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Developing NICE single technology appraisals (STAs)

This is a summary of how NICE develops single technology appraisals. A single technology appraisal can only cover a single technology for a single indication. See all technology appraisals currently in development.

  1. Provisional appraisal topics chosen
    The Department of Health (DH) produces a list of provisional appraisal topics.
  2. Consultees and commentators identified
    Read more about consultees and commentators.
  3. Scope prepared
    NICE works with the DH to develop a scope. The scope defines the disease, the patients and the technology covered by the appraisal and the questions it aims to answer. Consultees and commentators are requested to comment on the draft scope.
  4. Appraisal topics referred
    The DH refers technology appraisal topics to NICE. Read more about how guidance topics are chosen.
  5. Evidence submitted
    The manufacturer or sponsor of the technology is invited to provide an evidence submission. NICE also invites all non-manufacturer consultees to submit a statement on the potential clinical and cost effectiveness of a treatment.
  6. Evidence Review Group (ERG) report prepared
    NICE commissions an independent academic centre to technically review the evidence submission and prepare an ERG report.
  7. Evaluation report prepared
    This includes all of the evidence that will be looked at by the Appraisal Committee. This evidence includes:
  • the ERG report
  • written submissions
  • patient expert personal statements
  • clinical specialist personal statements
  • comments received on the ERG report.
  1. Appraisal Committee
    An independent advisory committee considers the evaluation report and hears evidence from nominated clinical experts, patients and carers. Committee discussions are held in public. Read more about the Appraisal Committee.
  2. Appraisal consultation document (ACD)if produced
    The Appraisal Committee makes its provisional recommendations in the ACD. An ACD will be produced if the recommendations from the Appraisal Committee limit the use of the technology beyond the specifications in the marketing authorisation. An ACD will also be produced if the Appraisal Committee asks NICE to seek clarification from the manufacturer or sponsor on the key evidence submitted for a technology (a 'minded no' recommendation). Consultees and commentators have four weeks to comment on the ACD. The ACD is also made available on our website so health professionals and members of the public can comment on it.
  3. Final appraisal determination (FAD) produced
    The Appraisal Committee considers the comments on the ACD if produced, then makes its final recommendations in the FAD on how the technology should be used in the NHS in England and Wales. Consultees can appeal against the final recommendations in the FAD.
  4. Guidance issued
    If there are no appeals, or an appeal is not upheld, the final recommendations are issued as NICE guidance.

Further information

This page was last updated: 21 February 2014

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Accessibility | Cymraeg | Freedom of information | Vision Impaired | Contact Us | Glossary | Data protection | Copyright | Disclaimer | Terms and conditions

Copyright 2014 National Institute for Health and Care Excellence. All rights reserved.