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Area of interest

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Guidance programme

Advice programme

Showing 5956 to 5970 of 8213 results

  1. Neuropathic pain relief:- Does early treatment with a centrally acting analgesic (for example pregabalin) reduce the frequency or severity of neuropathic pain in people with spinal cord injury?

    Recommendation ID NG41/1 Question Neuropathic pain relief:- Does early treatment with a centrally acting analgesic (for example pregabalin)

    Research recommendation
    Published
    4 April 2016

  2. Newly diagnosed seizures (focal and generalised) – monotherapy: How do the newer AEDs compare in efficacy to the standard AEDs in the treatment of newly diagnosed epilepsy? Focal seizures: carbamazepine, eslicarbazepine acetate, lacosamide, lamotrigine, levetiracetam, pregabalin  and zonisamide. Generalised seizures: lamotrigine, levetiracetam, sodium valproate and zonisamide.

    Recommendation ID CG137/1 Question Newly diagnosed seizures (focal and generalised) – monotherapy: How do the newer AEDs compare in efficacy

    Research recommendation
    Published
    13 August 2021

  3. NICE agreed that further research was needed because there is currently no clinical- or cost-effectiveness evidence evaluating the use of Holoclar in both eyes in bilateral patients. The committee was aware of the ongoing HOLOCORE trial which is recruiting both unilateral and bilateral patients, but only evaluates the success of a second transplant in 1 eye rather than transplant success in both eyes.

    Recommendation ID TA467/1 Question NICE agreed that further research was needed because there is currently no clinical- or cost-effectiveness

    Research recommendation
    Published
    15 October 2018

  4. NICE agreed that further research would be of value to investigate factors which can predict the likelihood of rapid progression of disease and response to treatment with biological DMARDs. Factors to investigate include:- persistent elevation of inflammatory markers (such as C-reactive protein [CRP]) and- presence of erosions on X-ray and- positive for anti-citrullinated protein antibodies (ACPA).

    Recommendation ID TA375/1 Question NICE agreed that further research would be of value to investigate factors which can predict the likelihood

    Research recommendation
    Published
    15 March 2016

  5. What are the long-term risks of mesh surgery compared with non-mesh surgery for stress urinary incontinence and pelvic organ prolapse in women?

    Recommendation ID NG123/5 Question What are the long-term risks of mesh surgery compared with non-mesh surgery for stress urinary incontinence

    Research recommendation
    Published
    21 June 2019

  6. Long-term safety of ovarian stimulation and ovulation induction for women:- Is there an association between ovulation induction or ovarian stimulation and adverse long-term (over 20 years) effects in women in the UK?

    Recommendation ID CG156/4 Question Long-term safety of ovarian stimulation and ovulation induction for women:- Is there an association

    Research recommendation
    Published
    9 June 2015

  7. Long-term safety of tenofovir disoproxil in chronic hepatitis B:- Further research should be undertaken to determine the long-term safety of tenofovir disoproxil, including the risk of clinically significant hypophosphataemia and related bone toxicity, in people with chronic hepatitis B. The cost effectiveness of routine monitoring for phosphate loss and bone disease in people with chronic hepatitis B who are receiving tenofovir disoproxil treatment needs further evaluation.

    Recommendation ID CG165/3 Question Long-term safety of tenofovir disoproxil in chronic hepatitis B:- Further research should be undertaken

    Research recommendation
    Published
    9 June 2015

  8. Magnesium sulfate for neuroprotection: bolus plus infusion compared with bolus alone:- What is the clinical effectiveness of a bolus plus infusion of magnesium sulfate compared with a bolus alone for preventing neurodevelopmental injury in babies born preterm?

    Recommendation ID NG25/4 Question Magnesium sulfate for neuroprotection: bolus plus infusion compared with bolus alone:- What is the clinical

    Research recommendation
    Published
    11 December 2015

  9. Maintaining benefits after successful treatment of anorexia nervosa:- What factors (including comorbidities, personal, social and demographic factors, treatment type,and subsequent relapse prevention interventions) are associated with continued benefit after successful treatment for anorexia nervosa?

    Recommendation ID NG69/5 Question Maintaining benefits after successful treatment of anorexia nervosa:- What factors (including comorbidities

    Research recommendation
    Published
    12 October 2018

  10. Maintaining the benefits of early intervention in psychosis services after discharge:- How can the benefits of early intervention in psychosis services be maintained once service users are discharged after 3 years?

    Recommendation ID CG178/4 Question Maintaining the benefits of early intervention in psychosis services after discharge:- How can the benefits

    Research recommendation
    Published
    9 June 2015

  11. Maintenance treatment:- In the maintenance treatment of bipolar disorder, what is the relative effect on quality of life of lithium, an antipsychotic (haloperidol, olanzapine, quetiapine or risperidone), or a combination of lithium and an antipsychotic?

    Recommendation ID CG185/2 Question Maintenance treatment:- In the maintenance treatment of bipolar disorder, what is the relative effect

    Research recommendation
    Published
    9 June 2015

  12. What is the best and most cost-effective management strategy for people whose first surgery for primary hyperparathyroidism is not successful?

    Recommendation ID NG132/2 Question What is the best and most cost-effective management strategy for people whose first surgery for primary

    Research recommendation
    Published
    25 October 2019

  13. What is the effectiveness and safety of sacral nerve stimulation and transanal irrigation compared to symptomatic treatment for people with major low anterior resection syndrome?

    Recommendation ID NG151/2 Question What is the effectiveness and safety of sacral nerve stimulation and transanal irrigation compared to

    Research recommendation
    Published
    10 February 2020

  14. For people with different causes of shoulder pain after stroke, what is the clinical and cost effectiveness of interventions in reducing pain?

    Recommendation ID NG236/5 Question For people with different causes of shoulder pain after stroke, what is the clinical and cost effectiveness

    Research recommendation
    Published
    11 January 2024

  15. Management of smouldering myeloma:- Which combinations of FISH, molecular technologies, bone marrow plasma cell percentage, whole-body imaging, immunophenotype, serum-free light-chain levels or ratio, Hevylite, paraprotein levels, immunoparesis, and International Staging System (ISS) are most effective at risk stratification for people with smouldering myeloma? What is the comparative effectiveness of fixed duration treatment (with or without bone-directed therapy), continuous treatment (with or without bone-directed therapy) and no treatment (with or without bone-directed therapy) for people with smouldering myeloma?

    Recommendation ID NG35/3 Question Management of smouldering myeloma:- Which combinations of FISH, molecular technologies, bone marrow plasma

    Research recommendation
    Published
    5 April 2016