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Highly specialised technologies guidance (7)
Interventional procedures guidance (2)
Technology appraisal guidance (208)
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Guidance, NICE advice and quality standards in development
Title
Type
Expected publication date
Pembrolizumab with chemotherapy then olaparib maintenance for
treating
BRCA-negative advanced epithelial ovarian, fallopian tube or peritoneal cancer [ID3853]
Technology appraisal guidance
TBC
Pembrolizumab with chemotherapy with or without bevacizumab for
treating
platinum-resistant recurrent ovarian cancer after 1 or 2 treatments ID6363
Technology appraisal guidance
TBC
Pembrolizumab with ipilimumab for
treating
PD-L1-positive advanced non-small-cell lung cancer [ID3861]
Technology appraisal guidance
TBC
Pembrolizumab with olaparib for
treating
hormone-relapsed metastatic prostate cancer after abiraterone or enzalutamide and chemotherapy [ID3814]
Technology appraisal guidance
TBC
Pembrolizumab with stereotactic body radiotherapy for
treating
unresected stage 1 or 2 non-small-cell lung cancer [ID6149]
Technology appraisal guidance
TBC
Pertuzumab–trastuzumab with chemotherapy for
treating
HER2-positive breast cancer [ID2724]
Technology appraisal guidance
TBC
Pirtobrutinib for
treating
chronic lymphocytic leukaemia or small lymphocytic lymphoma after 1 or more BTK inhibitors [ID6269]
Technology appraisal guidance
29 January 2026
Pirtobrutinib for
treating
relapsed or refractory mantle cell lymphoma [ID3975]
Technology appraisal guidance
TBC
Plozasiran for
treating
familial chylomicronaemia syndrome [ID6593]
Technology appraisal guidance
18 November 2026
Polihexanide eye drops for
treating
acanthamoeba keratitis in people 12 years and over [ID6497]
Technology appraisal guidance
18 March 2026
Radium-223 dichloride with enzalutamide for
treating
asymptomatic or mildly symptomatic hormone-relapsed metastatic prostate cancer with bone metastases [ID6512]
Technology appraisal guidance
7 April 2027
Regorafenib for
treating
advanced gastrointestinal stromal tumours [ID1056]
Technology appraisal guidance
15 November 2017
Remibrutinib for
treating
chronic spontaneous urticaria inadequately controlled by H1-antihistamines ID6356
Technology appraisal guidance
8 July 2026
Repotrectinib for
treating
NTRK fusion-positive advanced solid tumours in people 12 years and over [TSID12147]
Technology appraisal guidance
TBC
Repotrectinib for
treating
ROS1-positive advanced non-small-cell lung cancer [ID6277]
Technology appraisal guidance
TBC
Resmetirom for
treating
non-alcoholic steatohepatitis and liver fibrosis [ID6529]
Technology appraisal guidance
10 June 2026
Retifanlimab with platinum-based chemotherapy for
treating
inoperable, locally recurrent or metastatic squamous cell anal canal cancer untreated with systemic chemotherapy ID6482 [ID6482]
Technology appraisal guidance
TBC
Rilzabrutinib for
treating
persistent or chronic immune thrombocytopenia in people aged 12 and over [ID6395]
Technology appraisal guidance
TBC
Rivogenlecleucel for
treating
haematological cancers in children and young people undergoing haploidentical haematopoietic stem cell transplant [ID1601]
Technology appraisal guidance
TBC
Rivogenlecleucel for
treating
haematological non-malignant diseases in children and young people undergoing haploidentical haematopoietic stem cell transplant [ID1496]
Technology appraisal guidance
TBC
Rocatinlimab for
treating
moderate to severe atopic dermatitis in people 12 years and over [ID6565]
Technology appraisal guidance
TBC
Ropeginterferon alfa-2b for
treating
polycythaemia vera without symptomatic splenomegaly [ID1596]
Technology appraisal guidance
TBC
Rozanolixizumab for
treating
antibody-positive generalised myasthenia gravis [ID5092]
Technology appraisal guidance
TBC
Ruxolitinib for
treating
moderate to severe chronic graft-versus-host disease after an allogeneic stem cell transplant in people 28 days to 17 years [ID6427]
Technology appraisal guidance
TBC
Sacituzumab govitecan for
treating
advanced non-small-cell lung cancer after platinum-based chemotherapy and a PD-1 or PD-L1 inhibitor [ID6375]
Technology appraisal guidance
TBC
Sasanlimab with BCG for
treating
high-risk non-muscle-invasive bladder cancer untreated with BCG ID6454
Technology appraisal guidance
TBC
Sebetralstat for
treating
acute attacks of hereditary angioedema in people aged 12 and over [ID6284]
Technology appraisal guidance
TBC
Secukinumab for
treating
enthesitis-related arthritis or juvenile psoriatic arthritis [ID3738]
Technology appraisal guidance
TBC
Selpercatinib for
treating
RET fusion-positive advanced solid tumours in people aged 12 and over with no other treatment options [ID6273]
Technology appraisal guidance
TBC
Selumetinib for
treating
symptomatic and inoperable plexiform neurofibromas associated with neurofibromatosis type 1 [ID6385]
Technology appraisal guidance
TBC
Semaglutide for
treating
moderate to advanced liver fibrosis (without cirrhosis) caused by metabolic dysfunction-associated steatohepatitis [ID6458]
Technology appraisal guidance
12 August 2026
Setmelanotide for
treating
acquired hypothalamic obesity in people 4 years and over ID6542
Technology appraisal guidance
10 February 2027
Setmelanotide for
treating
obesity and hyperphagia in Bardet-Biedl syndrome (review of HST31) [ID6598]
Highly specialised technology
19 August 2026
Sirolimus gel for
treating
facial angiofibroma from tuberous sclerosis complex in people 6 years and older (review of TA972) [ID6440]
Technology appraisal guidance
TBC
Sodium zirconium cyclosilicate for
treating
hyperkalaemia (partial review of TA599) [ID6439]
Technology appraisal guidance
11 March 2026
Sonrotoclax for
treating
relapsed or refractory mantle cell lymphoma after an anti-CD20 treatment and a BTK inhibitor [ID6654]
Technology appraisal guidance
TBC
Sotatercept for
treating
pulmonary arterial hypertension [ID6163]
Technology appraisal guidance
TBC
Soticlestat for
treating
seizures associated with Dravet syndrome in people 2 years and over TSID 12091
Technology appraisal guidance
TBC
Soticlestat for
treating
seizures associated with Lennox–Gastaut syndrome in people 2 years and over TSID 10632
Technology appraisal guidance
TBC
Tafasitamab with lenalidomide and rituximab for
treating
relapsed or refractory follicular lymphoma after 1 or more systemic treatments ID6413
Technology appraisal guidance
15 July 2026
Targeted-release budesonide for
treating
primary IgA nephropathy (review of TA937) [ID6485]
Technology appraisal guidance
11 February 2026
Tarlatamamb for
treating
extensive stage small-cell lung cancer that has progressed after platinum-based chemotherapy [ID6617]
Technology appraisal guidance
TBC
Teclistamab with daratumumab for
treating
relapsed or refractory multiple myeloma after 1 or more therapies [ID6201]
Technology appraisal guidance
28 July 2027
Telisotuzumab vedotin for
treating
c-MET overexpressed, EGFR wild-type, non-squamous advanced non-small-cell lung cancer after 1 or more systemic treatments [ID6253]
Technology appraisal guidance
TBC
Teprotumumab for
treating
thyroid eye disease [ID6432]
Technology appraisal guidance
TBC
Tezepelumab for
treating
severe chronic rhinosinusitis with nasal polyps ID6379
Technology appraisal guidance
9 September 2026
Tiragolumab with atezolizumab for
treating
advanced oesophageal squamous cell cancer after chemoradiotherapy [ID6267]
Technology appraisal guidance
TBC
Tiragolumab with atezolizumab for
treating
locally advanced unresectable stage 3 non-small-cell lung cancer after at least 2 cycles of platinum-based chemoradiation [ID6250]
Technology appraisal guidance
TBC
Tisotumab vedotin for
treating
recurrent or metastatic cervical cancer that has progressed on or after systemic treatment [ID3753]
Technology appraisal guidance
12 June 2026
Tofersen for
treating
amyotrophic lateral sclerosis caused by SOD1 gene mutations [ID3767]
Highly specialised technology
TBC
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