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  1. Supervised exercise programmes for treating people with intermittent claudication:- What is the clinical and cost effectiveness of supervised exercise programmes compared with unsupervised exercise for treating people with intermittent claudication, taking into account the effects on long-term outcomes and continuing levels of exercise?

    effectiveness. A community-based randomised controlled trial is required to compare the long-term clinical and cost effectiveness of a...

    Research recommendation
    Published
    9 June 2015

  2. Pharmacological treatment: In people in hospital who have delirium, which is the most effective medication (atypical antipsychotics, typical antipsychotics or benzodiazepines) compared with placebo or each other for treating delirium?

    in each arm) should be conducted in people in hospital with delirium to compare atypical antipsychotics, typical antipsychotics, or...

    Research recommendation
    Published
    3 February 2023

  3. What are the components of a decision aid to support people referred for elective joint replacement in making decisions about their treatment (for example, the type of procedure, timing and implant choice)?

    variation in the decision aids used in the studies, it was not possible to compare them with each other. The committee were therefore...

    Research recommendation
    Published
    10 August 2020

  4. Education about the latent first stage of labour: Does enhanced education specifically about the latent first stage of labour increase the number of nulliparous women who wait until they are in established labour before attending the obstetric or midwifery unit (or calling the midwife to a home birth), compared with women who do not receive this education?

    (randomised controlled trial or prospective observational study) would be to compare 2 groups of women experiencing their first labour...

    Research recommendation
    Published
    6 January 2023

  5. Psychosocial interventions for people with more severe learning disabilities:- For people with more severe learning disabilities, what is the clinical and cost effectiveness of psychosocial interventions to treat mental health problems?

    interventions to this group.Randomised controlled trials should be carried out to compare the clinical and cost effectiveness of...

    Research recommendation
    Published
    17 October 2016

  6. Anticipatory prescribing:- What is the clinical and cost effectiveness of anticipatory prescribing for patients dying in their usual place of residence, on patient and carer reported symptoms at end of life?

    randomised controlled trial (randomised by GP practice) is proposed to compare interventions of anticipatory prescribing ('just in case'...

    Research recommendation
    Published
    27 January 2016

  7. Hand decontamination:- When clean running water is not available, what is the clinical and cost effectiveness of using wipes, gels, handrubs or other products to remove visible contamination?

    hands has not been determined. A randomised controlled trial is required to compare hand wipes (alcohol and antiseptic), hand gels and...

    Research recommendation
    Published
    9 June 2015

  8. Pharmacological prevention: In people in hospital who are at high risk of delirium, which medication (atypical antipsychotics, typical antipsychotics, benzodiazepines or acetylcholinesterase inhibitors), compared with placebo or each other, is more clinically and cost effective in preventing the development of delirium?

    be conducted in people in hospital who are at high risk of delirium to compare atypical antipsychotics, typical antipsychotics,...

    Research recommendation
    Published
    3 February 2023

  9. What is the comparative clinical and cost effectiveness of pharmacological and psychosocial interventions for anxiety disorders in autistic children and young people?

    have not been evaluated in this population. A parallel-arm RCT should compare pharmacological and psychosocial interventions with...

    Research recommendation
    Published
    10 August 2021

  10. Intensive rehabilitation therapies after hip fracture: What is the clinical and cost effectiveness of additional intensive physiotherapy and/or occupational therapy (for example, progressive resistance training) after hip fracture?

    be undertaken. Outcomes should be followed over a minimum of 1 year, and compare if possible, either the recovery curve for restoration...

    Research recommendation
    Published
    3 February 2023

  11. Vascular access devices: skin decontamination:- What is the clinical and cost effectiveness of 2% chlorhexidine in alcohol versus 0.5% chlorhexidine in alcohol versus 2% chlorhexidine aqueous solution versus 0.5% chlorhexidine aqueous solution for cleansing skin (before insertion of peripheral vascular access devices [VADs] and during dressing changes of all VADs) in reducing VAD-related bacteraemia and VAD site infections?

    solutions in the community. A randomised controlled trial is required to compare the clinical and cost effectiveness of the different...

    Research recommendation
    Published
    9 June 2015

  12. Modes of provision of support to healthcare professionals:- What would be the impact of dietetic telephone support to healthcare professionals to aid in the diagnosis and assessment of babies showing non-IgE-mediated food allergy symptoms in primary care and community settings?

    and skills. A community-based randomised controlled trial is needed to compare the standard written dietetic referral method with...

    Research recommendation
    Published
    9 June 2015

  13. Pembrolizumab for untreated metastatic or unresectable recurrent head and neck squamous cell carcinoma (TA661)

    Evidence-based recommendations on pembrolizumab (Keytruda) for untreated metastatic or unresectable recurrent head and neck squamous cell carcinoma (HNSCC) in adults whose tumours express PD L1 with a combined positive score (CPS) of 1 or more.

    Technology appraisal guidance
    Published
    25 November 2020
    View recommendations

    Sections for TA661

  14. Methods research areas

    NICE priority methodological research areas.

  15. Oesophago-gastric cancer: assessment and management in adults (NG83)

    This guideline covers assessing and managing oesophago-gastric cancer in adults, including radical and palliative treatment and nutritional support. It aims to reduce variation in practice through better organisation of care and support, and improve quality of life and survival by giving advice on the most suitable treatments depending on cancer type, stage and location.

    NICE guideline
    Last updated
    4 July 2023
    View recommendations

    Sections for NG83