In development: Guidance, quality standards and advice

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Guidance, NICE advice and quality standards in development
Title	Type	Expected publication date
Setmelanotide for treating obesity and hyperphagia in Bardet-Biedl syndrome (review of HST31) [ID6598]	Highly specialised technology	19 August 2026
Severe and enduring mental illness guidance review	NICE guideline	TBC
Sipavibart for preventing COVID 19 [ID6282]	Technology appraisal guidance	TBC
Sirolimus gel for treating facial angiofibroma from tuberous sclerosis complex in people 6 years and older (review of TA972) [ID6440]	Technology appraisal guidance	TBC
Sirolimus-eluting collagen implant for creating vascular access for haemodialysis in end-stage kidney disease [TSID9147]	Technology appraisal guidance	TBC
Sodium zirconium cyclosilicate for treating hyperkalaemia (partial review of TA599) [ID6439]	Technology appraisal guidance	TBC
Software for electroencephalogram (EEG) interpretation to support diagnosing epilepsy	Health technology evaluation	15 September 2026
Sonrotoclax for treating relapsed or refractory mantle cell lymphoma after an anti-CD20 treatment and a BTK inhibitor [ID6654]	Technology appraisal guidance	TBC
Sotatercept for treating pulmonary arterial hypertension [ID6163]	Technology appraisal guidance	TBC
Soticlestat for treating seizures associated with Dravet syndrome in people 2 years and over [TSID12091]	Technology appraisal guidance	TBC
Soticlestat for treating seizures associated with Lennox–Gastaut syndrome in people 2 years and over [TSID10632]	Technology appraisal guidance	TBC
Sotorasib for previously treated KRAS G12C mutation-positive advanced non-small-cell lung cancer (MA review of TA781) [ID6287]	Technology appraisal guidance	TBC
SpaceOAR hydrogel spacer for reducing rectal toxicity during radiotherapy for prostate cancer (Suspended – referred to technology appraisals)	Medical technologies guidance	TBC
Spartalizumab with dabrafenib and trametinib for untreated BRAF V600 mutation-positive unresectable or metastatic melanoma [ID1668]	Technology appraisal guidance	21 April 2021
Spesolimab for preventing generalised pustular psoriasis flares in people 12 years and over [TSID12086]	Technology appraisal guidance	TBC
Subcutaneous spesolimab 1 ml formulation for preventing generalised pustular psoriasis flares in people 12 years and over [ID6216]	Technology appraisal guidance	TBC
Sugemalimab with chemotherapy for untreated metastatic non-small-cell lung cancer [ID4001]	Technology appraisal guidance	TBC
Surgical mesh for treatment of non-primary ventral hernias	HealthTech guidance	TBC
Surgical mesh for treatment of primary ventral hernias	Health technology evaluation	3 February 2027
Surgical vessel sealing systems (MT798)	Medical technologies guidance	TBC
Suspected Cancer: recognition and referral (update)	NICE guideline	15 April 2026
Suspected sepsis in pregnancy: recognition, diagnosis and early management	NICE guideline	17 February 2027
Suspected sepsis in under 16s: recognition, diagnosis and early management	NICE guideline	17 February 2027
Suspected sepsis: recognition, diagnosis and early management	NICE guideline	TBC
Suspected sepsis: recognition, diagnosis and early management - procalcitonin testing	NICE guideline	15 July 2026

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