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Guidance programme

Advice programme

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  1. Imaging of ankle fractures:- Is CT scanning in addition to initial plain film X-ray clinically effective and cost effective for planning surgical treatment of unstable/displaced ankle fractures compared with plain film X-ray alone?

    associated with additional cost if another operation is needed. It is important to know whether adding CT scanning to plain film X-ray...

    Research recommendation
    Published
    21 March 2016

  2. Ravulizumab for treating paroxysmal nocturnal haemoglobinuria (TA698)

    Evidence-based recommendations on ravulizumab (Ultomiris) for treating paroxysmal nocturnal haemoglobinuria in adults.

    Technology appraisal guidance
    Published
    19 May 2021
    View recommendations

    Sections for TA698

  3. Brolucizumab for treating wet age-related macular degeneration (TA672)

    Evidence-based recommendations on brolucizumab (Beovu) for treating wet age-related macular degeneration in adults.

    Technology appraisal guidance
    Published
    3 February 2021
    View recommendations

    Sections for TA672

  4. Intravenous fluid therapy in adults in hospital (QS66)

    This quality standard covers managing intravenous (IV) fluid therapy safely and effectively for adults in hospital. It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    14 August 2014
    View quality statements

    Sections for QS66

  5. Decision-making and mental capacity (NG108)

    This guideline covers decision-making in people 16 years and over who may lack capacity now or in the future. It aims to help health and social care practitioners support people to make their own decisions where they have the capacity to do so. It also helps practitioners to keep people who lack capacity at the centre of the decision-making process.

    NICE guideline
    Published
    3 October 2018
    View recommendations

    Sections for NG108

  6. Additional assessments:- Do additional assessments (for IQ, language ability and motor ability) improve accuracy in diagnosing autism among preschool children (younger than 5 years) compared with signs and symptoms alone?

    assessments of IQ, language and motor abilities. As a consequence we do not know whether such assessments aid more accurate diagnosis of...

    Research recommendation
    Published
    9 June 2015

  7. Adding a newer anti-anginal drug to a calcium channel blocker:- What is the clinical and cost effectiveness of adding a newer anti-anginal drug (nicorandil, ivabradine or ranolazine) to a calcium channel blocker for treating stable angina?

    Any explanatory notes(if applicable) Why this is important:- We do not know the long-term clinical and cost effectiveness of adding a...

    Research recommendation
    Published
    9 June 2015

  8. Effective components of integrated regional services for people with a learning disability and behaviour that challenges:- What are the effective components of an integrated regional service for people with a learning disability and behaviour that challenges across health and social care (including pooling budgetsand other resources)?What are the barriers and facilitators to pooling budgets and other resources across regions?

    been little evidence of this happening in practice.Research is needed to know what mechanisms enable or stop this practice from...

    Research recommendation
    Published
    15 November 2018

  9. Frequency of monitoring:- How frequently should children be measured to identify faltering growth?

    explanatory notes(if applicable) Why this is important:- It is important to know whether a particular frequency or schedule of...

    Research recommendation
    Published
    15 October 2018

  10. Models of supported living:- What is the effectiveness and cost effectiveness of models of shared, supported living, such as Shared Lives?What are the views and experiences of people sharing their home and people who live with themunder programmes such as Shared Lives?

    supported living are effective specifically for them. It would be useful to know what kinds of supported living are acceptable and...

    Research recommendation
    Published
    15 November 2018

  11. Communication:- What are the most clinically effective and cost-effective methods of addressing patient and carer concerns about strong opioids, including anticipating and managing adverse effects, and engaging patients in prescribing decisions?

    Any explanatory notes(if applicable) Why this is important:- We know from qualitative work that patients do not always understand how...

    Research recommendation
    Published
    9 June 2015

  12. Pembrolizumab plus chemotherapy with or without bevacizumab for persistent, recurrent or metastatic cervical cancer (TA939)

    Evidence-based recommendations on pembrolizumab (Keytruda) plus chemotherapy with or without bevacizumab for persistent, recurrent or metastatic cervical cancer in adults.

    Technology appraisal guidance
    Published
    13 December 2023
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    Sections for TA939

  13. Palbociclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapy (TA836)

    Evidence-based recommendations on palbociclib (Ibrance) with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapy.

    Technology appraisal guidance
    Published
    26 October 2022
    View recommendations

    Sections for TA836

  14. Avelumab for untreated metastatic Merkel cell carcinoma (TA691)

    Evidence-based recommendations on avelumab (Bavencio) for untreated metastatic Merkel cell carcinoma in adults.

    Technology appraisal guidance
    Published
    21 April 2021

    Sections for TA691

  15. Trabectedin for the treatment of advanced soft tissue sarcoma (TA185)

    Evidence-based recommendations on trabectedin (Yondelis) for treating advanced soft tissue sarcoma in adults.

    Technology appraisal guidance
    Last updated
    8 February 2021
    View recommendations

    Sections for TA185