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  1. What community-based interventions are effective and cost effective in improving dietary habits affecting the oral health of children and adults, and in particular those at high risk of poor oral health?

    It should include studies with sufficient follow-up to consider the long term impact of poor oral health. Research should include...

    Research recommendation
    Published
    9 June 2015

  2. What community-based interventions are effective and cost effective in improving oral health and reducing oral health inequalities among groups of adults at high risk of poor oral health?

    It should include studies with sufficient follow-up to consider the long term impact of poor oral health. Research should include...

    Research recommendation
    Published
    9 June 2015

  3. What community-based interventions are effective and cost effective in improving oral health and reducing oral health inequalities among groups of children at high risk of poor oral health?

    It should include studies with sufficient follow-up to consider the long term impact of poor oral health. Research should include...

    Research recommendation
    Published
    9 June 2015

  4. Mental health interventions to support discharge from general inpatient hospital settings:- What interventions are cost effective in supporting people with mental health difficulties on discharge from general hospital inpatient settings?

    delirium because early identification of difficulties might lead to long-term savings for the public sector and society.Research is...

    Research recommendation
    Published
    29 January 2016

  5. What is the relative effectiveness and cost effectiveness of the different components of multi-component, community-based oral health improvement programmes?

    It should include studies with sufficient follow-up to consider the long term impact of poor oral health. Research should include...

    Research recommendation
    Published
    9 June 2015

  6. Tests in secondary care to identify people at high risk of ovarian cancer (HTG453)

    Evidence-based recommendations on tests in secondary care to identify people at high risk of ovarian cancer. The tests are the IOTA ADNEX model, Overa (MIA2G), RMI I (at thresholds other than 250), ROMA and IOTA Simple Rules.

    HealthTech guidance
    Published
    15 November 2017
    View recommendations

    Sections for HTG453

  7. Narcolepsy with or without cataplexy in adults: pitolisant (ES8)

    Summary on the evidence on pitolisant for treating narcolepsy with or without cataplexy to inform local NHS planning and decision-making

    Evidence summary
    Published
    14 March 2017

  8. Biodegradable spacer insertion to reduce rectal toxicity during radiotherapy for prostate cancer (IPG752)

    Evidence-based recommendations on biodegradable spacer insertion to reduce rectal toxicity during radiotherapy for prostate cancer. This involves pushing the rectum slightly away from the prostate by inserting a balloon or injecting a gel (spacer) between them.

    Interventional procedures guidance
    Published
    7 February 2023
    View recommendations

    Sections for IPG752

  9. Infracoccygeal sacropexy using mesh to repair vaginal vault prolapse (IPG581)

    Evidence-based recommendations on infracoccygeal sacropexy using mesh to repair vaginal vault prolapse in women. This involves attaching mesh from the buttocks to the top of the vagina to hold the vagina in place.

    Interventional procedures guidance
    Published
    28 June 2017
    View recommendations

    Sections for IPG581

  10. Phrenic nerve transfer in brachial plexus injury (IPG468)

    Evidence-based recommendations on phrenic nerve transfer in brachial plexus injury. This involves finding the phrenic nerve, cutting it and joining it to the damaged nerve in the brachial plexus.

    Interventional procedures guidance
    Published
    27 November 2013
    View recommendations

    Sections for IPG468

  11. Are comprehensive early interventions that combine multiple elements and are delivered by parents and teachers (for example, the Learning Experiences – an Alternative Program for Preschoolers and their Parents [LEAP] model) effective in managing the core features of autism and coexisting difficulties (such as adaptive behaviour and developmental skills) in pre‑school children?

    intensity required to ensure effectiveness of the programme, as well as longer-term outcomes. Source guidance details Comes from...

    Research recommendation
    Published
    10 August 2021

  12. Preventing behaviour that challenges from developing in children aged under 5 years with a learning disability:- Can positive behaviour support provided for children aged under 5 years with a learning disability reduce the risk of developing behaviour that challenges?

    the interventions in a large scale randomised controlled trial with long-term follow-up- evaluating the implementation of the...

    Research recommendation
    Published
    5 October 2015

  13. Pharmacological treatment: In people in hospital who have delirium, which is the most effective medication (atypical antipsychotics, typical antipsychotics or benzodiazepines) compared with placebo or each other for treating delirium?

    guidance Delirium: prevention, diagnosis and management in hospital and long-term care Number CG103 Date issued July 2010 Other details

    Research recommendation
    Published
    3 February 2023

  14. What community-based interventions are effective and cost effective at improving the uptake of, and reducing inequalities in the use of, dental services by groups of adults and children at high risk of poor oral health?

    It should include studies with sufficient follow-up to consider the long term impact of poor oral health. Research should include...

    Research recommendation
    Published
    9 June 2015

  15. Parent training programmes for children aged 12 years and over with a conduct disorder:- What is the effectiveness of parent training programmes for conduct disorders in children and young people aged 12 years and over?

    using a randomised controlled trial (RCT) design reporting short- and medium-term outcomes, including cost effectiveness, over at least...

    Research recommendation
    Published
    9 June 2015

  16. Maintenance treatment:- In the maintenance treatment of bipolar disorder, what is the relative effect on quality of life of lithium, an antipsychotic (haloperidol, olanzapine, quetiapine or risperidone), or a combination of lithium and an antipsychotic?

    antipsychotic medication are known to reduce the risk of relapse when used long-term in people with bipolar disorder. Relapses do still...

    Research recommendation
    Published
    9 June 2015

  17. What overall osmolality (or concentration of calcium and glucose/dextrose) in parenteral nutrition can determine whether to administer centrally or peripherally?

    was supported by the evidence) when use of a peripheral line will be short term, and should be used when parenteral nutrition would...

    Research recommendation
    Published
    17 March 2020

  18. Thoracoscopically assisted mitral valve surgery (IPG245)

    Evidence-based recommendations on thoracoscopically assisted mitral valve surgery. This involves repairing a defective valve through one or more small incisions between the ribs rather than one large incision through the breastbone (sternum).

    Interventional procedures guidance
    Published
    12 December 2007
    View recommendations

    Sections for IPG245

  19. Reablement:- How effective and cost effective are repeated periods of reablement, and reablement that lasts longer than 6 weeks?

    weeks, or both.Comparative studies are also needed to understand the long-term impact of duration on costs and patient outcomes, by...

    Research recommendation
    Published
    15 October 2018

  20. Angioplasty versus bypass surgery for treating people with critical limb ischaemia caused by disease of the infra-geniculate arteries:- What is the clinical and cost effectiveness of a 'bypass surgery first' strategy compared with an 'angioplasty first' strategy for treating people with critical limb ischaemia caused by disease of the infra-geniculate (below the knee) arteries?

    surgery may be associated with significant morbidity, the resulting long-term amputation-free survival rates are generally good. In...

    Research recommendation
    Published
    9 June 2015

  21. Compression after interventional treatment:- What is the clinical and cost effectiveness of compression bandaging or hosiery after interventional treatment for varicose veins compared with no compression? If there is benefit, how long should compression bandaging or hosiery be worn for?

    improve quality of life for people with varicose veins and reduce the longer-term need for retreatment. Source guidance details Comes...

    Research recommendation
    Published
    9 June 2015

  22. Compulsion, control and restraint:- For people using adult mental health services, how is compulsory treatment and 'control and restraint' used in different settings and what is the impact on the service user?

    compulsory treatment and restraint on service user experience, and its longer-term impact. Source guidance details Comes from guidance...

    Research recommendation
    Published
    9 June 2015

  23. Specific versus generic CBT for children and young people with social anxiety disorder:- What is the clinical and cost effectiveness of specific CBT for children and young people with social anxiety disorder compared with generic anxiety-focused CBT?

    question should be answered using an RCT design, reporting short- and medium-term outcomes (including cost-effectiveness) with a...

    Research recommendation
    Published
    9 June 2015

  24. Pharmacological treatments for headache prophylaxis to aid withdrawal treatment in medication overuse headache:- Does a course of steroid treatment or pharmacological treatments used for headache prophylaxis help people with medication overuse headaches withdraw from medication?

    overuse headache find it difficult to withdraw abruptly because in the short term their headaches can become much worse. The use of...

    Research recommendation
    Published
    9 June 2015

  25. Mobi-C for cervical disc replacement (MIB70)

    NICE has developed a medtech innovation briefing (MIB) on Mobi-C for cervical disc replacement

    Medtech innovation briefing
    Published
    28 June 2016

  26. Early and metastatic HER2-positive breast cancer: subcutaneous trastuzumab (ESNM13)

    Summary of the evidence on subcutaneous trastuzumab for HER2-positive breast cancer to inform local NHS planning and decision-making

    Evidence summary
    Published
    13 March 2013

  27. Twin and triplet pregnancy (NG137)

    This guideline covers care for pregnant women and pregnant people with a twin or triplet pregnancy in addition to routine care during pregnancy and labour. It aims to reduce the risk of complications and improve outcomes.

    NICE guideline
    Last updated
    9 April 2024
    View recommendations

    Sections for NG137

  28. Biopatch for venous or arterial catheter sites (MIB117)

    NICE has developed a medtech innovation briefing (MIB) on Biopatch for venous or arterial catheter sites .

    Medtech innovation briefing
    Published
    9 August 2017

  29. Content and nature of effective de-escalation:- What is the content and nature of effective de-escalatory actions, interactions and activities used by mental health nurses, including the most effective and efficient means of training nurses to usethem in a timely and appropriate way?

    guidance details Comes from guidance Violence and aggression: short-term management in mental health, health and community settings...

    Research recommendation
    Published
    5 October 2015

  30. Reducing car ownership:- Does reducing car use or ownership change physical activity levels? Are effects maintained over time?

    to understand how it interacts with physical activity and, in the longer term, health status. An objective measure of physical activity...

    Research recommendation
    Published
    15 November 2018

  31. Long duration or very frequent manual restraint:- In what circumstances and how often are long-duration or repeated manual restraint used, and what alternatives are there that are safer and more effective?

    guidance details Comes from guidance Violence and aggression: short-term management in mental health, health and community settings...

    Research recommendation
    Published
    1 October 2015

  32. The evidence on the safety of transurethral laser ablation for recurrent non-muscle-invasive bladder cancer shows that there are no major safety concerns. However, current evidence on its efficacy is limited in quality and quantity. Therefore, this procedure should only be used with  special arrangements   for clinical governance, consent, and audit or research.

    investigate patient selection, types of laser used, tumour recurrence and long-term follow up. Source guidance details Comes from...

    Research recommendation
    Published
    15 November 2019

  33. Cannabidiol with clobazam for treating seizures associated with Lennox–Gastaut syndrome (TA615)

    Evidence-based recommendations on cannabidiol (Epidyolex) with clobazam for seizures associated with Lennox–Gastaut syndrome in people aged 2 years and older.

    Technology appraisal guidance
    Published
    18 December 2019
    View recommendations

    Sections for TA615

  34. Episcissors-60 show promise for mediolateral episiotomy. But there is currently not enough evidence to support the case for routine adoption in the NHS. Research is recommended to address uncertainties about the efficacy and safety of using Episcissors-60. This research should: - determine if using Episcissors-60 in addition to other care bundle measures is more effective in achieving an optimal episiotomy angle and in preventing episiotomy-related obstetric anal sphincter injuries (OASI) than standard episiotomy scissors - include patient-reported outcome measures - address potential equality considerations by ensuring patients at greatest risk of OASI are recruited - determine the relative cost of using Episcissors-60 compared with standard episiotomy scissors.

    angle is important to reduce the chance of OASI, which can have severe long-term effects, such as faecal incontinence. Because not much...

    Research recommendation
    Published
    17 March 2020

  35. Transapical transcatheter mitral valve-in-ring implantation after failed annuloplasty for mitral valve repair (IPG707)

    Evidence-based recommendations on transapical transcatheter mitral valve-in-ring implantation after failed annuloplasty for mitral valve repair in adults. This involves inserting a bioprosthetic mitral valve into an existing mitral valve ring to treat a leaking mitral valve, without needing repeat open heart surgery.

    Interventional procedures guidance
    Published
    22 September 2021
    View recommendations

    Sections for IPG707

  36. Mexiletine for treating the symptoms of myotonia in non-dystrophic myotonic disorders (TA748)

    Evidence-based recommendations on mexiletine (Namuscla) for treating the symptoms of myotonia in adults with non-dystrophic myotonic disorders.

    Technology appraisal guidance
    Published
    1 December 2021
    View recommendations

    Sections for TA748

  37. COVID-19 rapid evidence summary: Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) for people with or at risk of COVID-19 (ES25)

    This evidence summary was produced at the start of the COVID-19 pandemic, when evidence was emerging. It has been withdrawn as the content is no longer relevant. See NICE's COVID-19 rapid guideline: managing COVID-19 for current guidance.

    Evidence summary: COVID-19 rapid summary
    Published
    21 May 2020

  38. Use of hearing aids and incidence of dementia:- In adults with hearing loss, does the use of hearing aids reduce the incidence of dementia?

    the incidence of dementia is increasing. Dementia has considerable long-term costs for people with dementia, their families and the...

    Research recommendation
    Published
    10 December 2018

  39. NICE health technology evaluation topic selection: the manual (PMG37)

    This manual sets out the process for deciding how topics are identified, selected and routed for NICE guidance developed by the Centre for Health Technology Evaluation (CHTE). This includes diagnostics, highly specialised technologies, interventional procedures, medical technologies and technology appraisal guidance

  40. Ovarian cancer (QS18)

    This quality standard covers the identification and management of familial and genetic risk and the recognition and management of ovarian, fallopian tube and primary peritoneal cancer or borderline ovarian cancer in women, trans men and non-binary people aged 18 and over with female reproductive organs (ovaries, fallopian tubes or a uterus). It describes high-quality care in priority areas for improvement.

    Quality standard
    Last updated
    5 February 2025
    View quality statements

    Sections for QS18

  41. Mental health of adults in contact with the criminal justice system (QS163)

    This quality standard covers recognising, assessing and managing mental health problems in adults (aged 18 and over) who are in contact with the criminal justice system (this includes police contact, court and prison custody, street triage, liaison and diversion services, and probation services). It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    9 February 2018
    View quality statements

    Sections for QS163

  42. Motor neurone disease (QS126)

    This quality standard covers assessing and managing motor neurone disease, including care, support and planning after diagnosis. It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    27 July 2016
    View quality statements

    Sections for QS126

  43. Pemetrexed for the treatment of malignant pleural mesothelioma (TA135)

    Evidence-based recommendations on pemetrexed for treating malignant pleural mesothelioma in adults.

    Technology appraisal guidance
    Published
    23 January 2008
    View recommendations

    Sections for TA135

  44. The NICE public health guidance development process (third edition) (PMG5)

    This manual describes how public health guidance is produced, and explains the stages of guidance development, the different activities, roles and responsibilities of different groups of people involved at different stages

  45. Endoscopic full thickness removal of non-lifting colonic polyps (IPG580)

    Evidence-based recommendations on endoscopic full thickness removal of non-lifting colonic polyps. This involves using a special device to remove the polyp and seal the bowel wall closed afterwards.

    Interventional procedures guidance
    Published
    24 May 2017
    View recommendations

    Sections for IPG580

  46. Prasugrel with percutaneous coronary intervention for treating acute coronary syndromes (TA317)

    Evidence-based recommendations on prasugrel (Efient) with percutaneous coronary intervention for treating acute coronary syndromes in adults.

    Technology appraisal guidance
    Published
    23 July 2014
    View recommendations

    Sections for TA317

  47. Nirmatrelvir plus ritonavir, sotrovimab and tocilizumab for treating COVID-19 (TA878)

    Evidence-based recommendations on nirmatrelvir plus ritonavir (Paxlovid), sotrovimab (Xevudy) and tocilizumab (RoActemra) for treating COVID-19.

    Technology appraisal guidance
    Last updated
    1 May 2025
    View recommendations

    Sections for TA878

  48. The evidence on the safety of reinforcement of a permanent stoma with a synthetic or biological mesh to prevent a parastomal hernia shows there are serious but well-recognised complications. The evidence on efficacy is limited in quantity and quality. Therefore, this procedure should not be used unless  special arrangements   are in place for clinical governance, consent, and audit or research.

    synthetic or biological mesh used, mesh-associated complications and long-term outcomes (at least 3 years). In participating centres,...

    Research recommendation
    Published
    15 November 2019

  49. Organisation of care:- What is the clinical and cost effectiveness of alternative approaches to organising primary care compared with usual care for people with multimorbidity?

    multiple providers or services involved in their care, people with both long-term physical and mental health problems, people with...

    Research recommendation
    Published
    18 October 2016

  50. FreeStyle Libre for glucose monitoring (MIB110)

    NICE has developed a medtech innovation briefing (MIB) on FreeStyle Libre for glucose monitoring .

    Medtech innovation briefing
    Last updated
    29 September 2017