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Guidance programme

Advice programme

Showing 5351 to 5400 of 8238 results

  1. What is the cost effectiveness and safety of non-surgical ablation and stereotactic body radiotherapy compared to resection for people with metastatic colorectal cancer in the lung amenable to local treatment?

    Recommendation ID NG151/1 Question What is the cost effectiveness and safety of non-surgical ablation and stereotactic body radiotherapy

  2. Treatment for people with an IOP of 22 or 23 mmHg:- What is the clinical and cost effectiveness of treating an intraocular pressure (IOP) of 22 or 23 mmHg in people with normal optic discs and visual fields?

    Recommendation ID NG81/6 Question Treatment for people with an IOP of 22 or 23 mmHg:- What is the clinical and cost effectiveness of treating

  3. For people with active, drug susceptible TB who experience treatment interruptions because of adverse events, particularly hepatotoxicity, what approach to re-establishing treatment is mosteffective in reducing mortality and morbidity?

    Recommendation ID NG33/5 Question For people with active, drug susceptible TB who experience treatment interruptions because of adverse

  4. Treatment of convulsive status epilepticus (that is, not just refractory): What is the most effective and safest AED to treat: established (usually lasting longer than 30 minutes) convulsive status epilepticus refractory convulsive status epilepticus?

    Recommendation ID CG137/4 Question Treatment of convulsive status epilepticus (that is, not just refractory): What is the most effective

  5. Framing content in vaccination invitations: What is the relative effectiveness and acceptability of different styles of phrasing content in a vaccination invitation in the UK?

    Recommendation ID NG218/05 Question Framing content in vaccination invitations: What is the relative effectiveness and acceptability of

  6. What is the relative effectiveness of sertraline compared with cognitive behavioural therapy (CBT) in people with generalised anxiety disorder (GAD) that has not responded to guided self-help and psychoeducation in a stepped-care model?

    Recommendation ID CG113/1 Question What is the relative effectiveness of sertraline compared with cognitive behavioural therapy (CBT) in

  7. Risk factors for and clinical indicators of early-onset infection: What is the risk of early-onset neonatal infection with maternal obesity and how does this change with increasing body mass index?

    Recommendation ID NG195/2 Question Risk factors for and clinical indicators of early-onset infection: What is the risk of early-onset neonatal

  8. What is the role of arm and shoulder specific exercises compared with and/or used as an adjunct to established lymphoedema treatments (such as compression garments and complex decongestive therapy)?

    Recommendation ID CG81.1/1 Question What is the role of arm and shoulder specific exercises compared with and/or used as an adjunct to

  9. Intersecting social, cultural and personal factors: What is the role of intersecting social, cultural and personal factors in developing poor social, emotional and mental wellbeing?

    Recommendation ID NG223/02 Question Intersecting social, cultural and personal factors: What is the role of intersecting social, cultural

  10. What is the safety and efficacy of botulinum toxin compared with (a) usual care, (b) antimuscarinics and (c) augmentation cystoplasty in people with primary cerebral conditions with lower urinary tract dysfunction?

    Recommendation ID CG148/5 Question What is the safety and efficacy of botulinum toxin compared with (a) usual care, (b) antimuscarinics

  11. Safety and efficacy of carotid stenting: What is the safety and efficacy of carotid stenting compared with carotid endarterectomy when these procedures are carried out within 2 weeks of TIA or recovered stroke?

    Recommendation ID NG128/08 Question Safety and efficacy of carotid stenting: What is the safety and efficacy of carotid stenting compared

  12. Ketogenic diets: What is the short-term and long-term clinical and cost effectiveness of ketogenic diets in adults and children with drug-resistant epilepsy, and what factors affect the long-term maintenance and tolerability of ketogenic diets?

    Recommendation ID NG217/10 Question Ketogenic diets: What is the short-term and long-term clinical and cost effectiveness of ketogenic

  13. Indicator conditions:- What is the UK prevalence of HIV in various indicator conditions, and how effective are interventions using indicator condition-targeted testing compared with other testing strategies?

    Recommendation ID NG60/4 Question Indicator conditions:- What is the UK prevalence of HIV in various indicator conditions, and how effective

  14. Frequency and duration of endoscopic surveillance: What is the usefulness of clinical and molecular biomarkers to inform the optimal frequency and duration of endoscopic surveillance for adults with Barrett's oesophagus?

    Recommendation ID NG231/02 Question Frequency and duration of endoscopic surveillance: What is the usefulness of clinical and molecular

  15. Risk stratification tool to estimate risk of recurrence: What is the utility of a risk stratification tool to estimate the risk of subsequent aneurysmal subarachnoid haemorrhage?

    Recommendation ID NG228/05 Question Risk stratification tool to estimate risk of recurrence: What is the utility of a risk stratification

  16. Carbon monoxide monitoring: What is the validity of different thresholds of carbon monoxide in exhaled breath as markers of quitting, based on diagnostic review and modelling?

    Recommendation ID NG209/13 Question Carbon monoxide monitoring: What is the validity of different thresholds of carbon monoxide in exhaled

  17. What is the value of a key worker approach (defined by protocol and delivered in addition to usual care) for autistic children and young people in terms of parental satisfaction, functioning and stress and child psychopathology?

    Recommendation ID CG170/1 Question What is the value of a key worker approach (defined by protocol and delivered in addition to usual care)

  18. What key factors influence differences in walking and cycling behaviour among different groups – and what are the implications for interventions aiming to achieve population-level change and reduce inequalities?

    Recommendation ID PH41/5 Question What key factors influence differences in walking and cycling behaviour among different groups – and

  19. What key factors influence the effectiveness of population-level or whole-area approaches to encouraging walking or cycling? How do these factors interact?

    Recommendation ID PH41/2 Question What key factors influence the effectiveness of population-level or whole-area approaches to encouraging

  20. Incentives for school-aged vaccinations: What levels and types of incentives are effective and acceptable for increasing vaccination uptake in a school-aged population in the UK?

    Recommendation ID NG218/11 Question Incentives for school-aged vaccinations: What levels and types of incentives are effective and acceptable

  21. Lifestyle factors to reduce the risk of pelvic floor dysfunction: What lifestyle factors reduce the risk of developing pelvic floor dysfunction (diet, reducing carbonated drink and caffeine intake)?

    Recommendation ID NG210/04 Question Lifestyle factors to reduce the risk of pelvic floor dysfunction: What lifestyle factors reduce the

  22. What measures would make up an effective, standardised approach to evaluation of condom distribution schemes?: How can we develop a standardised framework to evaluate condom schemes and what would be included in that evaluation?

    Recommendation ID NG68/1 Question What measures would make up an effective, standardised approach to evaluation of condom distribution

  23. What methods are most effective for assessing and diagnosing the presence and severity of alcohol misuse in children and young people?

    Recommendation ID CG115/2 Question What methods are most effective for assessing and diagnosing the presence and severity of alcohol misuse

  24. What methods can improve the identification of women at high risk of postpartum psychosis and reduce this risk?

    Recommendation ID CG192/1 Question What methods can improve the identification of women at high risk of postpartum psychosis and reduce

  25. Community-based models of flu vaccination:- What models of community-based flu vaccination provision (for example, community pharmacies, community nursing and midwifery teams and outreach services) are effective and cost-effective for increasing uptake in eligible groups?

    Recommendation ID NG103/5 Question Community-based models of flu vaccination:- What models of community-based flu vaccination provision

  26. What models of cross-organisational working improve clinical and cost effectiveness in relation to the suboptimal prescribing of medicines – for example, between NHS and social care, or primary and secondary care, or between NHS and commercial organisations?

    Recommendation ID NG5/4 Question What models of cross-organisational working improve clinical and cost effectiveness in relation to the

  27. Timing of pre-emptive transplant:- What is the most clinical and cost-effective strategy for timing of pre-emptive transplantation?

    Recommendation ID NG107/2 Question Timing of pre-emptive transplant:- What is the most clinical and cost-effective strategy for timing

  28. What is the improvement in the cost-effectiveness metrics for statin therapy in reducing CVD that can be obtained when using a complete individual patient-based outcomes meta-analysis data set compared with using published outcomes data?

    Recommendation ID CG181/2 Question What is the improvement in the cost-effectiveness metrics for statin therapy in reducing CVD that can

  29. Interventions: What is the most clinically and cost‑effective management strategy for adults with calcific mitral stenosis and an indication for intervention?

    Recommendation ID NG208/21 Question Interventions: What is the most clinically and cost‑effective management strategy for adults with calcific

  30. What is the incidence and prevalence of, and what are the demographic trends in, skin cancer in the UK? (Demographic variables might include whether someone is an outdoor or indoor worker, their skin type and socioeconomic status.)

    Recommendation ID PH32/1 Question What is the incidence and prevalence of, and what are the demographic trends in, skin cancer in the UK

  31. Antibiotics for suspected early-onset infection: What is the incidence and severity of adverse effects with antibiotics used to prevent or treat early-onset neonatal infection?

    Recommendation ID NG195/13 Question Antibiotics for suspected early-onset infection: What is the incidence and severity of adverse effects

  32. Interventions for tricuspid regurgitation: What is the most clinically and cost-effective management strategy for adults with tricuspid regurgitation?

    Recommendation ID NG208/02 Question Interventions for tricuspid regurgitation: What is the most clinically and cost-effective management

  33. Antibiotics for suspected early-onset infection: What is the incidence in England and Wales of resistance to commonly used antibiotics among bacteria that cause early-onset neonatal infection?

    Recommendation ID NG195/11 Question Antibiotics for suspected early-onset infection: What is the incidence in England and Wales of resistance

  34. Managing acute hydrocephalus: What is the most clinically and cost-effective method of cerebrospinal fluid drainage or diversion (for example shunt surgery, external ventricular drain surgery or lumbar drain) for symptomatic acute hydrocephalus?

    Recommendation ID NG228/07 Question Managing acute hydrocephalus: What is the most clinically and cost-effective method of cerebrospinal

  35. Long-term effectiveness of total hip replacement: What is the long-term clinical and cost effectiveness for adults (including different subgroups) undergoing total hip replacement compared with hemiarthroplasty for displaced intracapsular hip fracture?

    Recommendation ID CG124/06 Question Long-term effectiveness of total hip replacement: What is the long-term clinical and cost effectiveness

  36. Prophylactic antibiotics for preventing exacerbations: - What is the long-term clinical and cost effectiveness of prophylactic antibiotics for people with stable COPD who are at high risk of exacerbations?

    Recommendation ID NG115/7 Question Prophylactic antibiotics for preventing exacerbations: - What is the long-term clinical and cost effectiveness

  37. What is the most clinically and cost-effective pathway for diagnosing clinically significant prostate cancer?

    Recommendation ID NG131/4 Question What is the most clinically and cost-effective pathway for diagnosing clinically significant prostate

  38. Long-term effectiveness of selective laser trabeculoplasty: What is the long-term effectiveness and cost effectiveness of selective laser trabeculoplasty as a first-line treatment compared with intraocular pressure-lowering eye drops in ocular hypertension or COAG in adults?

    Recommendation ID NG81/2 Question Long-term effectiveness of selective laser trabeculoplasty: What is the long-term effectiveness and cost

  39. Non-steroidal anti-inflammatory drugs (NSAIDs) – route of administration:- What is the most clinically and cost effective route of administration for NSAIDs in the management of acute pain thought to be due to renal or ureteric stones?

    Recommendation ID NG118/5 Question Non-steroidal anti-inflammatory drugs (NSAIDs) – route of administration:- What is the most clinically

  40. Individual-level interventions: What is the long-term effectiveness and cost effectiveness of universal individual-level interventions on mental wellbeing in different types of organisations?

    Recommendation ID NG212/01 Question Individual-level interventions: What is the long-term effectiveness and cost effectiveness of universal

  41. Monitoring after an intervention: What is the most clinically and cost‑effective timing, nature and frequency of follow up for different types of valve interventions, including repair and replacement with tissue or mechanical valves?

    Recommendation ID NG208/04 Question Monitoring after an intervention: What is the most clinically and cost‑effective timing, nature and