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  1. Psychological assessment:- What is the most effective measure of psychological functioning to use as a test for thresholds of concern in people with cystic fibrosis?

    generic measures (for example for depression and anxiety). People with a long-term physical health condition are more likely to present...

    Research recommendation
    Published
    18 October 2018

  2. Predictive accuracy of the WPPSI-IV at age 4 years (uncorrected) for children born preterm:- What is the accuracy of a Wechsler Preschool and Primary Scale of Intelligence 4th Edition (WPPSI-IV) assessment at age 4 years (uncorrected) for predicting later educational difficulties in children of primary school age who were born before 28+0 weeks' gestation?

    that educational support can be provided in order to reduce the risk of long-term learning disability (intellectual disability). Source...

    Research recommendation
    Published
    15 October 2018

  3. Pilon fractures:- In adults with closed pilon fractures, what method of fixation provides the best clinical and cost effectiveness outcomes as assessed by function and incidence of major complications at 2 years (stratified for timing of definitive surgery early [under 36 hours] versus later [over 36 hours])?

    surface is vulnerable to degeneration. Therefore, the injury can lead to long-term disability, most commonly arthritis with pain and...

    Research recommendation
    Published
    21 March 2016

  4. Developmental follow-up of children and young people born preterm (QS169)

    This quality standard covers the developmental follow-up of babies, children and young people under 18 years who were born preterm (before 37+0 weeks of pregnancy). It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    18 May 2018
    View quality statements

    Sections for QS169

  5. Anaphylaxis (QS119)

    This quality standard covers care after emergency treatment for suspected anaphylaxis, including assessment and referral to specialist allergy services. It describes high-quality care in priority areas for improvement.

    Quality standard
    Last updated
    31 July 2024
    View quality statements

    Sections for QS119

  6. Diabetes in pregnancy (QS109)

    This quality standard covers managing diabetes and its complications in women who are planning a pregnancy or are already pregnant. It includes care for women with pre-existing diabetes before and during pregnancy, and diagnosis and management of gestational diabetes. It describes high-quality care in priority areas for improvement.

    Quality standard
    Last updated
    10 January 2023
    View quality statements

    Sections for QS109

  7. Transient loss of consciousness ('blackouts') in over 16s (QS71)

    This quality standard covers assessing, diagnosing and referring people (aged 16 and over) who have had a transient loss of consciousness (often called a blackout). It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    2 October 2014
    View quality statements

    Sections for QS71

  8. Allogeneic stem cell transplantation:- What is the effectiveness of combined autologous–allogeneic stem cell transplantation compared with autologous stem cell transplantation, plus consolidation and maintenance treatment in chemosensitive patients at first response or first relapse?

    important:- There are conflicting data from a small number of studies on long-term survival following auto/allo stem cell...

    Research recommendation
    Published
    5 April 2016

  9. Stopping antiviral treatment in HBeAg-negative disease:- Further research should be undertaken to evaluate the clinical and cost effectiveness of hepatitis B surface antigen (HBsAg) quantitative assays in determining treatment duration in hepatitis B e antigen- (HBeAg) negative disease.

    HBeAg-negative disease would transform current treatment strategies. People on long-term nucleoside or nucleotide analogues could safely...

    Research recommendation
    Published
    9 June 2015

  10. What are the most clinically effective interventions (including social prescribing and structured community support) for managing post‑COVID‑19 syndrome? Does effectiveness vary for different population groups (for example sex, age, socioeconomic group, black, Asian and minority ethnic group communities or people with learning disabilities)? Do any symptoms of post‑COVID‑19 syndrome predict the need for specialist intervention? Are there clusters of symptoms that identify response to interventions in post‑COVID‑19 syndrome? What is the clinical effectiveness of different service models of multimodality/multidisciplinary post‑COVID‑19 syndrome rehabilitation in improving patient‑reported outcomes (such as quality of life)? What is the clinical effectiveness of exercise interventions for people with post‑COVID‑19 syndrome? Does effectiveness vary for different population groups (for example sex, age, socioeconomic group, black, Asian and minority ethnic group communities or people with learning disabilities)? Does early exercise rehabilitation assist in improving symptoms of post‑COVID‑19 syndrome?

    Comes from guidance COVID-19 rapid guideline: managing the long-term effects of COVID-19 Number NG188 Date issued December

    Research recommendation
    Published
    12 November 2021

  11. Predicting life expectancy:- Is it possible to analyse primary care data to identify characteristics that affect life expectancy and to develop algorithms and prediction tools for patients and healthcare providers to predict reduced life expectancy?

    information that could inform decisions about starting or continuing long-term preventive treatments. Conversely younger people with...

    Research recommendation
    Published
    18 October 2016

  12. What is the clinical effectiveness and safety of vitamin D for treating COVID-19 in children, young people and adults?

    admission to intensive care symptom alleviation adherence to therapy long-term effects of COVID-19 (at least 4 weeks from acute COVID-19...

    Research recommendation
    Published
    14 July 2022

  13. Minimally invasive pancreatectomy:- Prospective randomised trials should be undertaken to compare the effectiveness of minimally invasive pancreatectomy or pancreatoduodenectomy (laparoscopic or robotic) with open pancreatectomy or pancreatoduodenectomy in people with pancreatic cancer.

    hospital stay- time to return to normal activity- mortality of surgery- long-term survival after surgery- quality of life, patient...

    Research recommendation
    Published
    13 November 2018

  14. ClearWay RX for drug delivery to coronary artery thrombotic lesions (MIB55)

    NICE has developed a medtech innovation briefing (MIB) on ClearWay RX for drug delivery to coronary artery thrombotic lesions

    Medtech innovation briefing
    Published
    11 March 2016

  15. Transcutaneous electrical stimulation of the supraorbital nerve for treating and preventing migraine (IPG740)

    Evidence-based recommendations on transcutaneous electrical stimulation of the supraorbital nerve for treating and preventing migraine in adults. This involves attaching a small device on the forehead to send small electrical currents to the nerves that bring sensation to the upper eyelids, forehead and scalp.

    Interventional procedures guidance
    Published
    26 October 2022
    View recommendations

    Sections for IPG740

  16. Transperineal laser ablation for treating lower urinary tract symptoms of benign prostatic hyperplasia (IPG798)

    Evidence-based recommendations on transperineal laser ablation for treating lower urinary tract symptoms of benign prostatic hyperplasia. This involves using laser energy to destroy some of the prostate tissue.

    Interventional procedures guidance
    Published
    8 January 2025
    View recommendations

    Sections for IPG798

  17. Liposuction for chronic lipoedema (IPG721)

    Evidence-based recommendations on liposuction for chronic lipoedema in adults. This involves using suction to remove abnormal fat.

    Interventional procedures guidance
    Published
    29 March 2022
    View recommendations

    Sections for IPG721

  18. Endoscopic radiofrequency ablation for Barrett's oesophagus with low‑grade dysplasia or no dysplasia (IPG496)

    Evidence-based recommendations on endoscopic radiofrequency ablation for Barrett’s oesophagus with low-grade dysplasia or no dysplasia. This involves using radiofrequency (heat) energy to destroy the abnormal cells and promote the growth of healthy normal cells.

    Interventional procedures guidance
    Published
    23 July 2014
    View recommendations

    Sections for IPG496

  19. Behaviour change: digital and mobile health interventions (NG183)

    This guideline covers interventions that use a digital or mobile platform to help people eat more healthily, become more active, stop smoking, reduce their alcohol intake or practise safer sex. The interventions include those delivered by text message, apps, wearable devices or the internet. The guideline only includes those that are delivered by the technology itself and not by healthcare professionals using technology to deliver interventions.

    NICE guideline
    Published
    7 October 2020
    View recommendations

    Sections for NG183

  20. Airway clearance techniques:- How effective are daily airway clearance techniques in maintaining lung function in infants and children with cystic fibrosis?

    impact on the lives of parents, family members and carers, as well as long-term clinical outcomes for infants and children with cystic...

    Research recommendation
    Published
    6 November 2018

  21. What is the utility of routine cardiovascular evaluation for asymptomatic people with FH?

    Consideration should also be given to the feasibility of conducting a long-term randomised trial to compare the differences in morbidity...

    Research recommendation
    Published
    15 November 2019

  22. FRAX and QFracture in adults receiving bone protective therapy:- What is the utility of FRAX and QFracture in adults receiving bone protective therapy?

    important:- Because of concerns about rare but serious side-effects of long-term anti-resorptive therapy, many physicians prescribe...

    Research recommendation
    Published
    9 June 2015

  23. 1.1 Evidence on the safety of electrical stimulation to improve muscle strength in chronic respiratory conditions, chronic heart failure and chronic kidney disease shows no major safety concerns. For people who are having an acute exacerbation of their chronic condition and are unable to exercise, evidence of efficacy is adequate to support the use of this procedure provided that standard arrangements are in place for clinical governance, consent and audit.   Find out  what standard arrangements mean on the NICE website . For people who are able to exercise, evidence on efficacy is inadequate in quality. Therefore, this procedure should only be used in the context of research. Find out  what only in research means on the NICE website .

    explanatory notes(if applicable) Further research should include long term, suitably powered and appropriately controlled randomised...

    Research recommendation
    Published
    10 August 2020

  24. The health-related quality-of-life evidence of patients with perianal fistulas is also lacking, therefore further research is recommended. Any research should measure the effect of treatment using preference-based measures (such as use of the EQ-5D questionnaire).

    submitted after consultation did not clarify the uncertainties around the long-term benefits of darvadstrocel compared with placebo...

    Research recommendation
    Published
    19 March 2019

  25. Transition in special groups: looked-after young people:- What is the most effective way of supporting care leavers in transition from children's to adults' health services?

    important:- The role of birth parents in the management of childhood-onset long-term physical and mental health conditions is essential...

    Research recommendation
    Published
    21 March 2016

  26. How cost effective are fluoride varnish programmes and tooth-brushing schemes?

    It should include studies with sufficient follow-up to consider the long term impact of poor oral health. Research should include...

    Research recommendation
    Published
    9 June 2015

  27. How can healthy habits that promote oral health be supported and encouraged in families with children at high risk of poor oral health?

    It should include studies with sufficient follow-up to consider the long term impact of poor oral health. Research should include...

    Research recommendation
    Published
    9 June 2015

  28. The effects of stopping and/or switching drug treatments to control blood glucose levels: In adults with type 2 diabetes, what are the effects of stopping and/or switching drug treatments to control blood glucose levels, and what criteria should inform the decision?

    limited understanding of the short- and long‑term effects of stopping a therapy and switching to another in terms of...

    Research recommendation
    Published
    16 December 2021

  29. Emotional and psychological support and interventions:- What emotional support do children and young people with life-limiting conditions and their parents or carers need, and how would they like these needs to be addressed?

    research recommendation

    Research recommendation
    Published
    1 November 2017

  30. Intraoperative red blood cell salvage during radical prostatectomy or radical cystectomy (IPG258)

    Evidence-based recommendations on intraoperative red blood cell salvage during radical prostatectomy or radical cystectomy. This involves collecting the solid components of the blood lost during an operation and transfusing it back to the same patient.

    Interventional procedures guidance
    Published
    26 April 2008
    View recommendations

    Sections for IPG258

  31. Endoscopic mucosal resection and endoscopic submucosal dissection of non-ampullary duodenal lesions (IPG359)

    Evidence-based recommendations on endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) of non-ampullary duodenal lesions. This involves using a long camera inserted through the mouth to view the area and removing the abnormal parts of the lining with special instruments.

    Interventional procedures guidance
    Published
    27 October 2010
    View recommendations

    Sections for IPG359

  32. Minimally invasive total hip replacement (IPG363)

    Evidence-based recommendations on minimally invasive total hip replacement. This involves replacing the damaged hip joint (the top part of the upper leg bone and the socket in the hip bone that it fits into) with an artificial one.

    Interventional procedures guidance
    Published
    27 October 2010
    View recommendations

    Sections for IPG363

  33. Transcatheter endovascular closure of perimembranous ventricular septal defect (IPG336)

    Evidence-based recommendations on transcatheter endovascular closure of perimembranous ventricular septal defect. This involves inserting a small blocking device (called an occluder) into the heart.

    Interventional procedures guidance
    Published
    24 March 2010
    View recommendations

    Sections for IPG336

  34. Gallstone disease: diagnosis and management (CG188)

    This guideline covers diagnosing and managing gallstone disease in adults. It aims to reduce variation in care by promoting the most effective treatments, and to improve the advice given to people with gallstone disease before and after treatment.

    Clinical guideline
    Published
    29 October 2014
    View recommendations

    Sections for CG188

  35. Adults' uptake of and engagement with interventions for social anxiety disorder:- What methods are effective in improving uptake of and engagement with interventions for adults with social anxiety disorder?

    a randomised controlled trial (RCT) design that reports short- and medium-term outcomes (including cost effectiveness) of at least 18...

    Research recommendation
    Published
    9 June 2015

  36. Education programme: Does a staff education programme (compared with an educational leaflet or usual care) reduce the incidence of delirium and improve the recognition and recording of delirium in people in hospital?

    guidance Delirium: prevention, diagnosis and management in hospital and long-term care Number CG103 Date issued July 2010 Other details

    Research recommendation
    Published
    3 February 2023

  37. Prophylactic cervical cerclage compared with prophylactic vaginal progesterone for preventing preterm birth:- What is the clinical effectiveness of prophylactic cervical cerclage alone compared with prophylactic vaginal progesterone alone and with both strategies together for preventing preterm birth in women with a short cervix and a history of spontaneous preterm birth?

    birth causes significant neonatal morbidity and mortality, as well as long-term disability. Therefore strategies for preventing preterm...

    Research recommendation
    Published
    11 December 2015

  38. Is a medication review more clinically and cost effective at reducing the suboptimal use of medicines and medicines-related patient safety incidents, compared with usual care or other interventions, in children?

    the benefit from them having medication reviews. There may be some longer-term gains with this approach, as from a young age the child...

    Research recommendation
    Published
    9 June 2015

  39. Remdesivir and tixagevimab plus cilgavimab for treating COVID-19 (TA971)

    Evidence-based recommendations on remdesivir (Veklury) and tixagevimab plus cilgavimab (Evusheld) for treating COVID-19.

    Technology appraisal guidance
    Published
    8 May 2024
    View recommendations

    Sections for TA971

  40. Ivosidenib for treating advanced cholangiocarcinoma with an IDH1 R132 mutation after 1 or more systemic treatments (TA948)

    Evidence-based recommendations on ivosidenib (Tibsovo) for treating locally advanced or metastatic cholangiocarcinoma with an IDH1 R132 mutation in adults after 1 or more systemic treatments.

    Technology appraisal guidance
    Published
    31 January 2024
    View recommendations

    Sections for TA948

  41. The effect of injectable contraceptives on bone mineral density in women who have used DMPA for longer than 2 years is uncertain. Adequately powered surveys or cross‑sectional studies are needed to examine the recovery of bone mineral density after discontinuation of DMPA after long‑term and very long‑term use. Studies are also needed to examine the risk of bone fractures in older women.

    of bone mineral density after discontinuation of DMPA after long‑term and very long‑term use. Studies are also needed to...

    Research recommendation
    Published
    25 October 2019

  42. Antibiotic resistance in treating spontaneous bacterial peritonitis:- How frequently does antibiotic resistance occur, and how significant are antibiotic treatment-related complications when antibiotics are used for the primary prevention of spontaneous bacterial peritonitis in people at high risk of having, or developing, cirrhosis?

    prevalence and consequences of antibacterial resistance that may occur during long-term oral antibiotic therapy when used to prevent...

    Research recommendation
    Published
    11 January 2024

  43. Early revascularisation strategy for people with angina and multivessel disease:- In people with stable angina and multivessel disease (including left main stem disease) whose symptoms are controlled with optimal drug treatment, would an initial treatment strategy of revascularisation be clinically and cost effective compared with continued drug treatment?

    determine whether early investigation and revascularisation can improve longer term survival. People with stable angina may be...

    Research recommendation
    Published
    9 June 2015

  44. FRAX and QFracture in adults living in residential care:- What is the utility of FRAX and QFracture in detecting risk of fragility fracture in adults living in residential care?

    to the 9th decade and use 10-year fracture risk, may underestimate short-term risk in care home residents, who have a mean age of...

    Research recommendation
    Published
    9 June 2015

  45. Current evidence on the safety and efficacy of radially emitting laser fibre treatment of an anal fistula is limited in quantity and quality. Therefore, although there are no major safety concerns, this procedure should only be used with special arrangements  for clinical governance, consent, and audit or research.

    selection, including fistula size, recurrence rates in the medium and long term, and quality-of-life outcomes. Source guidance details...

    Research recommendation
    Published
    15 November 2019

  46. How safe are drugs used to treat bipolar disorder in pregnancy and the postnatal period?

    not well described. The question should be addressed by establishing a long-term register of women with bipolar disorder to provide data...

    Research recommendation
    Published
    13 July 2017

  47. In adults having elective knee replacement, what is the clinical and cost effectiveness of total knee replacement with patella resurfacing compared with selective resurfacing?

    more than offset by reduced numbers of hospital readmissions in the long term. Source guidance details Comes from guidance Joint

    Research recommendation
    Published
    10 August 2020

  48. Individual versus group CBT for children and young people with social anxiety disorder:- What is the clinical and cost effectiveness of individual and group CBT for children and young people with social anxiety disorder?

    young people with social anxiety disorder. It should report short- and medium-term outcomes (including cost effectiveness) with a...

    Research recommendation
    Published
    9 June 2015

  49. Lifestyle interventions (diet and exercise):- Are specialist lifestyle interventions (diet and exercise) effective, compared with no specialist lifestyle interventions, for women with endometriosis?

    notes(if applicable) Why this is important:- Endometriosis is a long-term condition that can cause acute and chronic pain, and fatigue....

    Research recommendation
    Published
    15 October 2018

  50. Tools for case identification for cognitive impairment in criminal justice system populations:- What are the reliable and valid tools to identify cognitive impairment among people in contact with the criminal justice system (including people who have experienced physical trauma, neurodevelopmental disorders or other acquired cognitive impairment)?

    effective management strategies, could be important in limiting the long-term impact of acquired cognitive impairment. However, there is...

    Research recommendation
    Published
    16 May 2017