NICE-CADTH scientific advice

Developers of medicinal products can seek parallel scientific advice from NICE and the Canadian Agency for Drugs and Technology in Health (CADTH).

You can get advice from both agencies, at the same time, about planned evidence generation. This might include:

  • proposed clinical trials
  • health economic modelling
  • evidence synthesis
  • patient preference studies
  • post-licensing evidence generation.

You can ask questions to NICE and CADTH individually or jointly.

Once the project timeline has been provisionally agreed, we will share the latest version of the briefing book template and supporting guidance to help you in your preparations.

Make an enquiry

The process

If you think you have left it too late to seek advice, contact us. We may still be able to help.

  • First contact

    You contact us to discuss your requirements. You answer a series of preliminary questions about your product. We contact CADTH and agree a timeline between the 3 parties.

  • You sign and return the contract

    This must happen before the agreed submission date for the draft briefing book.

    NICE and CADTH have separate fees and separate contracts with the developer.

  • Send us your draft briefing book

    This is the key document that the project is centred around. A briefing book template for pharmaceutical companies is available for you to use. Guidance notes are also available.

  • We send you a quote

    Based on the content of your draft briefing book, we send you an initial quote for the project. You then have an opportunity to make any changes to your briefing book before submitting the final version.

    CADTH will send its quote separately to the developer.

  • wk1

    Submit your final briefing book

  • We confirm the project fee

    Once we've reviewed the final briefing book, we confirm the fee. This may differ from the initial quote, if any changes were made.

  • We send you an updated contract

    We update the contract with the confirmed project fee and send you a copy for your records.

  • wk6

    We may ask some clarification questions about your product development plans

    Having identified and spoken to our panel of experts and CADTH, we may ask you to clarify or provide further information on certain details in your briefing book.

    You'll have approximately 2 weeks to respond.

  • wk10

    We hold a meeting with you, CADTH and a panel of experts from Canada and the UK

    This will be a 4-hour physical or virtual meeting. It will be an open discussion to explore the issues we have identified in your briefing book. This helps us to prepare our answers for the final advice report.

  • wk20

    We send our advice reports

    The final advice reports from NICE and CADTH are combined into one report. This includes a joint summary agreed by both agencies.

    Please allow a further 2 weeks for this if your project is classified as large.

Clarification stage (optional)

  • +3wks

    You can send us any clarification questions you have about the report

    These questions are to clarify the meaning of the advice and cannot be requests for new information.

    Further advice can be arranged for an additional fee. Please contact us to discuss any requirements.

  • +6wks

    We respond to your clarification questions, in writing