Rheumatoid arthritis - tocilizumab (rapid review TA198) (TA247)
Fast, easy summary view of NICE guidance on 'rheumatoid arthritis'
This guidance updates and replaces NICE technology appraisal 198 (published in August 2010).
NICE recommends tocilizumab, taken with a drug called methotrexate, as a possible treatment for some people with rheumatoid arthritis (see below).
Who can have tocilizumab?
You should be able to have tocilizumab if:
- you have tried disease-modifying anti-rheumatic drugs (DMARDs for short) but they have not worked, as long as tocilizumab is used in the same way that NICE recommends drugs called tumour necrosis factor (TNF for short) inhibitors are used in its guidance Adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis or
- you have tried DMARDs and a TNF inhibitor but they have not worked, and you cannot have rituximab for medical reasons or because of a bad reaction, as long as tocilizumab is used as in the same way that NICE recommends TNF inhibitors are used in Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a TNF inhibitor or
- you have tried TNF inhibitors and rituximab but they have not worked.
Why has NICE said this?
NICE looks at how well treatments work, and also at how well they work in relation to how much they cost the NHS. NICE recommended tocilizumab in these circumstances because it works well and its cost is justified after other drugs have been tried.
This guidance has been incorporated into the following NICE Pathways, along with other related guidance and products.
Visit the NICE Pathway: rheumatoid arthritis
This page was last updated: 07 March 2014
- Web format
- Full Guidance (PDF)
- TA247 Tocilizumab ar gyfer arthritis gwynegol: deall canllawiau NICE (fformat MS Word)
Information for the public
Implementation tools and resources
- Costing statement
- Biologic drugs for the treatment of inflammatory disease in rheumatology, dermatology and gastroenterology commissioning guide
See this guidance in practice
The summary of the key recommendations in the guidance written for patients, carers and those with little medical knowledge and may be used in local patient information leaflets.
Quick Reference Guide
The quick reference guide presents recommendations for health professionals
The published NICE clinical guidance, contains the recommendations for health professionals and NHS bodies.
The published full clinical guidance for specialists with background, evidence, recommendations and methods used.