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  1. Removal, preservation and reimplantation of ovarian tissue for restoring fertility after gonadotoxic treatment (IPG772)

    Evidence-based recommendations on removal, preservation and reimplantation of ovarian tissue for restoring fertility after gonadotoxic treatment. This involves surgically removing ovarian tissue before a treatment for cancer or other medical condition that can damage the ovaries (gonadotoxic treatment) begins. The ovarian tissue is then frozen to be reimplanted after the gonadotoxic treatment is finished, to restore fertility.

    Interventional procedures guidance
    Published
    21 September 2023
    View recommendations

    Sections for IPG772

  2. Totally endoscopic robotically assisted coronary artery bypass grafting (IPG128)

    Evidence-based recommendations on totally endoscopic robotically assisted coronary artery bypass grafting (TECAB). This involves using small, remote-controlled robotic arms to carry out the grafting procedure.

    Interventional procedures guidance
    Published
    22 June 2005
    View recommendations

    Sections for IPG128

  3. Brachytherapy as the sole method of adjuvant radiotherapy for breast cancer after local excision (IPG268)

    Evidence-based recommendations on brachytherapy as the sole method of adjuvant radiotherapy for breast cancer after local excision. This involves inserting radioactive sources into the space in the breast where tissue has been removed to minimise the chances of the cancer coming back.

    Interventional procedures guidance
    Published
    23 July 2008
    View recommendations

    Sections for IPG268

  4. Prosthetic intervertebral disc replacement in the lumbar spine (IPG306)

    Evidence-based recommendations on prosthetic intervertebral disc replacement in the lumbar spine. This involves removing the damaged disc and inserting an artificial disc in its place.

    Interventional procedures guidance
    Published
    22 July 2009
    View recommendations

    Sections for IPG306

  5. Intramedullary distraction for lower limb lengthening (IPG718)

    Evidence-based recommendations on intramedullary distraction for lower limb lengthening in children, young people and adults. This involves surgically inserting a metal lengthening device in the shorter leg.

    Interventional procedures guidance
    Published
    2 March 2022
    View recommendations

    Sections for IPG718

  6. Cytoreduction surgery with hyperthermic intraoperative peritoneal chemotherapy for peritoneal carcinomatosis (IPG688)

    Evidence-based recommendations on cytoreduction surgery with hyperthermic intraoperative peritoneal chemotherapy for peritoneal carcinomatosis. This involves surgically removing visible cancer and bathing the abdominal cavity with heated chemotherapy fluid to reach any remaining cancer cells.

    Interventional procedures guidance
    Published
    3 March 2021
    View recommendations

    Sections for IPG688

  7. Robot-assisted kidney transplant (IPG609)

    Evidence-based recommendations on robot-assisted kidney transplant in adults. This involves the surgeon using a robot to help with a kidney transplant.

    Interventional procedures guidance
    Published
    25 April 2018
    View recommendations

    Sections for IPG609

  8. Percutaneous endovascular forearm arteriovenous fistula creation for haemodialysis access (IPG710)

    Evidence-based recommendations on percutaneous endovascular forearm arteriovenous fistula creation for haemodialysis access in adults. This involves using radiofrequency energy, or heat and pressure, to join an artery and vein in the forearm to create a fistula for haemodialysis access.

    Interventional procedures guidance
    Published
    27 October 2021
    View recommendations

    Sections for IPG710

  9. Coronary sinus narrowing device implantation for refractory angina (IPG712)

    Evidence-based recommendations on coronary sinus narrowing device implantation for refractory angina in adults. This involves putting a device into the coronary sinus to narrow it with the aim of improving the flow of oxygenated blood throughout the heart muscle.

    Interventional procedures guidance
    Published
    24 November 2021
    View recommendations

    Sections for IPG712

  10. Solriamfetol for treating excessive daytime sleepiness caused by obstructive sleep apnoea (TA777)

    Evidence-based recommendations on solriamfetol (Sunosi) for treating excessive daytime sleepiness caused by obstructive sleep apnoea in adults.

    Technology appraisal guidance
    Published
    9 March 2022
    View recommendations

    Sections for TA777

  11. Midostaurin for untreated acute myeloid leukaemia (TA523)

    Evidence-based recommendations on midostaurin (Rydapt) for untreated FLT3-mutation-positive acute myeloid leukaemia in adults.

    Technology appraisal guidance
    Published
    13 June 2018
    View recommendations

    Sections for TA523

  12. Avelumab for treating metastatic Merkel cell carcinoma (TA517)

    Evidence-based recommendations on avelumab (Bavencio) for metastatic Merkel cell carcinoma in adults.

    Technology appraisal guidance
    Last updated
    21 April 2021
    View recommendations

    Sections for TA517

  13. Acalabrutinib for treating chronic lymphocytic leukaemia (TA689)

    Evidence-based recommendations on acalabrutinib (Calquence) for treating chronic lymphocytic leukaemia in adults.

    Technology appraisal guidance
    Published
    21 April 2021
    View recommendations

    Sections for TA689

  14. Baricitinib for moderate to severe rheumatoid arthritis (TA466)

    Evidence-based recommendations on baricitinib (Olumiant) for moderate to severe rheumatoid arthritis in adults.

    Technology appraisal guidance
    Published
    9 August 2017
    View recommendations

    Sections for TA466

  15. Dietitian contribution to patient management:- How can the role of the dietitian contribute most effectively within a coeliac disease team?

    care and follow-up. Many of the common problems associated with the long-term management of coeliac disease happen because of...

    Research recommendation
    Published
    13 October 2015

  16. Natural history of progression to colorectal cancer in people at increased risk:- What is the natural history of progression to colorectal cancer in people with inflammatory bowel disease (IBD) or adenomas?

    grade of dysplasia and adenoma-related factors affect progression. Long-term studies (ideally with a follow-up of 20 years or longer)...

    Research recommendation
    Published
    9 June 2015

  17. Robot-assisted surgery for orthopaedic procedures: early value assessment (HTG743)

    Early value assessment (EVA) guidance on robot-assisted surgery for orthopaedic procedures.

    HealthTech guidance
    Published
    17 April 2025
    View recommendations

    Sections for HTG743

  18. Evidence summaries: new medicines – Integrated process statement (PMG11)

    This integrated process statement has been produced to explain how 'Evidence summaries: new medicines' (ESNMs) are developed. It provides an overview of the key process principles and describes all stages of the development of ESNMs

  19. Evidence on the safety and efficacy of percutaneous image-guided cryoablation of peripheral neuroma for chronic pain is inadequate in quality and quantity. Therefore, this procedure should only be used in thecontext of research. Find out what only in research means on the NICE interventional procedures guidance page.

    and the procedure, quality of life and pain reduction in the short and long term. For stump and other traumatic neuromas, further...

    Research recommendation
    Published
    3 February 2023

  20. Imaging of ankle fractures:- Is CT scanning in addition to initial plain film X-ray clinically effective and cost effective for planning surgical treatment of unstable/displaced ankle fractures compared with plain film X-ray alone?

    people every year. Outcomes following surgery are important for patients' long-term function and quality of life, and may also be...

    Research recommendation
    Published
    21 March 2016

  21. How can the effectiveness of workplace health policies and programmes be measured?

    effect- a later point, such as 12–18 months from the start, to measure longer-term effect.The design of studies should also consider the...

    Research recommendation
    Published
    5 October 2015

  22. Lung cancer in adults (QS17)

    This quality standard covers diagnosing and managing lung cancer in adults. It describes high-quality care in priority areas for improvement.

    Quality standard
    Last updated
    13 December 2019
    View quality statements

    Sections for QS17

  23. Evidence on the safety and efficacy of aortic remodelling hybrid stent insertion during surgical repair of an acute type A aortic dissection is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    patient selection and report 30-day mortality, quality of life, and long-term outcomes including aortic remodelling and complications....

    Research recommendation
    Published
    7 September 2022

  24. What is the role of arm and shoulder specific exercises compared with and/or used as an adjunct to established lymphoedema treatments (such as compression garments and complex decongestive therapy)?

    studies should have a follow-up period that is sufficient to capture long term outcomes including changes to current lymphoedema or any...

    Research recommendation
    Published
    6 July 2015

  25. Inducing labour (QS60)

    This quality standard covers the induction of labour in hospital outpatient or inpatient settings. It includes advice and care for pregnant women who are considering or having induction of labour. It describes high-quality care in priority areas for improvement.

    Quality standard
    Last updated
    4 November 2021
    View quality statements

    Sections for QS60

  26. Erdafitinib for treating unresectable or metastatic urothelial cancer with FGFR3 alterations after a PD-1 or PD-L1 inhibitor (TA1062)

    Evidence-based recommendations on erdafitinib (Balversa) for treating unresectable or metastatic urothelial cancer with FGFR3 alterations after a PD-1 or PD-L1 inhibitor in adults.

    Technology appraisal guidance
    Published
    12 May 2025

    Sections for TA1062

  27. What is the effectiveness of diuretics compared with placebo in preventing bronchopulmonary dysplasia (BPD) in preterm babies on respiratory support?

    BPD or neurodevelopmental outcomes. Although the studies looked at short-term adverse effects associated with diuretics, it was not...

    Research recommendation
    Published
    16 August 2019

  28. Effects of HRT on breast cancer risk:- What is the difference in the risk of breast cancer in menopausal women on HRT with progesterone, progestogen or selective oestrogen receptor modulators?

    morbidity and mortality from breast cancer in women who need HRT over the long term because of continuing menopausal symptoms. Source...

    Research recommendation
    Published
    11 December 2015

  29. Research is recommended to address uncertainties in the potential benefits to patients and the NHS of using VibraTip. Research is needed into the diagnostic accuracy of VibraTip compared with the 10 g monofilament and calibrated tuning fork in the diagnosis of peripheral neuropathy in people with diabetes. This research should also address the assessment of vibration perception compared with touch sensation in this clinical context.

    for detection of diabetic peripheral neuropathy. This should include longer term outcomes so that an accurate and comprehensive cost...

    Research recommendation
    Published
    9 June 2015

  30. Safety and efficacy of carotid stenting: What is the safety and efficacy of carotid stenting compared with carotid endarterectomy when these procedures are carried out within 2 weeks of TIA or recovered stroke?

    general anaesthetic might be high. However, neither the risk of stroke nor long-term outcomes after early carotid stenting are known. A...

    Research recommendation
    Published
    11 May 2022

  31. Delirium assessment tools:What is the diagnostic accuracy, and ease of implementation, of different delirium assessment tools: for people with pre-existing cognitive impairment, for example dementia, learning disability or severe depression for people who do not speak English as a first language in different settings, for example emergency departments, residential care homes or virtual consultations when delivered by different types of health and social care practitioners, for example healthcare assistants or allied health professionals such as paramedics?

    guidance Delirium: prevention, diagnosis and management in hospital and long-term care Number CG103 Date issued July 2010 Other details

    Research recommendation
    Published
    3 February 2023

  32. Acne vulgaris: management (NG198)

    This guideline covers management of acne vulgaris in primary and specialist care. It includes advice on topical and oral treatments (including antibiotics and retinoids), treatment using physical modalities, and the impact of acne vulgaris on mental health and wellbeing.

    NICE guideline
    Last updated
    7 December 2023
    View recommendations

    Sections for NG198

  33. Subcutaneous implantable cardioverter defibrillator insertion for preventing sudden cardiac death (IPG603)

    Evidence-based recommendations on subcutaneous implantable cardioverter defibrillator insertion for preventing sudden cardiac death. This involves placing a device under the skin of the chest, which detects and treats fast heartbeats called tachyarrhythmias.

    Interventional procedures guidance
    Published
    20 December 2017
    View recommendations

    Sections for IPG603

  34. Percutaneous deep venous arterialisation for chronic limb-threatening ischaemia (IPG773)

    Evidence-based recommendations on percutaneous deep venous arterialisation for chronic limb-threatening ischaemia. This involves making a hole between a blocked artery and a vein, allowing the blood to flow into the leg beyond the blockage.

    Interventional procedures guidance
    Published
    18 October 2023
    View recommendations

    Sections for IPG773

  35. Microwave ablation for treating liver metastases (IPG553)

    Evidence-based recommendations on microwave ablation for treating liver metastases in adults. This involves using heat energy to destroy cancer cells.

    Interventional procedures guidance
    Published
    27 April 2016
    View recommendations

    Sections for IPG553

  36. Thoracoscopic exclusion of the left atrial appendage (with or without surgical ablation) for non-valvular atrial fibrillation for the prevention of thromboembolism (IPG400)

    Evidence-based recommendations on thoracoscopic exclusion of the left atrial appendage in atrial fibrillation (with or without other cardiac surgery) for the prevention of thromboembolism. This involves inserting a camera and instruments through small cuts in the chest and closing the left atrial appendage.

    Interventional procedures guidance
    Published
    22 June 2011
    View recommendations

    Sections for IPG400

  37. Aortic remodelling hybrid stent insertion during surgical repair of an acute type A aortic dissection (IPG733)

    Evidence-based recommendations on aortic remodelling hybrid stent insertion for acute type A aortic dissection. This involves inserting a stent with material sewed on one end into part of the aorta.

    Interventional procedures guidance
    Published
    3 August 2022
    View recommendations

    Sections for IPG733

  38. Endoanchoring systems in endovascular aortic aneurysm repair (IPG725)

    Evidence-based recommendations on endoanchoring systems in endovascular aortic aneurysm repair. This involves using an anchoring device to hold a stent in place to prevent leaks in an aneurysm repair.

    Interventional procedures guidance
    Published
    25 May 2022
    View recommendations

    Sections for IPG725

  39. Hospital diagnostic radiology services:- What is the optimal configuration in terms of clinical and cost effectiveness of hospital diagnostic radiology services to support 7-day care of people presenting with medical emergencies? [See the evidence review on 7-day diagnostic radiology.]

    Hospital diagnostic radiology services:- What is the optimal configuration in terms of clinical and cost effectiveness of hospital...

    Research recommendation
    Published
    15 November 2018

  40. Developing NICE guidelines: the manual (PMG20)

    This manual explains the processes and methods used to develop and update NICE guidelines, the guidance that NICE develops covering topics across clinical care (in primary, secondary and community care settings), social care and public health. For more information on the other types of NICE guidance and advice (including technology appraisal guidance), see about NICE

  41. trublood-prostate for triaging and diagnosing people with prostate cancer symptoms (MIB268)

    NICE has developed a medtech innovation briefing (MIB) on trublood-prostate for triaging and diagnosing people with prostate cancer symptoms .

    Medtech innovation briefing
    Published
    13 July 2021

  42. Cemiplimab for treating advanced cutaneous squamous cell carcinoma (TA802)

    Evidence-based recommendations on cemiplimab (Libtayo) for metastatic or locally advanced cutaneous squamous cell carcinoma in adults.

    Technology appraisal guidance
    Published
    29 June 2022
    View recommendations

    Sections for TA802

  43. Comprehensive assessment versus a brief assessment:- For people with a suspected common mental health disorder, what is the clinical and cost effectiveness of using a comprehensive assessment (conducted by mental health professional) versus a brief assessment (conducted by a paraprofessional)?

    answered using a randomised controlled design that reports short- and medium-term outcomes (including cost-effectiveness outcomes) of at...

    Research recommendation
    Published
    9 June 2015

  44. Evidence on the safety and efficacy of biodegradable spacer insertion to reduce rectal toxicity during radiotherapy for prostate cancer is limited in quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    ofradiotherapy technique and device used, improvement in quality of life, and long-term efficacy and safety. It should also identify...

    Research recommendation
    Published
    9 March 2023

  45. Support needs of parents:- What are the experiences and concerns of parents of children with faltering growth?

    or unheard. Faltering growth happens when children are young so can have a long-term impact on the child–parent relationship. There are...

    Research recommendation
    Published
    15 October 2018

  46. Pharmacological therapies:- What is the clinical and cost effectiveness of benzodiazepines for the acute management of low back pain?

    extremely small. Benzodiazepines are not without risk of harm, even for short-term use. Because of this, there is a need to find out if...

    Research recommendation
    Published
    13 February 2017

  47. Drug misuse prevention (QS165)

    This quality standard covers the prevention or delay of harmful use of drugs by children, young people and adults most likely to start using drugs, or already experimenting or using drugs occasionally. This includes illegal psychoactive substances, solvents, volatile substances, image- and performance-enhancing drugs, prescription-only medicines and over-the-counter medicines. It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    29 March 2018
    View quality statements

    Sections for QS165

  48. Care of dying adults in the last days of life (QS144)

    This quality standard covers the clinical care of adults (aged 18 and over) who are dying, during the last 2 to 3 days of life. It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    2 March 2017
    View quality statements

    Sections for QS144

  49. Bladder cancer (QS106)

    This quality standard covers diagnosing and managing bladder cancer in adults (aged 18 and over) referred from primary care. It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    17 December 2015
    View quality statements

    Sections for QS106

  50. Parkinson's disease (QS164)

    This quality standard covers the management of Parkinson’s disease in adults. It does not include treatment of parkinsonism not caused by Parkinson’s disease. It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    9 February 2018
    View quality statements

    Sections for QS164