Preliminary Independent Model Advice (PRIMA)

We provide expert independent advice to improve the quality of health economics models.

PRIMA is a comprehensive peer review service. It's designed for developers of pharmaceuticals, medical devices, diagnostics and public health interventions. It ensures the quality of your model structure, computation, coding, usability and transparency.

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What do we offer?

Standard service

This service offers:

  • Expert input into the clinical validity of the modelled treatment and disease pathway.
  • Advice on the face validity of the model’s assumptions and structure.
  • Identification of computational and coding errors.
  • Verification of consistency between the technical report and the model parameters and outputs.
  • Advice on improving the transparency and usability of the model.
  • Optional clarification stage.

We produce reports in 12 weeks.

Express service

This service offers:

  • Identification of computational and coding errors.
  • Verification of consistency between the technical report and the model parameters and outputs.
  • Advice on improving the transparency and usability of the model.
  • Optional clarification stage.

We produce reports in 8 weeks.

Both services provide:

  • A report detailing the findings and recommendations.
  • A technical review checklist explaining the methods used to evaluate the model and technical report.
  • The economic model after any corrections have been made.

What information will we need?

You'll have to send an executable model and a technical report.

The technical report should include:

  • a brief overview of the disease and treatment pathway
  • a description of the model's structure, assumptions and parameters, including sources
  • an overview of how to use the model, including assumptions for sensitivity analyses:

Packages

You can request a combined package with PRIMA and our standard scientific advice or express scientific advice service. Ask specific questions about your clinical evidence, evidence synthesis, and economic modelling plans. Submit your model for evaluation. The results help you generate relevant evidence and modelling to show your product’s value.

Get in touch to discuss a package that meets your needs.

The Takeda team highly regarded the quality of the PRIMA reports and model review documentation. We appreciated the PRIMA team’s engaging and flexible approach at this pivotal stage in development and look forward to using the service as part of our model development efforts going forward.
Peter Wheatley-Price, Market Access and Pricing Director at Takeda UK Ltd