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Showing 2851 to 2900 of 3765 results for treatment

  1. Second-generation endometrial ablation for HMB associated with myometrial pathology:- Are outcomes after second-generation endometrial ablation for women with HMB associated with myometrial pathology (adenomyosis and/or uterine fibroids) equivalent to those for women without myometrial pathology?

    common uterine pathologies in women presenting with HMB. Pharmacological treatments appear to be less effective in the presence of these...

    Research recommendation
    Published
    14 November 2018

  2. Care and support of people growing older with learning disabilities (NG96)

    This guideline covers care and support for adults with learning disabilities as they grow older. It covers identifying changing needs, planning for the future, and delivering services including health, social care and housing. It aims to support people to access the services they need as they get older.

    NICE guideline
    Published
    11 April 2018
    View recommendations

    Sections for NG96

  3. Lifestyle interventions (diet and exercise):- Are specialist lifestyle interventions (diet and exercise) effective, compared with no specialist lifestyle interventions, for women with endometriosis?

    the condition and ways of managing it that support surgical and medical treatment. However, no high-quality research was identified on...

    Research recommendation
    Published
    15 October 2018

  4. Pain management programmes:- Are pain management programmes a clinically and cost-effective intervention for women with endometriosis?

    Furthermore, pain management programmes have not been compared with other treatments available for endometriosis. Pain management...

    Research recommendation
    Published
    15 October 2018

  5. There is a need for additional research on the management of bleeds that occur while people are receiving apixaban, rivaroxaban or dabigatran etexilate, as there are no antidotes or established treatments to stop active bleeding for these agents.

    rivaroxaban or dabigatran etexilate, as there are no antidotes or established treatments to stop active bleeding for these agents. Any...

    Research recommendation
    Published
    9 June 2015

  6. Epoetin alfa, epoetin beta and darbepoetin alfa for cancer treatment-induced anaemia (TA142)

    This guidance has been replaced by NICE technology appraisal guidance 323.

    Technology appraisal guidance
    Published
    28 May 2008

  7. The Epidrum for aiding access to the epidural space (MIB23)

    NICE has developed a medtech innovation briefing (MIB) on the Epidrum for aiding access to the epidural space

    Medtech innovation briefing
    Published
    2 March 2015

  8. Strategies to slow the progression of age-related macular degeneration (AMD):- What is the effectiveness of antioxidant and zinc supplements on AMD disease progression for people with early AMD at high risk of progression in the context of a randomised controlled trial?

    establish the treatment effect of antioxidant supplementation (the AREDS2 formula) on AMD progression by comparing AREDS2 formula with...

    Research recommendation
    Published
    13 November 2018

  9. MR-proADM test for use with clinical deterioration scores in cases of suspected infection (MIB195)

    NICE has developed a medtech innovation briefing (MIB) on the MR-proADM test for use with clinical deterioration scores in cases of suspected infection .

    Medtech innovation briefing
    Published
    11 October 2019

  10. Maintaining the benefits of early intervention in psychosis services after discharge:- How can the benefits of early intervention in psychosis services be maintained once service users are discharged after 3 years?

    augmented (step-down) care in community mental health services versus treatment as usual to determine whether the gains of early...

    Research recommendation
    Published
    9 June 2015

  11. Clinical trials should be conducted comparing ticagrelor with prasugrel in people with acute coronary syndromes (ACS).

    Source guidance details Comes from guidance Ticagrelor for the treatment of acute coronary syndromes Number TA236 Date issued

    Research recommendation
    Published
    9 June 2015

  12. Wireless capsule endoscopy for investigation of the small bowel (IPG101)

    Evidence-based recommendations on wireless capsule endoscopy for investigation of the small bowel. This involves the person swallowing a small capsule containing a tiny camera that takes pictures as it passes through the body.

    Interventional procedures guidance
    Published
    15 December 2004
    View recommendations

    Sections for IPG101

  13. Percutaneous insertion of a cerebral protection device to prevent cerebral embolism during TAVI (IPG650)

    Evidence-based recommendations on percutaneous insertion of a cerebral protection device to prevent cerebral embolism during TAVI in adults. This involves placing a device inside an artery near the heart.

    Interventional procedures guidance
    Published
    12 June 2019
    View recommendations

    Sections for IPG650

  14. Further research into whether ticagrelor is particularly beneficial in any clinical or biological subgroups would be useful.

    Source guidance details Comes from guidance Ticagrelor for the treatment of acute coronary syndromes Number TA236 Date issued

    Research recommendation
    Published
    9 June 2015

  15. Does the use of barbed sutures for wound closure reduce the incidence of surgical site infection?

    Comes from guidance Surgical site infections: prevention and treatment Number NG125 Date issued April 2019 Other details

    Research recommendation
    Published
    26 October 2020

  16. Which closure method or technique is the most effective for reducing surgical site infections in patients undergoing emergency surgery?

    Comes from guidance Surgical site infections: prevention and treatment Number NG125 Date issued April 2019 Other details

    Research recommendation
    Published
    26 October 2020

  17. Additional maintenance therapy for asthma uncontrolled on a moderate dose of ICS plus LABA with or without LTRA:- What is the clinical and cost effectiveness of offering additional maintenance therapy to adults, young people and children with asthma that is uncontrolled on a moderate dose of ICS plus LABA with or without LTRA?

    LAMA is not cost effective compared with treatment with a placebo. In current practice, the alternative treatment options...

    Research recommendation
    Published
    18 October 2018

  18. Donor milk banks: service operation (CG93)

    This guideline covers how donor milk banks should recruit, screen and support women who donate breast milk. It also covers how milk banks should handle and process the breast milk they receive from donors. It aims to improve the safety of donor milk and operation of donor milk services.

    Clinical guideline
    Published
    24 February 2010
    View recommendations

    Sections for CG93

  19. What is the contribution to clinical effectiveness of the timing of nasal decolonisation and body wash for the prevention of surgical site infection?

    Comes from guidance Surgical site infections: prevention and treatment Number NG125 Date issued April 2019 Other details

    Research recommendation
    Published
    26 October 2020

  20. Omalizumab for the treatment of severe persistent allergic asthma in children aged 6–11 (TA201)

    This guidance has been updated and replaced by NICE technology appraisal guidance 278.

    Technology appraisal guidance
    Published
    27 October 2010

  21. What is the clinical effectiveness of preoperative nasal decolonisation using mupirocin in combination with a chlorhexidine body wash in the whole population?

    Comes from guidance Surgical site infections: prevention and treatment Number NG125 Date issued April 2019 Other details

    Research recommendation
    Published
    16 August 2019

  22. What is the effectiveness of decolonisation using alternative interventions in combination with nasal decolonisation in the prevention of surgical site infections when chlorhexidine is contraindicated?

    Comes from guidance Surgical site infections: prevention and treatment Number NG125 Date issued April 2019 Other details

    Research recommendation
    Published
    26 October 2020

  23. What is the clinical and cost effectiveness of a double application of antiseptic to the skin at the surgical site compared with a single application?

    Comes from guidance Surgical site infections: prevention and treatment Number NG125 Date issued April 2019 Other details

    Research recommendation
    Published
    26 October 2020

  24. What is the clinical and cost effectiveness of different modes of applying skin antiseptic before incision in the prevention of surgical site infection?

    Comes from guidance Surgical site infections: prevention and treatment Number NG125 Date issued April 2019 Other details

    Research recommendation
    Published
    26 October 2020

  25. Further studies on the clinical effectiveness of mifamurtide when combined with the chemotherapy typical of UK clinical practice would be useful to determine the size of the effect of mifamurtide.

    Source guidance details Comes from guidance Mifamurtide for the treatment of osteosarcoma Number TA235 Date issued October 2011

    Research recommendation
    Published
    9 June 2015

  26. Research should be carried out to compare the clinical effectiveness of bendamustine with chlorambucil at the higher dose used in the Chronic Lymphocytic Leukaemia Trial 4 (CLL4).

    details Comes from guidance Bendamustine for the first-line treatment of chronic lymphocytic leukaemia Number TA216 Date issued

    Research recommendation
    Published
    9 June 2015

  27. Antibiotics for suspected early-onset infection: What is the incidence and severity of adverse effects with antibiotics used to prevent or treat early-onset neonatal infection?

    from guidance Neonatal infection: antibiotics for prevention and treatment Number NG195 Date issued April 2021 Other details

    Research recommendation
    Published
    6 August 2021

  28. Studies exploring the effectiveness of bevacizumab in people previously treated with a taxane and its effects on health-related quality of life.

    guidance Bevacizumab in combination with capecitabine for the first-line treatment of metastatic breast cancer Number TA263 Date issued

    Research recommendation
    Published
    9 June 2015

  29. The effectiveness of pulsatile gonadotrophin-releasing hormone in women with clomifene citrate-resistant polycystic ovary syndrome is uncertain and is therefore not recommended outside a research context. [2004]

    details Comes from guidance Fertility problems: assessment and treatment Number CG156 Date issued February 2013 Other

    Research recommendation
    Published
    9 June 2015

  30. Research is needed on the impact of treating Alzheimer's disease on mortality and institutionalisation, and to assess the relationship between disease progression and carer utility (quality of life).

    guidance Donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease Number TA217 Date issued March

    Research recommendation
    Published
    9 June 2015

  31. Hormonal therapies for the adjuvant treatment of early oestrogen-receptor-positive breast cancer (TA112)

    This guideline has been updated and replaced by NICE guideline NG101.

    Technology appraisal guidance
    Published
    22 November 2006

  32. Antibiotics for suspected early-onset infection: What is the incidence in England and Wales of resistance to commonly used antibiotics among bacteria that cause early-onset neonatal infection?

    from guidance Neonatal infection: antibiotics for prevention and treatment Number NG195 Date issued April 2021 Other details

    Research recommendation
    Published
    6 August 2021

  33. Information and support: What is the clinical and cost effectiveness of information and support offered to parents and carers of babies who have received antibiotics for suspected or proven early-onset neonatal infection?

    from guidance Neonatal infection: antibiotics for prevention and treatment Number NG195 Date issued April 2021 Other details

    Research recommendation
    Published
    6 August 2021

  34. Antibiotics for suspected early-onset infection: What are the core exposures and outcomes that should be used to evaluate clinical effectiveness of antibiotics to prevent or treat early- onset neonatal infection?

    from guidance Neonatal infection: antibiotics for prevention and treatment Number NG195 Date issued April 2021 Other details

    Research recommendation
    Published
    6 August 2021

  35. Further research designed to investigate differences in health-related quality of life and the clinical effectiveness of bevacizumab in subgroups, such as those with prior taxane exposure, would be particularly useful.

    guidance Bevacizumab in combination with a taxane for the first-line treatment of metastatic breast cancer Number TA214 Date issued

    Research recommendation
    Published
    9 June 2015

  36. Further research on the clinical effectiveness of rivaroxaban compared with low molecular weight heparin (LMWH) in patients with active cancer should be conducted.

    Source guidance details Comes from guidance Rivaroxaban for the treatment of deep vein thrombosis and prevention of recurrent deep vein...

    Research recommendation
    Published
    9 June 2015

  37. Further collection of quality of life data from people who are cured and who have experience of amputation and chemotherapy are also needed. Additional data on the health effects on parents, siblings and others with life-threatening illness would also be of value.

    Source guidance details Comes from guidance Mifamurtide for the treatment of osteosarcoma Number TA235 Date issued October 2011

    Research recommendation
    Published
    9 June 2015

  38. Research is needed to generate robust and relevant data on the effects of treating people with Alzheimer's disease on both short-term and long-term outcomes, disease progression through relevant health states, and quality of life.

    guidance Donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease Number TA217 Date issued March

    Research recommendation
    Published
    9 June 2015

  39. People who are concerned about their fertility should be informed that the effectiveness of complementary therapies for fertility problems has not been properly evaluated and that further research is needed before such interventions can be recommended. [2004]

    details Comes from guidance Fertility problems: assessment and treatment Number CG156 Date issued February 2013 Other

    Research recommendation
    Published
    9 June 2015

  40. Insertion of hydrogel keratoprosthesis (IPG69)

    Evidence-based recommendations on insertion of hydrogel keratoprosthesis. This involves putting an artificial cornea into place in a pocket made in the front part of the eye.

    Interventional procedures guidance
    Published
    23 June 2004
    View recommendations

    Sections for IPG69

  41. Managed access

    Managed access allows people to access promising new treatments that would otherwise not be recommended because it is too uncertain whether the treatment is cost-effective.

  42. A trial comparing the long-term effectiveness (beyond 24 weeks) of cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate and placebo would be beneficial. It should collect utility data as well as walking distance outcomes.

    naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral...

    Research recommendation
    Published
    9 June 2015

  43. The Committee recommends that a study estimating utility values using directly observed health-related quality of life values (such as EQ 5D scores) in patients with myelodysplastic syndromes, chronic myelomonocytic leukaemia or acute myeloid leukaemia is conducted.

    Source guidance details Comes from guidance Azacitidine for the treatment of myelodysplastic syndromes, chronic myelomonocytic leukaemia...

    Research recommendation
    Published
    9 June 2015

  44. The Committee considered that rigorous data collection is needed on the life-extending benefits of lenalidomide when used in people with multiple myeloma who have received two or more prior therapies.

    guidance details Comes from guidance Lenalidomide for the treatment of multiple myeloma in people who have received at least 2 prior...

    Research recommendation
    Published
    25 October 2019

  45. Investigations for babies who may have early-onset infection: What is the clinical and cost effectiveness of laboratory investigations used individually or in combination to exclude early-onset neonatal infection in babies receiving antibiotics for suspected infection?

    from guidance Neonatal infection: antibiotics for prevention and treatment Number NG195 Date issued April 2021 Other details

    Research recommendation
    Published
    6 August 2021

  46. What is the effect of dietary interventions or dietary changes on acne?

    committee's discussion are in evidence review C: dietary interventions for the treatment of acne vulgaris. Source guidance details Comes...

    Research recommendation
    Published
    3 May 2024

  47. Diet: What is the effect of dietary interventions or dietary changes on acne?

    committee's discussion are in evidence review C: dietary interventions for the treatment of acne vulgaris. Source guidance details Comes...

    Research recommendation
    Published
    10 August 2021

  48. Evinacumab for treating homozygous familial hypercholesterolemia in children aged 6 months to 11 [TSID11806]

    Topic prioritisation

    Technology appraisal guidance
    Topic prioritisation

  49. Endovascular closure of atrial septal defect (IPG96)

    Evidence-based recommendations on endovascular closure of atrial septal defect. This involves inserting a small blocking device into the heart, which is gently inflated to close the hole.

    Interventional procedures guidance
    Published
    27 October 2004
    View recommendations

    Sections for IPG96

  50. Complex PTSD:- What is the clinical and cost effectiveness of interventions to deliver stabilisation and reintegration for people with complex PTSD?

    psychological, psychosocial and other non-pharmacological interventions for the treatment of PTSD in adults. Source guidance details...

    Research recommendation
    Published
    13 February 2019