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Showing 1751 to 1800 of 2468 results for term

  1. What is the relative effectiveness and cost effectiveness of the different components of multi-component, community-based oral health improvement programmes?

    It should include studies with sufficient follow-up to consider the long term impact of poor oral health. Research should include...

    Research recommendation
    Published
    9 June 2015

  2. Are comprehensive early interventions that combine multiple elements and are delivered by parents and teachers (for example, the Learning Experiences – an Alternative Program for Preschoolers and their Parents [LEAP] model) effective in managing the core features of autism and coexisting difficulties (such as adaptive behaviour and developmental skills) in pre‑school children?

    intensity required to ensure effectiveness of the programme, as well as longer-term outcomes. Source guidance details Comes from...

    Research recommendation
    Published
    10 August 2021

  3. Preventing behaviour that challenges from developing in children aged under 5 years with a learning disability:- Can positive behaviour support provided for children aged under 5 years with a learning disability reduce the risk of developing behaviour that challenges?

    the interventions in a large scale randomised controlled trial with long-term follow-up- evaluating the implementation of the...

    Research recommendation
    Published
    5 October 2015

  4. Pharmacological treatment: In people in hospital who have delirium, which is the most effective medication (atypical antipsychotics, typical antipsychotics or benzodiazepines) compared with placebo or each other for treating delirium?

    guidance Delirium: prevention, diagnosis and management in hospital and long-term care Number CG103 Date issued July 2010 Other details

    Research recommendation
    Published
    3 February 2023

  5. What community-based interventions are effective and cost effective at improving the uptake of, and reducing inequalities in the use of, dental services by groups of adults and children at high risk of poor oral health?

    It should include studies with sufficient follow-up to consider the long term impact of poor oral health. Research should include...

    Research recommendation
    Published
    9 June 2015

  6. Parent training programmes for children aged 12 years and over with a conduct disorder:- What is the effectiveness of parent training programmes for conduct disorders in children and young people aged 12 years and over?

    using a randomised controlled trial (RCT) design reporting short- and medium-term outcomes, including cost effectiveness, over at least...

    Research recommendation
    Published
    9 June 2015

  7. Maintenance treatment:- In the maintenance treatment of bipolar disorder, what is the relative effect on quality of life of lithium, an antipsychotic (haloperidol, olanzapine, quetiapine or risperidone), or a combination of lithium and an antipsychotic?

    antipsychotic medication are known to reduce the risk of relapse when used long-term in people with bipolar disorder. Relapses do still...

    Research recommendation
    Published
    9 June 2015

  8. Fever in under 5s (QS64)

    This quality standard covers the assessment and early management of fever with no obvious cause in babies and children (from birth to 5 years). It describes high-quality care in priority areas for improvement.

    Quality standard
    Last updated
    27 July 2022
    View quality statements

    Sections for QS64

  9. Pancreatic cancer (QS177)

    This quality standard covers diagnosis of pancreatic cancer and management of pancreatic ductal adenocarcinoma in adults aged over 18. This quality standard describes high-quality care in priority areas for improvement. It does not cover national initiatives, such as cancer screening or audit.

    Quality standard
    Published
    20 December 2018
    View quality statements

    Sections for QS177

  10. Sacral nerve stimulation for idiopathic chronic non-obstructive urinary retention (HTG391)

    Evidence-based recommendations on sacral nerve stimulation for idiopathic chronic non-obstructive urinary retention. This involves implanting a stimulator device into the upper buttock to restore the ability to empty the bladder voluntarily.

    HealthTech guidance
    Published
    25 November 2015
    View recommendations

    Sections for HTG391

  11. Further research on laparoscopic mesh pectopexy for apical prolapse of the uterus or vagina should include details of patient selection and long-term outcomes.

    the uterus or vagina should include details of patient selection and long-term outcomes. Any explanatory notes(if applicable) Current...

    Research recommendation
    Published
    14 November 2018

  12. Cemiplimab for treating advanced cutaneous squamous cell carcinoma (TA802)

    Evidence-based recommendations on cemiplimab (Libtayo) for metastatic or locally advanced cutaneous squamous cell carcinoma in adults.

    Technology appraisal guidance
    Published
    29 June 2022
    View recommendations

    Sections for TA802

  13. Reablement:- How effective and cost effective are repeated periods of reablement, and reablement that lasts longer than 6 weeks?

    weeks, or both.Comparative studies are also needed to understand the long-term impact of duration on costs and patient outcomes, by...

    Research recommendation
    Published
    15 October 2018

  14. Angioplasty versus bypass surgery for treating people with critical limb ischaemia caused by disease of the infra-geniculate arteries:- What is the clinical and cost effectiveness of a 'bypass surgery first' strategy compared with an 'angioplasty first' strategy for treating people with critical limb ischaemia caused by disease of the infra-geniculate (below the knee) arteries?

    surgery may be associated with significant morbidity, the resulting long-term amputation-free survival rates are generally good. In...

    Research recommendation
    Published
    9 June 2015

  15. Compression after interventional treatment:- What is the clinical and cost effectiveness of compression bandaging or hosiery after interventional treatment for varicose veins compared with no compression? If there is benefit, how long should compression bandaging or hosiery be worn for?

    improve quality of life for people with varicose veins and reduce the longer-term need for retreatment. Source guidance details Comes...

    Research recommendation
    Published
    9 June 2015

  16. Compulsion, control and restraint:- For people using adult mental health services, how is compulsory treatment and 'control and restraint' used in different settings and what is the impact on the service user?

    compulsory treatment and restraint on service user experience, and its longer-term impact. Source guidance details Comes from guidance...

    Research recommendation
    Published
    9 June 2015

  17. Specific versus generic CBT for children and young people with social anxiety disorder:- What is the clinical and cost effectiveness of specific CBT for children and young people with social anxiety disorder compared with generic anxiety-focused CBT?

    question should be answered using an RCT design, reporting short- and medium-term outcomes (including cost-effectiveness) with a...

    Research recommendation
    Published
    9 June 2015

  18. Pharmacological treatments for headache prophylaxis to aid withdrawal treatment in medication overuse headache:- Does a course of steroid treatment or pharmacological treatments used for headache prophylaxis help people with medication overuse headaches withdraw from medication?

    overuse headache find it difficult to withdraw abruptly because in the short term their headaches can become much worse. The use of...

    Research recommendation
    Published
    9 June 2015

  19. Erdafitinib for treating unresectable or metastatic urothelial cancer with FGFR3 alterations after a PD-1 or PD-L1 inhibitor (TA1062)

    Evidence-based recommendations on erdafitinib (Balversa) for treating unresectable or metastatic urothelial cancer with FGFR3 alterations after a PD-1 or PD-L1 inhibitor in adults.

    Technology appraisal guidance
    Published
    12 May 2025

    Sections for TA1062

  20. Content and nature of effective de-escalation:- What is the content and nature of effective de-escalatory actions, interactions and activities used by mental health nurses, including the most effective and efficient means of training nurses to usethem in a timely and appropriate way?

    guidance details Comes from guidance Violence and aggression: short-term management in mental health, health and community settings...

    Research recommendation
    Published
    5 October 2015

  21. Reducing car ownership:- Does reducing car use or ownership change physical activity levels? Are effects maintained over time?

    to understand how it interacts with physical activity and, in the longer term, health status. An objective measure of physical activity...

    Research recommendation
    Published
    15 November 2018

  22. Long duration or very frequent manual restraint:- In what circumstances and how often are long-duration or repeated manual restraint used, and what alternatives are there that are safer and more effective?

    guidance details Comes from guidance Violence and aggression: short-term management in mental health, health and community settings...

    Research recommendation
    Published
    1 October 2015

  23. Narcolepsy with or without cataplexy in adults: pitolisant (ES8)

    Summary on the evidence on pitolisant for treating narcolepsy with or without cataplexy to inform local NHS planning and decision-making

    Evidence summary
    Published
    14 March 2017

  24. The evidence on the safety of transurethral laser ablation for recurrent non-muscle-invasive bladder cancer shows that there are no major safety concerns. However, current evidence on its efficacy is limited in quality and quantity. Therefore, this procedure should only be used with  special arrangements   for clinical governance, consent, and audit or research.

    investigate patient selection, types of laser used, tumour recurrence and long-term follow up. Source guidance details Comes from...

    Research recommendation
    Published
    15 November 2019

  25. Acne vulgaris: management (NG198)

    This guideline covers management of acne vulgaris in primary and specialist care. It includes advice on topical and oral treatments (including antibiotics and retinoids), treatment using physical modalities, and the impact of acne vulgaris on mental health and wellbeing.

    NICE guideline
    Last updated
    7 December 2023
    View recommendations

    Sections for NG198

  26. Further research on aortic valve reconstruction with processed bovine pericardium should address patient selection and report long-term outcomes, particularly the durability of the valve.

    processed bovine pericardium should address patient selection and report long-term outcomes, particularly the durability of the valve....

    Research recommendation
    Published
    13 November 2018

  27. Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis (TA199)

    Evidence-based recommendations on etanercept (Enbrel), infliximab (Remicade) and adalimumab (Humira) for treating active and progressive psoriatic arthritis in adults.

    Technology appraisal guidance
    Published
    25 August 2010
    View recommendations

    Sections for TA199

  28. Use of hearing aids and incidence of dementia:- In adults with hearing loss, does the use of hearing aids reduce the incidence of dementia?

    the incidence of dementia is increasing. Dementia has considerable long-term costs for people with dementia, their families and the...

    Research recommendation
    Published
    10 December 2018

  29. What overall osmolality (or concentration of calcium and glucose/dextrose) in parenteral nutrition can determine whether to administer centrally or peripherally?

    was supported by the evidence) when use of a peripheral line will be short term, and should be used when parenteral nutrition would...

    Research recommendation
    Published
    17 March 2020

  30. Artificial intelligence (AI) technologies to aid contouring for radiotherapy treatment planning: early value assessment (HTG695)

    Early value assessment (EVA) guidance on artificial intelligence (AI) technologies to aid contouring for radiotherapy treatment planning in people having external beam radiotherapy.

    HealthTech guidance
    Published
    27 September 2023
    View recommendations

    Sections for HTG695

  31. PredictSURE IBD and IBDX to guide treatment of Crohn's disease (HTG610)

    Evidence-based recommendations on PredictSURE IBD and IBDX for guiding treatment of Crohn’s disease.

    HealthTech guidance
    Published
    23 February 2022
    View recommendations

    Sections for HTG610

  32. Gallstone disease: diagnosis and management (CG188)

    This guideline covers diagnosing and managing gallstone disease in adults. It aims to reduce variation in care by promoting the most effective treatments, and to improve the advice given to people with gallstone disease before and after treatment.

    Clinical guideline
    Published
    29 October 2014
    View recommendations

    Sections for CG188

  33. Erythropoiesis‑stimulating agents (epoetin and darbepoetin) for treating anaemia in people with cancer having chemotherapy (TA323)

    Evidence-based recommendations on erythropoiesis-stimulating agents (epoetin alfa [Eprex], epoetin beta [NeoRecormon], epoetin theta, epoeitin zeta [Retacrit] and darbepoetin alfa [Aranesp]) for treating anaemia in adults with cancer having chemotherapy.

    Technology appraisal guidance
    Published
    26 November 2014
    View recommendations

    Sections for TA323

  34. Developmental follow-up of children and young people born preterm (QS169)

    This quality standard covers the developmental follow-up of babies, children and young people under 18 years who were born preterm (before 37+0 weeks of pregnancy). It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    18 May 2018
    View quality statements

    Sections for QS169

  35. Anaphylaxis (QS119)

    This quality standard covers care after emergency treatment for suspected anaphylaxis, including assessment and referral to specialist allergy services. It describes high-quality care in priority areas for improvement.

    Quality standard
    Last updated
    31 July 2024
    View quality statements

    Sections for QS119

  36. Transient loss of consciousness ('blackouts') in over 16s (QS71)

    This quality standard covers assessing, diagnosing and referring people (aged 16 and over) who have had a transient loss of consciousness (often called a blackout). It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    2 October 2014
    View quality statements

    Sections for QS71

  37. Diabetes in pregnancy (QS109)

    This quality standard covers managing diabetes and its complications in women who are planning a pregnancy or are already pregnant. It includes care for women with pre-existing diabetes before and during pregnancy, and diagnosis and management of gestational diabetes. It describes high-quality care in priority areas for improvement.

    Quality standard
    Last updated
    10 January 2023
    View quality statements

    Sections for QS109

  38. Repetitive transcranial magnetic stimulation for depression (HTG396)

    Evidence-based recommendations on repetitive transcranial magnetic stimulation for depression. This involves placing an electromagnetic coil against the scalp, which creates electric currents in certain parts of the brain.

    HealthTech guidance
    Published
    16 December 2015
    View recommendations

    Sections for HTG396

  39. The evidence on the safety of reinforcement of a permanent stoma with a synthetic or biological mesh to prevent a parastomal hernia shows there are serious but well-recognised complications. The evidence on efficacy is limited in quantity and quality. Therefore, this procedure should not be used unless  special arrangements   are in place for clinical governance, consent, and audit or research.

    synthetic or biological mesh used, mesh-associated complications and long-term outcomes (at least 3 years). In participating centres,...

    Research recommendation
    Published
    15 November 2019

  40. Organisation of care:- What is the clinical and cost effectiveness of alternative approaches to organising primary care compared with usual care for people with multimorbidity?

    multiple providers or services involved in their care, people with both long-term physical and mental health problems, people with...

    Research recommendation
    Published
    18 October 2016

  41. GaitSmart rehabilitation exercise programme for gait and mobility issues (HTG716)

    Evidence-based recommendations on GaitSmart rehabilitation exercise programme for gait and mobility issues in adults.

    HealthTech guidance
    Published
    3 April 2024
    View recommendations

    Sections for HTG716

  42. Public board meeting agenda and papers: May 2024

    Agenda and papers of the NICE public board meeting on 15 May 2024

  43. Pemetrexed for the treatment of malignant pleural mesothelioma (TA135)

    Evidence-based recommendations on pemetrexed for treating malignant pleural mesothelioma in adults.

    Technology appraisal guidance
    Published
    23 January 2008
    View recommendations

    Sections for TA135

  44. OSNA for colon cancer staging (MIB77)

    NICE has developed a medtech innovation briefing (MIB) on OSNA for colon cancer staging

    Medtech innovation briefing
    Published
    24 August 2016

  45. NICE indicator process guide (PMG44)

    This guide describes the process NICE uses to develop indicators from NICE quality standards, NICE guidance or other sources of high-quality evidence

  46. The effect of injectable contraceptives on bone mineral density in women who have used DMPA for longer than 2 years is uncertain. Adequately powered surveys or cross‑sectional studies are needed to examine the recovery of bone mineral density after discontinuation of DMPA after long‑term and very long‑term use. Studies are also needed to examine the risk of bone fractures in older women.

    of bone mineral density after discontinuation of DMPA after long‑term and very long‑term use. Studies are also needed to...

    Research recommendation
    Published
    25 October 2019

  47. Behaviour change: digital and mobile health interventions (NG183)

    This guideline covers interventions that use a digital or mobile platform to help people eat more healthily, become more active, stop smoking, reduce their alcohol intake or practise safer sex. The interventions include those delivered by text message, apps, wearable devices or the internet. The guideline only includes those that are delivered by the technology itself and not by healthcare professionals using technology to deliver interventions.

    NICE guideline
    Published
    7 October 2020
    View recommendations

    Sections for NG183

  48. Evidence on the safety and efficacy of prostatic urethral temporary implant insertion for lower urinary tract symptoms caused by benign prostatic hyperplasia is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    report details of patient selection, including size of prostate, and longer-term outcomes, including the need for reintervention. Source...

    Research recommendation
    Published
    30 September 2022

  49. Evidence on the efficacy and safety of neurostimulation of lumbar muscles for refractory non-specific chronic low back pain is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    appropriate duration. It should report details of patient selection and long-term outcomes. Source guidance details Comes from guidance...

    Research recommendation
    Published
    30 September 2022

  50. Effectiveness and cost effectiveness of drug misuse prevention interventions for groups vulnerable to drug misuse:- What is the effectiveness and cost effectiveness of drug misuse prevention interventions for groups vulnerable to drug misuse in the UK?

    Primary outcomes of interest include a direct measure of drug use. Longer term outcomes (longer than 1 year) from longitudinal studies...

    Research recommendation
    Published
    4 May 2017