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  1. trublood-prostate for triaging and diagnosing people with prostate cancer symptoms (MIB268)

    NICE has developed a medtech innovation briefing (MIB) on trublood-prostate for triaging and diagnosing people with prostate cancer symptoms .

    Medtech innovation briefing
    Published
    13 July 2021

  2. Adults' uptake of and engagement with interventions for social anxiety disorder:- What methods are effective in improving uptake of and engagement with interventions for adults with social anxiety disorder?

    a randomised controlled trial (RCT) design that reports short- and medium-term outcomes (including cost effectiveness) of at least 18...

    Research recommendation
    Published
    9 June 2015

  3. Education programme: Does a staff education programme (compared with an educational leaflet or usual care) reduce the incidence of delirium and improve the recognition and recording of delirium in people in hospital?

    guidance Delirium: prevention, diagnosis and management in hospital and long-term care Number CG103 Date issued July 2010 Other details

    Research recommendation
    Published
    3 February 2023

  4. Is a medication review more clinically and cost effective at reducing the suboptimal use of medicines and medicines-related patient safety incidents, compared with usual care or other interventions, in children?

    the benefit from them having medication reviews. There may be some longer-term gains with this approach, as from a young age the child...

    Research recommendation
    Published
    9 June 2015

  5. Prophylactic cervical cerclage compared with prophylactic vaginal progesterone for preventing preterm birth:- What is the clinical effectiveness of prophylactic cervical cerclage alone compared with prophylactic vaginal progesterone alone and with both strategies together for preventing preterm birth in women with a short cervix and a history of spontaneous preterm birth?

    birth causes significant neonatal morbidity and mortality, as well as long-term disability. Therefore strategies for preventing preterm...

    Research recommendation
    Published
    11 December 2015

  6. Fever in under 5s (QS64)

    This quality standard covers the assessment and early management of fever with no obvious cause in babies and children (from birth to 5 years). It describes high-quality care in priority areas for improvement.

    Quality standard
    Last updated
    27 July 2022
    View quality statements

    Sections for QS64

  7. Pancreatic cancer (QS177)

    This quality standard covers diagnosis of pancreatic cancer and management of pancreatic ductal adenocarcinoma in adults aged over 18. This quality standard describes high-quality care in priority areas for improvement. It does not cover national initiatives, such as cancer screening or audit.

    Quality standard
    Published
    20 December 2018
    View quality statements

    Sections for QS177

  8. Cemiplimab for treating advanced cutaneous squamous cell carcinoma (TA802)

    Evidence-based recommendations on cemiplimab (Libtayo) for metastatic or locally advanced cutaneous squamous cell carcinoma in adults.

    Technology appraisal guidance
    Published
    29 June 2022
    View recommendations

    Sections for TA802

  9. Erdafitinib for treating unresectable or metastatic urothelial cancer with FGFR3 alterations after a PD-1 or PD-L1 inhibitor (TA1062)

    Evidence-based recommendations on erdafitinib (Balversa) for treating unresectable or metastatic urothelial cancer with FGFR3 alterations after a PD-1 or PD-L1 inhibitor in adults.

    Technology appraisal guidance
    Published
    12 May 2025

    Sections for TA1062

  10. Antibiotic resistance in treating spontaneous bacterial peritonitis:- How frequently does antibiotic resistance occur, and how significant are antibiotic treatment-related complications when antibiotics are used for the primary prevention of spontaneous bacterial peritonitis in people at high risk of having, or developing, cirrhosis?

    prevalence and consequences of antibacterial resistance that may occur during long-term oral antibiotic therapy when used to prevent...

    Research recommendation
    Published
    11 January 2024

  11. Early revascularisation strategy for people with angina and multivessel disease:- In people with stable angina and multivessel disease (including left main stem disease) whose symptoms are controlled with optimal drug treatment, would an initial treatment strategy of revascularisation be clinically and cost effective compared with continued drug treatment?

    determine whether early investigation and revascularisation can improve longer term survival. People with stable angina may be...

    Research recommendation
    Published
    9 June 2015

  12. FRAX and QFracture in adults living in residential care:- What is the utility of FRAX and QFracture in detecting risk of fragility fracture in adults living in residential care?

    to the 9th decade and use 10-year fracture risk, may underestimate short-term risk in care home residents, who have a mean age of...

    Research recommendation
    Published
    9 June 2015

  13. Current evidence on the safety and efficacy of radially emitting laser fibre treatment of an anal fistula is limited in quantity and quality. Therefore, although there are no major safety concerns, this procedure should only be used with special arrangements  for clinical governance, consent, and audit or research.

    selection, including fistula size, recurrence rates in the medium and long term, and quality-of-life outcomes. Source guidance details...

    Research recommendation
    Published
    15 November 2019

  14. How safe are drugs used to treat bipolar disorder in pregnancy and the postnatal period?

    not well described. The question should be addressed by establishing a long-term register of women with bipolar disorder to provide data...

    Research recommendation
    Published
    13 July 2017

  15. In adults having elective knee replacement, what is the clinical and cost effectiveness of total knee replacement with patella resurfacing compared with selective resurfacing?

    more than offset by reduced numbers of hospital readmissions in the long term. Source guidance details Comes from guidance Joint

    Research recommendation
    Published
    10 August 2020

  16. Individual versus group CBT for children and young people with social anxiety disorder:- What is the clinical and cost effectiveness of individual and group CBT for children and young people with social anxiety disorder?

    young people with social anxiety disorder. It should report short- and medium-term outcomes (including cost effectiveness) with a...

    Research recommendation
    Published
    9 June 2015

  17. Lifestyle interventions (diet and exercise):- Are specialist lifestyle interventions (diet and exercise) effective, compared with no specialist lifestyle interventions, for women with endometriosis?

    notes(if applicable) Why this is important:- Endometriosis is a long-term condition that can cause acute and chronic pain, and fatigue....

    Research recommendation
    Published
    15 October 2018

  18. Tools for case identification for cognitive impairment in criminal justice system populations:- What are the reliable and valid tools to identify cognitive impairment among people in contact with the criminal justice system (including people who have experienced physical trauma, neurodevelopmental disorders or other acquired cognitive impairment)?

    effective management strategies, could be important in limiting the long-term impact of acquired cognitive impairment. However, there is...

    Research recommendation
    Published
    16 May 2017

  19. What community-based interventions are effective and cost effective in improving dietary habits affecting the oral health of children and adults, and in particular those at high risk of poor oral health?

    It should include studies with sufficient follow-up to consider the long term impact of poor oral health. Research should include...

    Research recommendation
    Published
    9 June 2015

  20. What community-based interventions are effective and cost effective in improving oral health and reducing oral health inequalities among groups of adults at high risk of poor oral health?

    It should include studies with sufficient follow-up to consider the long term impact of poor oral health. Research should include...

    Research recommendation
    Published
    9 June 2015

  21. What community-based interventions are effective and cost effective in improving oral health and reducing oral health inequalities among groups of children at high risk of poor oral health?

    It should include studies with sufficient follow-up to consider the long term impact of poor oral health. Research should include...

    Research recommendation
    Published
    9 June 2015

  22. Mental health interventions to support discharge from general inpatient hospital settings:- What interventions are cost effective in supporting people with mental health difficulties on discharge from general hospital inpatient settings?

    delirium because early identification of difficulties might lead to long-term savings for the public sector and society.Research is...

    Research recommendation
    Published
    29 January 2016

  23. What is the relative effectiveness and cost effectiveness of the different components of multi-component, community-based oral health improvement programmes?

    It should include studies with sufficient follow-up to consider the long term impact of poor oral health. Research should include...

    Research recommendation
    Published
    9 June 2015

  24. Further research on laparoscopic mesh pectopexy for apical prolapse of the uterus or vagina should include details of patient selection and long-term outcomes.

    the uterus or vagina should include details of patient selection and long-term outcomes. Any explanatory notes(if applicable) Current...

    Research recommendation
    Published
    14 November 2018

  25. Are comprehensive early interventions that combine multiple elements and are delivered by parents and teachers (for example, the Learning Experiences – an Alternative Program for Preschoolers and their Parents [LEAP] model) effective in managing the core features of autism and coexisting difficulties (such as adaptive behaviour and developmental skills) in pre‑school children?

    intensity required to ensure effectiveness of the programme, as well as longer-term outcomes. Source guidance details Comes from...

    Research recommendation
    Published
    10 August 2021

  26. Preventing behaviour that challenges from developing in children aged under 5 years with a learning disability:- Can positive behaviour support provided for children aged under 5 years with a learning disability reduce the risk of developing behaviour that challenges?

    the interventions in a large scale randomised controlled trial with long-term follow-up- evaluating the implementation of the...

    Research recommendation
    Published
    5 October 2015

  27. Pharmacological treatment: In people in hospital who have delirium, which is the most effective medication (atypical antipsychotics, typical antipsychotics or benzodiazepines) compared with placebo or each other for treating delirium?

    guidance Delirium: prevention, diagnosis and management in hospital and long-term care Number CG103 Date issued July 2010 Other details

    Research recommendation
    Published
    3 February 2023

  28. What community-based interventions are effective and cost effective at improving the uptake of, and reducing inequalities in the use of, dental services by groups of adults and children at high risk of poor oral health?

    It should include studies with sufficient follow-up to consider the long term impact of poor oral health. Research should include...

    Research recommendation
    Published
    9 June 2015

  29. Parent training programmes for children aged 12 years and over with a conduct disorder:- What is the effectiveness of parent training programmes for conduct disorders in children and young people aged 12 years and over?

    using a randomised controlled trial (RCT) design reporting short- and medium-term outcomes, including cost effectiveness, over at least...

    Research recommendation
    Published
    9 June 2015

  30. Maintenance treatment:- In the maintenance treatment of bipolar disorder, what is the relative effect on quality of life of lithium, an antipsychotic (haloperidol, olanzapine, quetiapine or risperidone), or a combination of lithium and an antipsychotic?

    antipsychotic medication are known to reduce the risk of relapse when used long-term in people with bipolar disorder. Relapses do still...

    Research recommendation
    Published
    9 June 2015

  31. Acne vulgaris: management (NG198)

    This guideline covers management of acne vulgaris in primary and specialist care. It includes advice on topical and oral treatments (including antibiotics and retinoids), treatment using physical modalities, and the impact of acne vulgaris on mental health and wellbeing.

    NICE guideline
    Last updated
    30 April 2026
    View recommendations

    Sections for NG198

  32. Sacral nerve stimulation for idiopathic chronic non-obstructive urinary retention (HTG391)

    Evidence-based recommendations on sacral nerve stimulation for idiopathic chronic non-obstructive urinary retention. This involves implanting a stimulator device into the upper buttock to restore the ability to empty the bladder voluntarily.

    HealthTech guidance
    Published
    25 November 2015
    View recommendations

    Sections for HTG391

  33. Reablement:- How effective and cost effective are repeated periods of reablement, and reablement that lasts longer than 6 weeks?

    weeks, or both.Comparative studies are also needed to understand the long-term impact of duration on costs and patient outcomes, by...

    Research recommendation
    Published
    15 October 2018

  34. Angioplasty versus bypass surgery for treating people with critical limb ischaemia caused by disease of the infra-geniculate arteries:- What is the clinical and cost effectiveness of a 'bypass surgery first' strategy compared with an 'angioplasty first' strategy for treating people with critical limb ischaemia caused by disease of the infra-geniculate (below the knee) arteries?

    surgery may be associated with significant morbidity, the resulting long-term amputation-free survival rates are generally good. In...

    Research recommendation
    Published
    9 June 2015

  35. Compression after interventional treatment:- What is the clinical and cost effectiveness of compression bandaging or hosiery after interventional treatment for varicose veins compared with no compression? If there is benefit, how long should compression bandaging or hosiery be worn for?

    improve quality of life for people with varicose veins and reduce the longer-term need for retreatment. Source guidance details Comes...

    Research recommendation
    Published
    9 June 2015

  36. Compulsion, control and restraint:- For people using adult mental health services, how is compulsory treatment and 'control and restraint' used in different settings and what is the impact on the service user?

    compulsory treatment and restraint on service user experience, and its longer-term impact. Source guidance details Comes from guidance...

    Research recommendation
    Published
    9 June 2015

  37. Specific versus generic CBT for children and young people with social anxiety disorder:- What is the clinical and cost effectiveness of specific CBT for children and young people with social anxiety disorder compared with generic anxiety-focused CBT?

    question should be answered using an RCT design, reporting short- and medium-term outcomes (including cost-effectiveness) with a...

    Research recommendation
    Published
    9 June 2015

  38. Pharmacological treatments for headache prophylaxis to aid withdrawal treatment in medication overuse headache:- Does a course of steroid treatment or pharmacological treatments used for headache prophylaxis help people with medication overuse headaches withdraw from medication?

    overuse headache find it difficult to withdraw abruptly because in the short term their headaches can become much worse. The use of...

    Research recommendation
    Published
    9 June 2015

  39. Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis (TA199)

    Evidence-based recommendations on etanercept (Enbrel), infliximab (Remicade) and adalimumab (Humira) for treating active and progressive psoriatic arthritis in adults.

    Technology appraisal guidance
    Published
    25 August 2010
    View recommendations

    Sections for TA199

  40. Content and nature of effective de-escalation:- What is the content and nature of effective de-escalatory actions, interactions and activities used by mental health nurses, including the most effective and efficient means of training nurses to usethem in a timely and appropriate way?

    guidance details Comes from guidance Violence and aggression: short-term management in mental health, health and community settings...

    Research recommendation
    Published
    5 October 2015

  41. Reducing car ownership:- Does reducing car use or ownership change physical activity levels? Are effects maintained over time?

    to understand how it interacts with physical activity and, in the longer term, health status. An objective measure of physical activity...

    Research recommendation
    Published
    15 November 2018

  42. Long duration or very frequent manual restraint:- In what circumstances and how often are long-duration or repeated manual restraint used, and what alternatives are there that are safer and more effective?

    guidance details Comes from guidance Violence and aggression: short-term management in mental health, health and community settings...

    Research recommendation
    Published
    1 October 2015

  43. The evidence on the safety of transurethral laser ablation for recurrent non-muscle-invasive bladder cancer shows that there are no major safety concerns. However, current evidence on its efficacy is limited in quality and quantity. Therefore, this procedure should only be used with  special arrangements   for clinical governance, consent, and audit or research.

    investigate patient selection, types of laser used, tumour recurrence and long-term follow up. Source guidance details Comes from...

    Research recommendation
    Published
    15 November 2019

  44. Narcolepsy with or without cataplexy in adults: pitolisant (ES8)

    Summary on the evidence on pitolisant for treating narcolepsy with or without cataplexy to inform local NHS planning and decision-making

    Evidence summary
    Published
    14 March 2017

  45. Artificial intelligence (AI) technologies to aid contouring for radiotherapy treatment planning: early value assessment (HTG695)

    Early value assessment (EVA) guidance on artificial intelligence (AI) technologies to aid contouring for radiotherapy treatment planning in people having external beam radiotherapy.

    HealthTech guidance
    Published
    27 September 2023
    View recommendations

    Sections for HTG695

  46. Erythropoiesis‑stimulating agents (epoetin and darbepoetin) for treating anaemia in people with cancer having chemotherapy (TA323)

    Evidence-based recommendations on erythropoiesis-stimulating agents (epoetin alfa [Eprex], epoetin beta [NeoRecormon], epoetin theta, epoeitin zeta [Retacrit] and darbepoetin alfa [Aranesp]) for treating anaemia in adults with cancer having chemotherapy.

    Technology appraisal guidance
    Published
    26 November 2014
    View recommendations

    Sections for TA323

  47. PredictSURE IBD and IBDX to guide treatment of Crohn's disease (HTG610)

    Evidence-based recommendations on PredictSURE IBD and IBDX for guiding treatment of Crohn’s disease.

    HealthTech guidance
    Published
    23 February 2022
    View recommendations

    Sections for HTG610

  48. Gallstone disease: diagnosis and management (CG188)

    This guideline covers diagnosing and managing gallstone disease in adults. It aims to reduce variation in care by promoting the most effective treatments, and to improve the advice given to people with gallstone disease before and after treatment.

    Clinical guideline
    Published
    29 October 2014
    View recommendations

    Sections for CG188

  49. Developmental follow-up of children and young people born preterm (QS169)

    This quality standard covers the developmental follow-up of babies, children and young people under 18 years who were born preterm (before 37+0 weeks of pregnancy). It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    18 May 2018
    View quality statements

    Sections for QS169

  50. Anaphylaxis (QS119)

    This quality standard covers care after emergency treatment for suspected anaphylaxis, including assessment and referral to specialist allergy services. It describes high-quality care in priority areas for improvement.

    Quality standard
    Last updated
    31 July 2024
    View quality statements

    Sections for QS119