas where evidence is limited.

7.    Complex data visualisation

We are developing and testing visualisation aids and decision tools that will help our committees to consider and discuss complex data, and help stakeholders understand the rationale behind NICE guidance.

8.    Precision medicine

We are assessing whether NICE’s methods and processes support the uptake of precision medicine technologies and services in the NHS (such as advanced therapy medicinal products and diagnostics for reducing antimicrobial resistance).

9.    Implementation of NICE guidance

We offer a range of support to help health and social care professionals put guidance into practice. Our research aims to establish which implementation strategies are most effective.