Search results

Evidence-based recommendations on molnupiravir (Lagevrio) for treating mild to moderate COVID-19 in adults who have a positive SARS-CoV-2 test.

Result type

Technology appraisal guidance

Last updated

26 February 2026

This guideline sets out an antimicrobial prescribing strategy for managing Clostridioides difficile infection in adults, young people and children aged 72 hours and over in community and hospital settings. It aims to optimise antibiotic use and reduce antibiotic resistance. The recommendations do not cover diagnosis.

Result type

Antimicrobial prescribing guideline

Published

23 July 2021

Evidence-based recommendations on coil embolisation of unruptured intracranial aneurysms. This involves placing coils inside the aneurysm using a thin tube to make the blood clot so it is less likely to burst.

Result type

HealthTech guidance

Published

26 January 2005

Evidence-based recommendations on endovascular stent–graft placement in thoracic aortic aneurysms and dissections. This involves placing a stent covered in graft material inside the aorta under X-ray guidance.

Result type

HealthTech guidance

Published

22 June 2005

Evidence-based recommendations on subthalamotomy for Parkinson's disease. This involves putting very thin needles into the brain through small holes made in the skull.

Result type

HealthTech guidance

Published

23 June 2004

Evidence-based recommendations on partial left ventriculectomy. This involves reducing the size of a part of the heart so it can pump blood more efficiently.

Result type

HealthTech guidance

Published

25 February 2004

Evidence-based recommendations on laparoscopic deroofing of simple renal cysts. This involves draining the cyst and removing part of the cyst wall through small cuts in the abdomen (keyhole surgery).

Result type

HealthTech guidance

Published

25 July 2007

NICE has implemented new measures to evaluate the cost-effectiveness of medicines, following a policy change that aims to give patients improved access to treatments. This follows the government’s decision to increase the thresholds that NICE can use in technology appraisals to £25,000 to £35,000 per quality-adjusted life year gained.

Evidence-based recommendations on transcervical ultrasound-guided radiofrequency ablation for symptomatic uterine fibroids in adults. This involves inserting a device through the cervix into the womb to destroy the fibroid using radiofrequency energy.

Result type

HealthTech guidance

Published

31 March 2021

This guideline has been updated and replaced by NICE guideline NG146.

Result type

Withdrawn guideline

Evidence-based recommendations on glycoprotein IIb/IIIa inhibitors (abciximab, eptifibatide, tirofiban) for treating acute coronary syndromes in adults.

Result type

Technology appraisal guidance

Last updated

1 March 2010

Evidence-based recommendations on pembrolizumab (Keytruda) for the adjuvant treatment of resected non-small-cell lung cancer in adults.

Result type

Technology appraisal guidance

Published

5 February 2025

This guideline covers helping adults and young people over 16 who are dependent on opioids to stop using drugs. It aims to reduce illicit drug use and improve people’s physical and mental health, relationships and employment.

Result type

Clinical guideline

Published

25 July 2007

NICE has developed a medtech innovation briefing (MIB) on Smart One for measuring lung function .

Result type

Medtech innovation briefing

Published

9 February 2017

This quality standard covers the assessment, management and care provided for people aged 14 and over who have coexisting severe mental illness and substance misuse. It describes high-quality care in priority areas for improvement.

Result type

Quality standard

Published

20 August 2019

This guideline covers diagnosing and managing bladder cancer in people 18 and above referred from primary care with suspected bladder cancer, and those with newly diagnosed or recurrent bladder (urothelial carcinoma, adenocarcinoma, squamous-cell carcinoma or small-cell carcinoma) or urethral cancer.

Result type

NICE guideline

Published

25 February 2015

This guideline covers the recognition, diagnosis and early management of suspected sepsis in pregnant or recently pregnant people. It includes recommendations on recognition and early assessment, initial treatment, escalating care, finding and controlling the source of infection, early monitoring, information and support, and training and education.

Result type

NICE guideline

Published

19 November 2025

of people who are living with, through and beyond a melanoma diagnosis in terms of survivorship and their disease journey? Any...

Result type

Research recommendation

Published

4 August 2022

Evidence-based recommendations on baricitinib for treating moderate to severe atopic dermatitis in adults.

Result type

Technology appraisal guidance

Published

3 March 2021

Evidence-based recommendations on processed nerve allografts to repair peripheral nerve discontinuities. This involves using a specially treated nerve (an allograft) taken from a human donor after death to bridge the gap in the nerve.

Result type

HealthTech guidance

Published

22 November 2017

Evidence-based recommendations on transcutaneous stimulation of the cervical branch of the vagus nerve to treat cluster headache and migraine in adults. This involves using a small handheld device to stimulate a nerve in the neck.

Result type

HealthTech guidance

Published

23 March 2016

Evidence-based recommendations on radially emitting laser fibre treatment of an anal fistula in adults. This involves applying laser energy to the fistula.

Result type

HealthTech guidance

Published

13 March 2019

Evidence-based recommendations on transcutaneous neuromuscular electrical stimulation for oropharyngeal dysphagia in adults. This involves electrically stimulating nerves in the throat or neck, while the person swallows. The aim is to strengthen the muscles involved in swallowing.

Result type

HealthTech guidance

Published

19 December 2018

Evidence-based recommendations on transurethral laser ablation for recurrent non-muscle-invasive bladder cancer in adults. This involves using a laser inserted into the bladder to destroy the cancer cells.

Result type

HealthTech guidance

Published

24 July 2019

Evidence-based recommendations on reinforcement of a permanent stoma with a synthetic or biological mesh to prevent a parastomal hernia. This involves inserting a piece of mesh to strengthen the abdominal wall.

Result type

HealthTech guidance

Published

26 June 2019

Evidence-based recommendations on percutaneous insertion of a cystic duct stent after cholecystostomy for acute calculous cholecystitis. This involves inserting a tube called a stent into or across the cystic duct. The aim is to allow bile to flow through the tube, bypassing the blockage and preventing further obstruction.

Result type

HealthTech guidance

Published

9 March 2022

Evidence-based recommendations on intramedullary distraction for lower limb lengthening in children, young people and adults. This involves surgically inserting a metal lengthening device in the shorter leg.

Result type

HealthTech guidance

Published

2 March 2022

Evidence-based recommendations on lateral elbow resurfacing for arthritis. This involves inserting an implant into the 2 bones that form the joint at the outer part of the elbow, under general anaesthetic.

Result type

HealthTech guidance

Published

22 September 2021

Evidence-based recommendations on endovascular closure of patent ductus arteriosus. This involves placing a blocking device into the heart, which stays in place permanently and the body’s tissue grows around it.

Result type

HealthTech guidance

Published

27 October 2004

Evidence-based recommendations on focal therapy using high-intensity focused ultrasound for localised prostate cancer. This involves using high-intensity focused ultrasound to heat up and destroy only the areas of the prostate with cancer (focal therapy). The aim is to destroy the cancer while reducing damage to healthy prostate tissue.

Result type

HealthTech guidance

Published

5 April 2023

Evidence-based recommendations on percutaneous thoracic duct embolisation for persistent chyle leak. In this procedure, under general anaesthesia, ultrasound and X-rays are used to create an image of the thoracic duct and find the leak. Then, using a needle, a tube is inserted through the abdominal wall (percutaneous) and guided into the thoracic duct. Small metal coils and medical glue are inserted through the tube and used to plug the leak (embolisation). The aim is to stop the leak.

Result type

HealthTech guidance

Published

5 April 2023

Evidence-based recommendations on insertion of an annular disc implant at lumbar discectomy. This involves inserting an implant to close the hole that is left in a torn disc after any bulging material has been removed during surgery.

Result type

HealthTech guidance

Published

27 November 2014

Early value assessment (EVA) guidance on digital technologies for delivering multidisciplinary weight-management services.

Result type

HealthTech guidance

Last updated

6 March 2024

Evidence-based recommendations on selpercatinib (Retsevmo) for untreated RET fusion-positive advanced non-small-cell lung cancer in adults.

Result type

Technology appraisal guidance

Published

26 July 2023

Evidence-based recommendations on olaparib (Lynparza) with abiraterone for untreated hormone-relapsed metastatic prostate cancer in adults.

Result type

Technology appraisal guidance

Published

7 February 2024

Evidence-based recommendations on botulinum toxin type A (Botox) for preventing headaches in adults with chronic migraine.

Result type

Technology appraisal guidance

Published

27 June 2012

Evidence-based recommendations on cobimetinib (Cotellic) with vemurafenib (Zelboraf) for treating unresectable or metastatic melanoma in adults with a BRAF V600 mutation.

Result type

Technology appraisal guidance

Published

26 October 2016

NICE has developed a medtech innovation briefing (MIB) on AlignRT in breast cancer radiotherapy .

Result type

Medtech innovation briefing

Published

24 August 2018

This guideline covers how to increase the uptake of HIV testing in primary and secondary care, specialist sexual health services and the community. It describes how to plan and deliver services that are tailored to the local prevalence of HIV, promote awareness of HIV testing and increase opportunities to offer testing to people who may have undiagnosed HIV.

Result type

NICE guideline

Last updated

26 September 2025

Evidence-based recommendations on olaparib (Lynparza) for previously treated BRCA mutation-positive hormone-relapsed metastatic prostate cancer in adults.

Result type

Technology appraisal guidance

Published

10 May 2023

on quality of life. Both increased the risk of adverse events in the long-term. While there was no evidence of increased risk of adverse...

Result type

Research recommendation

Published

22 January 2021

on quality of life. Both increased the risk of adverse events in the long-term. While there was no evidence of increased risk of adverse...

Result type

Research recommendation

Published

26 October 2020

Evidence-based recommendations on carotid artery stent placement for symptomatic extracranial carotid stenosis. This involves using a metal mesh called a stent to widen the narrowed carotid artery.

Result type

HealthTech guidance

Published

27 April 2011

This guideline sets out an antimicrobial prescribing strategy for acute otitis media (ear infection). It aims to limit antibiotic use and reduce antimicrobial resistance. Acute otitis media can be caused by viruses or bacteria. It lasts for about a week, and most children get better in 3 days without antibiotics. Serious complications are rare.

Result type

Antimicrobial prescribing guideline

Last updated

11 March 2022

Evidence-based recommendations on human growth hormone (somatropin; Genotropin, Humatrope, Norditropin, NutropinAq, Omnitrope, Saizen, Zomacton) for treating growth failure in children.

Result type

Technology appraisal guidance

Published

26 May 2010

Evidence-based recommendations on pembrolizumab (Keytruda) with carboplatin and paclitaxel for adults with untreated metastatic squamous non-small-cell lung cancer.

Result type

Technology appraisal guidance

Published

9 February 2022

This quality standard covers neonatal respiratory support in hospital for babies born preterm (before 37 weeks of pregnancy). It describes high-quality care in priority areas for improvement.

Result type

Quality standard

Published

15 July 2020

This guideline covers the diagnosis and management of tension-type headache, migraine (including migraine with aura and menstrual-related migraine), cluster headache and medication overuse headache in young people (aged 12 years and older) and adults. It aims to improve the recognition and management of headaches, with more targeted treatment to improve the quality of life for people with headaches, and to reduce unnecessary investigations.

Result type

Clinical guideline

Last updated

3 June 2025

Evidence-based recommendations on ocrelizumab (Ocrevus) for treating primary progressive multiple sclerosis in adults.

Result type

Technology appraisal guidance

Published

12 June 2019

NICE has developed a medtech innovation briefing (MIB) on contrast-enhanced spectral mammography for breast cancer .

Result type

Medtech innovation briefing

Published

30 August 2022